Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Chol... von Rosenblum, Stuart B, Huynh, Tram, Afonso, Adriano, Davis, Harry R, Yumibe, Nathan, Clader, John W, Burnett, Duane A

Volltext

HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use von Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.

Volltext

Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry von Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W, Tagat, Jayaram R, McCombie, Stuart, Baroudy, Bahige, Moore, John P, Sakmar, Thomas P, Dragic, Tatjana

Volltext

2-Azetidinones as Inhibitors of Cholesterol Absorption von Burnett, Duane A, Caplen, Mary Ann, Davis, Harry R, Burrier, Robert E, Clader, John W

Volltext

SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo von Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.

Volltext

2-Azetidinone Cholesterol Absorption Inhibitors:  Structure−Activity Relationships on the Heterocyclic Nucleus von Clader, John W, Burnett, Duane A, Caplen, Mary Ann, Domalski, Martin S, Dugar, Sundeep, Vaccaro, Wayne, Sher, Rosy, Browne, Margaret E, Zhao, Hongrong, Burrier, Robert E, Salisbury, Brian, Davis, Harry R

Volltext

Discovery of 4-[(Z)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine N-Oxide (SCH 351125):  An Orally Bioavailable Human... von Palani, Anandan, Shapiro, Sherry, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie, Endres, Michael, Baroudy, Bahige M

Volltext

Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas von McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John

Volltext

Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists:  Orally Efficacious Antiobesity Therapeutics von McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair

Volltext

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity von Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie M, Baroudy, Bahige M

Volltext

Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity von McKittrick, Brian A, Ma, Ke, Huie, Keith, Yumibe, Nathan, Davis, Harry, Clader, John W, Czarniecki, Michael, McPhail, Andrew T

Volltext

The Discovery of Ezetimibe:  A View from Outside the Receptor von Clader, John W

Volltext

Interaction of small molecule inhibitors of HIV-1 entry with CCR5 von Seibert, Christoph, Ying, Weiwen, Gavrilov, Svetlana, Tsamis, Fotini, Kuhmann, Shawn E., Palani, Anandan, Tagat, Jayaram R., Clader, John W., McCombie, Stuart W., Baroudy, Bahige M., Smith, Steven O., Dragic, Tatjana, Moore, John P., Sakmar, Thomas P.

Volltext

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity von Clader, John W, Berger, Joel G, Burrier, Robert E, Davis, Harry R, Domalski, Martin, Dugar, Sundeep, Kogan, Timothy P, Salisbury, Brian, Vaccaro, Wayne

Volltext

Synthesis and receptor affinities of some conformationally restricted analogs of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin... von Berger, Joel G, Chang, Wei K, Clader, John W, Hou, Donald, Chipkin, Richard E, McPhail, Andrew T

Volltext

Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461 von Dugar, Sundeep, Clader, John W, Chan, Tze-Ming, Davis, Harry

Volltext

Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues von Tabas, I, Beatini, N, Chen, LL, Su, WC, Puar, MS, Dugar, S, Clader, JW

Volltext

Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity von TABAS, I, LI-LING CHEN, ZIPKIN, R. E, BOYKOW, G, VITA, G, TALL, A. R, CLADER, J. W, MCPHAIL, A. T, BURNETT, D. A, BARTNER, P, DAS, P. R, PRAMANIK, B. N, PUAR, M. S, FEINMARK, S. J

Volltext

Biphenylcarboxamide derivatives as antagonists of platelet-activating factor von Tilley, Jefferson W, Clader, John W, Zawoiski, Sonja, Wirkus, Maria, LeMahieu, Ronald A, O'Donnell, Margaret, Crowley, Herman, Welton, Ann F

Volltext

Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors von Shankar, B.B., Kirkup, M.P., McCombie, S.W., Clader, J.W., Ganguly, A.K.

Volltext