Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens von Myers, Andrew G, Clark, Roger B

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Fluorocyclines. 2. Optimization of the C-9 Side-Chain for Antibacterial Activity and Oral Efficacy von Clark, Roger B, Hunt, Diana K, He, Minsheng, Achorn, Catherine, Chen, Chi-Li, Deng, Yonghong, Fyfe, Corey, Grossman, Trudy H, Hogan, Philip C, O’Brien, William J, Plamondon, Louis, Rönn, Magnus, Sutcliffe, Joyce A, Zhu, Zhijian, Xiao, Xiao-Yi

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Process R&D of Eravacycline: The First Fully Synthetic Fluorocycline in Clinical Development von Ronn, Magnus, Zhu, Zhijian, Hogan, Philip C, Zhang, Wu-Yan, Niu, John, Katz, Christopher E, Dunwoody, Nicholas, Gilicky, Olga, Deng, Yonghong, Hunt, Diana K, He, Minsheng, Chen, Chi-Li, Sun, Cuixiang, Clark, Roger B, Xiao, Xiao-Yi

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Novel read through agent: ZKN-0013 demonstrates efficacy in APCmin model of familial adenomatous polyposis von Graf, Martin R., Apte, Shruti, Terzo, Esteban, Padhye, Simran, Shi, Shuhao, Cox, Megan K., Clark, Roger B., Modur, Vijay, Badarinarayana, Vasudeo

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Discovery of Novel 2‑((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders von Clark, Roger B, Lamppu, Diana, Libertine, Lyn, McDonough, Amy, Kumar, Anjali, LaRosa, Greg, Rush, Roger, Elbaum, Daniel

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Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent von Xiao, Xiao-Yi, Hunt, Diana K, Zhou, Jingye, Clark, Roger B, Dunwoody, Nick, Fyfe, Corey, Grossman, Trudy H, O’Brien, William J, Plamondon, Louis, Rönn, Magnus, Sun, Cuixiang, Zhang, Wu-Yan, Sutcliffe, Joyce A

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Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs von Sun, Cuixiang, Hunt, Diana K, Clark, Roger B, Lofland, Denene, O’Brien, William J, Plamondon, Louis, Xiao, Xiao-Yi

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A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer von Terzo, Esteban, Apte, Shruti A, Padhye, Simran, Rashed, Saleh, Austin, Wesley, Caponegro, Michael, Reddy, Anupama, Shi, Shuhao, Wang, Christy, Clark, Roger B, Sidransky, David, Modur, Vijay, Badarinarayana, Vasudeo

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Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents von Sun, Cuixiang, Hunt, Diana K, Chen, Chi-Li, Deng, Yonghong, He, Minsheng, Clark, Roger B, Fyfe, Corey, Grossman, Trudy H, Sutcliffe, Joyce A, Xiao, Xiao-Yi

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8-Azatetracyclines: Synthesis and Evaluation of a Novel Class of Tetracycline Antibacterial Agents von Clark, Roger B, He, Minsheng, Fyfe, Corey, Lofland, Denene, O’Brien, William J, Plamondon, Louis, Sutcliffe, Joyce A, Xiao, Xiao-Yi

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Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens von Sun, Cuixiang, Deng, Yonghong, Hunt, Diana K, Fyfe, Corey, Chen, Chi-Li, Clark, Roger B, Grossman, Trudy H, Sutcliffe, Joyce A, Xiao, Xiao-Yi

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Synthesis and Biological Evaluation of 8‑Aminomethyltetracycline Derivatives as Novel Antibacterial Agents von Clark, Roger B, He, Minsheng, Deng, Yonghong, Sun, Cuixiang, Chen, Chi-Li, Hunt, Diana K, O’Brien, William J, Fyfe, Corey, Grossman, Trudy H, Sutcliffe, Joyce A, Achorn, Catherine, Hogan, Philip C, Katz, Christopher E, Niu, John, Zhang, Wu-Yan, Zhu, Zhijian, Ronn, Magnus, Xiao, Xiao-Yi

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Nonstabilized N-Unsubstituted Azomethine Ylides:  A Synthesis of Indolizidine 239CD von Clark, Roger B, Pearson, William H

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Novel read through agent: ZKN-0013 demonstrates efficacy in APC min model of familial adenomatous polyposis von Graf, Martin R, Apte, Shruti, Terzo, Esteban, Padhye, Simran, Shi, Shuhao, Cox, Megan K, Clark, Roger B, Modur, Vijay, Badarinarayana, Vasudeo

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An orthogonal protection strategy for the synthesis of 2-substituted piperazines von Clark, Roger B., Elbaum, Daniel

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Solid-phase synthesis of pyrrolidines via 2-azaallyl anion cycloadditions with alkenes von Pearson, William H., Clark, Roger B.

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Formation and cycloaddition of nonstabilized N-unsubstituted azomethine ylides from (2-azaallyl)stannanes and (2-azaallyl)silanes von Pearson, William H., Clark, Roger B.

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TREATMENT OF FAMILIAL ADENOMATOUS POLYOPSIS USING A 13-MEMBERED MACROLIDE von CLARK, Roger B, MODUR, Vijay, ICHIKAWA, Yoshitaka, SHI, Shuhao, BADARINARAYANA, Vasudeo

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Compounds for Treating Genetic Diseases von Jewett, Ivan T, Li, Xiben, Austin, Wesley Francis, Clark, Roger B, Wang, Wenying, Ichikawa, Yoshitaka, Shi, Shuhao

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COMPOUNDS FOR TREATING GENETIC DISEASES von CLARK, Roger B, ICHIKAWA, Yoshitaka, SHI, Shuhao, WANG, Wenying, JEWETT, Ivan T, AUSTIN, Wesley Francis, LI, Xiben

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