Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer von Shitara, Kohei, Ajani, Jaffer A., Moehler, Markus, Garrido, Marcelo, Gallardo, Carlos, Shen, Lin, Yamaguchi, Kensei, Wyrwicz, Lucjan, Skoczylas, Tomasz, Bragagnoli, Arinilda Campos, Liu, Tianshu, Tehfe, Mustapha, Elimova, Elena, Bruges, Ricardo, Zander, Thomas, de Azevedo, Sergio, Kowalyszyn, Ruben, Pazo-Cid, Roberto, Schenker, Michael, Cleary, James M., Yanez, Patricio, Feeney, Kynan, Karamouzis, Michalis V., Poulart, Valerie, Lei, Ming, Xiao, Hong, Kondo, Kaoru, Li, Mingshun, Janjigian, Yelena Y.

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Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer von Mayer, Robert J, Van Cutsem, Eric, Falcone, Alfredo, Yoshino, Takayuki, Garcia-Carbonero, Rocio, Mizunuma, Nobuyuki, Yamazaki, Kentaro, Shimada, Yasuhiro, Tabernero, Josep, Komatsu, Yoshito, Sobrero, Alberto, Boucher, Eveline, Peeters, Marc, Tran, Ben, Lenz, Heinz-Josef, Zaniboni, Alberto, Hochster, Howard, Cleary, James M, Prenen, Hans, Benedetti, Fabio, Mizuguchi, Hirokazu, Makris, Lukas, Ito, Masanobu, Ohtsu, Atsushi

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Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study von Bekaii-Saab, Tanios S, Prof, Ou, Fang-Shu, PhD, Ahn, Daniel H, DO, Boland, Patrick M, MD, Ciombor, Kristen K, MD, Heying, Erica N, BS, Dockter, Travis J, MS, Jacobs, Nisha L, MD, Pasche, Boris C, Prof, Cleary, James M, MD, Meyers, Jeffrey P, BS, Desnoyers, Rodwige J, MD, McCune, Jeannine S, Prof, Pedersen, Katrina, MD, Barzi, Afsaneh, MD, Chiorean, E Gabriela, Prof, Sloan, Jeffrey, Prof, Lacouture, Mario E, Prof, Lenz, Heinz-Josef, Prof, Grothey, Axel, MD

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Phase I Study of Neratinib in Combination With Temsirolimus in Patients With Human Epidermal Growth Factor Receptor 2–Dependent and Other Solid Tumors von GANDHI, Leena, BAHLEDA, Rastislav, KRYGOWSKI, Mizue, YALI LIANG, TURNBULL, Kathleen W, SHAPIRO, Geoffrey I, SORIA, Jean-Charles, TOLANEY, Sara M, KWAK, Eunice L, CLEARY, James M, PANDYA, Shuchi S, HOLLEBECQUE, Antoine, ABBAS, Richat, ANANTHAKRISHNAN, Revathi, BERKENBLIT, Anna

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Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+ gastroesophage... von Singh, Harshabad, Lowder, Kristen E., Kapner, Kevin, Kelly, Ronan J., Zheng, Hui, McCleary, Nadine Jackson, Abrams, Thomas A., Chan, Jennifer A., Regan, Eileen M., Klempner, Samuel J., Hannigan, Alison M., Remland, Joshua, Brais, Lauren K., Andrews, Elizabeth, Yurgelun, Matthew, Cleary, James M., Rubinson, Douglas A., Ritterhouse, Lauren L., Maron, Garrett, Aguirre, Andrew J., Meyerhardt, Jeffrey A., Gardecki, Emma, Lennerz, Jochen K., Wolpin, Brian M., Enzinger, Peter C.

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Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer von Patterson-Fortin, Jeffrey, Jadhav, Heta, Pantelidou, Constantia, Phan, Tin, Grochala, Carter, Mehta, Anita K., Guerriero, Jennifer L., Wulf, Gerburg M., Wolpin, Brian M., Stanger, Ben Z., Aguirre, Andrew J., Cleary, James M., D’Andrea, Alan D., Shapiro, Geoffrey I.

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Update on the role of imaging in management of metastatic colorectal cancer von Tirumani, Sree Harsha, Kim, Kyung Won, Nishino, Mizuki, Howard, Stephanie A, Krajewski, Katherine M, Jagannathan, Jyothi P, Cleary, James M, Ramaiya, Nikhil H, Shinagare, Atul B

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Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors von Razak, Albiruni RA, Cleary, James M, Moreno, Victor, Boyer, Michael, Calvo Aller, Emiliano, Edenfield, William, Tie, Jeanne, Harvey, R Donald, Rutten, Annemie, Shah, Manish A, Olszanski, Anthony J, Jäger, Dirk, Lakhani, Nehal, Ryan, David P, Rasmussen, Erik, Juan, Gloria, Wong, Hansen, Soman, Neelesh, Smit, Marie-Anne Damiette, Nagorsen, Dirk, Papadopoulos, Kyriakos P

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RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer von Patterson-Fortin, Jeffrey, Jadhav, Heta, Pantelidou, Constantia, Phan, Tin, Grochala, Carter, Mehta, Anita K., Guerriero, Jennifer L., Wulf, Gerburg M., Wolpin, Brian M., Stanger, Ben Z., Aguirre, Andrew J., Cleary, James M., D’Andrea, Alan D., Shapiro, Geoffrey I.

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Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions von Singh, Harshabad, Li, Yvonne Y, Spurr, Liam F, Shinagare, Atul B, Abhyankar, Ritika, Reilly, Emma, Brais, Lauren K, Nag, Anwesha, Ducar, Matthew D, Thorner, Aaron R, Shapiro, Geoffrey I, Keller, Rachel B, Siletti, Cheta, Clark, Jeffrey W, Farago, Anna F, Lin, Jessica J, Demetri, George D, Gujrathi, Rahul, Kulke, Matthew H, MacConaill, Laura E, Ligon, Azra H, Sicinska, Ewa, Meyerson, Matthew L, Meyerhardt, Jeffrey A, Cherniack, Andrew D, Wolpin, Brian M, Ng, Kimmie, Giannakis, Marios, Hornick, Jason L, Cleary, James M

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Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma von Cleary, James M., Rouaisnel, Betty, Daina, Antoine, Raghavan, Srivatsan, Roller, Lauren A., Huffman, Brandon M., Singh, Harshabad, Wen, Patrick Y., Bardeesy, Nabeel, Zoete, Vincent, Wolpin, Brian M., Losman, Julie-Aurore

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Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma von Mouw, Kent W, Cleary, James M, Reardon, Brendan, Pike, Jonathan, Braunstein, Lior Z, Kim, Jaegil, Amin-Mansour, Ali, Miao, Diana, Damish, Alexis, Chin, Joanna, Ott, Patrick A, Fuchs, Charles S, Martin, Neil E, Getz, Gad, Carter, Scott, Mamon, Harvey J, Hornick, Jason L, Van Allen, Eliezer M, D'Andrea, Alan D

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Biomarker-Guided Development of DNA Repair Inhibitors von Cleary, James M., Aguirre, Andrew J., Shapiro, Geoffrey I., D’Andrea, Alan D.

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Sunitinib rechallenge in metastatic renal cell carcinoma patients von Zama, Ivan N., Hutson, Thomas E., Elson, Paul, Cleary, James M., Choueiri, Toni K., Heng, Daniel Y.C., Ramaiya, Nikhil, Michaelson, M. Dror, Garcia, Jorge A., Knox, Jennifer J., Escudier, Bernard, Rini, Brian I.

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First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, op... von Janjigian, Yelena Y, Shitara, Kohei, Moehler, Markus, Garrido, Marcelo, Salman, Pamela, Shen, Lin, Wyrwicz, Lucjan, Yamaguchi, Kensei, Skoczylas, Tomasz, Campos Bragagnoli, Arinilda, Liu, Tianshu, Schenker, Michael, Yanez, Patricio, Tehfe, Mustapha, Kowalyszyn, Ruben, Karamouzis, Michalis V, Bruges, Ricardo, Zander, Thomas, Pazo-Cid, Roberto, Hitre, Erika, Feeney, Kynan, Cleary, James M, Poulart, Valerie, Cullen, Dana, Lei, Ming, Xiao, Hong, Kondo, Kaoru, Li, Mingshun, Ajani, Jaffer A

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A phase I/II study of rovalpituzumab tesirine in delta-like 3—expressing advanced solid tumors von Mansfield, Aaron S., Hong, David S., Hann, Christine L., Farago, Anna F., Beltran, Himisha, Waqar, Saiama N., Hendifar, Andrew E., Anthony, Lowell B., Taylor, Matthew H., Bryce, Alan H., Tagawa, Scott T., Lewis, Karl, Niu, Jiaxin, Chung, Christine H., Cleary, James M., Rossi, Michael, Ludwig, Carrianne, Valenzuela, Ricardo, Luo, Yan, Aggarwal, Rahul

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Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer von Kelly, Ronan J, Ajani, Jaffer A, Kuzdzal, Jaroslaw, Zander, Thomas, Van Cutsem, Eric, Piessen, Guillaume, Mendez, Guillermo, Feliciano, Josephine, Motoyama, Satoru, Lièvre, Astrid, Uronis, Hope, Elimova, Elena, Grootscholten, Cecile, Geboes, Karen, Zafar, Syed, Snow, Stephanie, Ko, Andrew H, Feeney, Kynan, Schenker, Michael, Kocon, Piotr, Zhang, Jenny, Zhu, Lili, Lei, Ming, Singh, Prianka, Kondo, Kaoru, Cleary, James M, Moehler, Markus

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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

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Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study von Abou-Alfa, Ghassan K, Macarulla, Teresa, Javle, Milind M, Kelley, Robin K, Lubner, Sam J, Adeva, Jorge, Cleary, James M, Catenacci, Daniel V, Borad, Mitesh J, Bridgewater, John, Harris, William P, Murphy, Adrian G, Oh, Do-Youn, Whisenant, Jonathan, Lowery, Maeve A, Goyal, Lipika, Shroff, Rachna T, El-Khoueiry, Anthony B, Fan, Bin, Wu, Bin, Chamberlain, Christina X, Jiang, Liewen, Gliser, Camelia, Pandya, Shuchi S, Valle, Juan W, Zhu, Andrew X

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G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans von Cardot-Ruffino, Victoire, Bollenrucher, Naima, Delius, Luisa, Wang, S Jennifer, Brais, Lauren K, Remland, Joshua, Keheler, C Elizabeth, Sullivan, Keri M, Abrams, Thomas A, Biller, Leah H, Enzinger, Peter C, McCleary, Nadine J, Patel, Anuj K, Rubinson, Douglas A, Schlechter, Benjamin, Slater, Sarah, Yurgelun, Matthew B, Cleary, James M, Perez, Kimberly, Dougan, Michael, Ng, Kimmie, Wolpin, Brian M, Singh, Harshabad, Dougan, Stephanie K

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