Regulation of Ferroptotic Cancer Cell Death by GPX4 von Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.

Volltext

Target identification and mechanism of action in chemical biology and drug discovery von Schenone, Monica, Dančík, Vlado, Wagner, Bridget K, Clemons, Paul A

Volltext

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality von Jerby-Arnon, Livnat, Pfetzer, Nadja, Waldman, Yedael Y., McGarry, Lynn, James, Daniel, Shanks, Emma, Seashore-Ludlow, Brinton, Weinstock, Adam, Geiger, Tamar, Clemons, Paul A., Gottlieb, Eyal, Ruppin, Eytan

Volltext

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion von Zou, Yilong, Henry, Whitney S., Ricq, Emily L., Graham, Emily T., Phadnis, Vaishnavi V., Maretich, Pema, Paradkar, Sateja, Boehnke, Natalie, Deik, Amy A., Reinhardt, Ferenc, Eaton, John K., Ferguson, Bryan, Wang, Wenyu, Fairman, Joshua, Keys, Heather R., Dančík, Vlado, Clish, Clary B., Clemons, Paul A., Hammond, Paula T., Boyer, Laurie A., Weinberg, Robert A., Schreiber, Stuart L.

Volltext

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis von Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.

Volltext

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles von Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

Volltext

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 von Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit

Volltext

Predicting compound activity from phenotypic profiles and chemical structures von Moshkov, Nikita, Becker, Tim, Yang, Kevin, Horvath, Peter, Dancik, Vlado, Wagner, Bridget K., Clemons, Paul A., Singh, Shantanu, Carpenter, Anne E., Caicedo, Juan C.

Volltext

High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function von Burns, Sean M., Vetere, Amedeo, Walpita, Deepika, Dančík, Vlado, Khodier, Carol, Perez, Jose, Clemons, Paul A., Wagner, Bridget K., Altshuler, David

Volltext

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset von Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L

Volltext

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules von Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.

Volltext

Route to three-dimensional fragments using diversity-oriented synthesis von Hung, Alvin W, Ramek, Alex, Wang, Yikai, Kaya, Taner, Wilson, J. Anthony, Clemons, Paul A, Young, Damian W

Volltext

Multiplex cytological profiling assay to measure diverse cellular states von Gustafsdottir, Sigrun M, Ljosa, Vebjorn, Sokolnicki, Katherine L, Anthony Wilson, J, Walpita, Deepika, Kemp, Melissa M, Petri Seiler, Kathleen, Carrel, Hyman A, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Carpenter, Anne E, Shamji, Alykhan F

Volltext

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles von Clemons, Paul A., Bodycombe, Nicole E., Carrinski, Hyman A., Wilson, J. Anthony, Shamji, Alykhan F., Wagner, Bridget K., Koehler, Angela N., Schreiber, Stuart L.

Volltext

A genetic basis for the variation in the vulnerability of cancer to DNA damage von Yard, Brian D., Adams, Drew J., Chie, Eui Kyu, Tamayo, Pablo, Battaglia, Jessica S., Gopal, Priyanka, Rogacki, Kevin, Pearson, Bradley E., Phillips, James, Raymond, Daniel P., Pennell, Nathan A., Almeida, Francisco, Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan, Peacock, Craig D., Schreiber, Stuart L., Hammerman, Peter S., Abazeed, Mohamed E.

Volltext

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease von Lamb, Justin, Crawford, Emily D., Peck, David, Modell, Joshua W., Blat, Irene C., Wrobel, Matthew J., Lerner, Jim, Brunet, Jean-Philippe, Subramanian, Aravind, Ross, Kenneth N., Reich, Michael, Hieronymus, Haley, Wei, Guo, Armstrong, Scott A., Haggarty, Stephen J., Clemons, Paul A., Wei, Ru, Carr, Steven A., Lander, Eric S., Golub, Todd R.

Volltext

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling von Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljos, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.

Volltext

Comparison of Methods for Image-Based Profiling of Cellular Morphological Responses to Small-Molecule Treatment von Ljosa, Vebjorn, Caie, Peter D., ter Horst, Rob, Sokolnicki, Katherine L., Jenkins, Emma L., Daya, Sandeep, Roberts, Mark E., Jones, Thouis R., Singh, Shantanu, Genovesio, Auguste, Clemons, Paul A., Carragher, Neil O., Carpenter, Anne E.

Volltext

Mapping the landscape of genetic dependencies in chordoma von Sharifnia, Tanaz, Wawer, Mathias J., Goodale, Amy, Lee, Yenarae, Kazachkova, Mariya, Dempster, Joshua M., Muller, Sandrine, Levy, Joan, Freed, Daniel M., Sommer, Josh, Kalfon, Jérémie, Vazquez, Francisca, Hahn, William C., Root, David E., Clemons, Paul A., Schreiber, Stuart L.

Volltext

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases von Bessen, Jeffrey L., Afeyan, Lena K., Dančík, Vlado, Koblan, Luke W., Thompson, David B., Leichner, Chas, Clemons, Paul A., Liu, David R.

Volltext