Genome-Wide DNA Copy Number Analysis of Acute Lymphoblastic Leukemia Identifies New Genetic Markers Associated with Clinical Outcome von Forero-Castro, Maribel, Robledo, Cristina, Benito, Rocío, Abáigar, María, África Martín, Ana, Arefi, Maryam, Fuster, José Luis, de Las Heras, Natalia, Rodríguez, Juan N, Quintero, Jonathan, Riesco, Susana, Hermosín, Lourdes, de la Fuente, Ignacio, Recio, Isabel, Ribera, Jordi, Labrador, Jorge, Alonso, José M, Olivier, Carmen, Sierra, Magdalena, Megido, Marta, Corchete-Sánchez, Luis A, Ciudad Pizarro, Juana, García, Juan Luis, Ribera, José M, Hernández-Rivas, Jesús M

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P343: MUTATIONS IN GENES RELATED TO EPIGENETIC REGULATION, TREATMENT RESISTANCE AND IKZF1 PLUS PROFILE IDENTIFY RELAPSE PROFILES IN B‐ALL von Valle Navas Acosta, Josgrey, Gonzalez, Teresa, Serramito, Inmaculada, Miguel, Cristina, Santos, Sandra, Villaverde, Angela, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sánchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Maria Ribera, Josep, Dávila Valls, Julio, De Las Heras Rodriguez, Natalia, Luis Fuster, José, García de Coca, Alfonso, Labrador, Jorge, Antonio Queizan, Jose, Carmen Mendoza, Mª, Riesco, Susana, Benito, Rocío, Hernández Rivas, Jesus

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Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples von CRUZ, Ignacio, CIUDAD, Juana, CRUZ, Juan Jesus, RAMOS, Manuel, GOMEZ-ALONSO, Alberto, ADANSA, Juan Carlos, RODRIGUEZ, Cesar, ORFAO, Alberto

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Tumor infiltrating immune cells in gliomas and meningiomas von Domingues, Patrícia, González-Tablas, María, Otero, Álvaro, Pascual, Daniel, Miranda, David, Ruiz, Laura, Sousa, Pablo, Ciudad, Juana, Gonçalves, Jesús María, Lopes, María Celeste, Orfao, Alberto, Tabernero, María Dolores

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The Cytogenetic Relationship between Primary and Recurrent Meningiomas Points to the Need for New Treatment Strategies in Cases at High Risk of Relapse von ESPINOSA, Ana Belén, TABERNERO, Maria Dolores, ORFAO, Alberto, MAILLO, Angel, SAYAGUES, José Maria, CIUDAD, Juana, MERINO, Marta, ALGUERO, Maria Carmen, LUBOMBO, Anne Marie, SOUSA, Pablo, SANTOS-BRIZ, Angel

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Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome–negative adult lymphoblastic leukemia von Ribera, Josep-Maria, Morgades, Mireia, Ciudad, Juana, Montesinos, Pau, Esteve, Jordi, Genescà, Eulàlia, Barba, Pere, Ribera, Jordi, García-Cadenas, Irene, Moreno, María José, Martínez-Carballeira, Daniel, Torrent, Anna, Martínez-Sánchez, Pilar, Monsalvo, Silvia, Gil, Cristina, Tormo, Mar, Artola, María Teresa, Cervera, Marta, González-Campos, José, Rodríguez, Carlos, Bermúdez, Arancha, Novo, Andrés, Soria, Beatriz, Coll, Rosa, Amigo, María-Luz, López-Martínez, Aurelio, Fernández-Martín, Rosa, Serrano, Josefina, Mercadal, Santiago, Cladera, Antònia, Giménez-Conca, Alberto, Peñarrubia, María-Jesús, Abella, Eugènia, Vall-llovera, Ferran, Hernández-Rivas, Jesús-María, Garcia-Guiñon, Antoni, Bergua, Juan-Miguel, de Rueda, Beatriz, Sánchez-Sánchez, María-José, Serrano, Alfons, Calbacho, María, Alonso, Natalia, Méndez-Sánchez, Jose-Ángel, García-Boyero, Raimundo, Olivares, Matxalen, Barrena, Susana, Zamora, Lurdes, Granada, Isabel, Lhermitte, Ludovic, Feliu, Evarist, Orfao, Alberto

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Mutually-Exclusive Pathways between IKZF1plus and RAS Mutations and TP53 double-Hit Alterations Lead Relapse in B-Other, Ph-like and Hyperdiploidy Genetic Groups in Adult B-Cell Ac... von Navas Acosta, Josgrey Del Valle Del Valle, González, Teresa, Serramito-Gómez, Inmaculada, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sanchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Valls, Julio Davila, De Las Heras, Natalia, Fuster, José, Garcia de Coca, Alfonso, Labrador, Jorge, Queizan Hernandez, Jose Antonio, Mendoza, María Carmen, Riesco, Susana, Martín, Sandra, Ribera, Josep-Maria, Benito Sanchez, Maria Rocio, Hernández-Rivas, Jesús María

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Mutually-Exclusive Pathways between IKZF1 plus and RAS Mutations and TP53 double-Hit Alterations Lead Relapse in B-Other, Ph-like and Hyperdiploidy Genetic Groups in Adult B-Cell A... von Navas Acosta, Josgrey Del Valle Del Valle, González, Teresa, Serramito-Gómez, Inmaculada, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sanchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Valls, Julio Davila, De Las Heras, Natalia, Fuster, José, Garcia de Coca, Alfonso, Labrador, Jorge, Queizan Hernandez, Jose Antonio, Mendoza, María Carmen, Riesco, Susana, Martín, Sandra, Ribera, Josep-Maria, Benito Sanchez, Maria Rocio, Hernández-Rivas, Jesús María

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IKZF1 Deletions Are Markers of Treatment Resistance in Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia Patients Treated within the Ongoing Risk-Adapted Pethema LAL19 Trial von Ribera, Jordi, Granada, Isabel, González, Teresa, Morgades, Mireia, Garcia, Olga, Sanchez, Ricardo, Such, Esperanza, Barrena, Susana, Ciudad, Juana, Soriano, Beatriz, Benito, Rocio, Avetisyan, Gayane, Lumbreras, Eva, Miguel-García, Cristina, Santos-Mínguez, Sandra, Zamora, Lurdes, Mallo, Mar, González-Gil, Celia, Genescà, Eulàlia, Lopes, Thaysa, Hernández-Rivas, Jesus Maria, Orfao, Alberto, Ribera, Josep-Maria

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Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia von Genesca, Eulalia, Morgades, Mireia, Montesinos, Pau, Barba, Pere, Gil, Cristina, Guardia, Ramon, Moreno, Maria-Jose, Martinez-Carballeira, Daniel, Garcia-Cadenas, Irene, Vives, Susana, Ribera, Jordi, Gonzalez-Campos, Jose, Gonzalez-Gil, Celia, Zamora, Lurdes, Ramirez, Jose-Luis, Diaz-Beya, Marina, Mercadal, Santiago, Artola, Maria-Teresa, Cladera, Antonia, Tormo, Mar, Bermudez, Arancha, Vall-Llovera, Ferran, Martinez, Pilar, Amigo, Maria-Luz, Monsalvo, Silvia, Novo, Andres, Cervera, Marta, Garcia-Guinon, Antoni, Junca, Jordi, Ciudad, Juana, Orfao, Alberto, Ribera, Josep-Maria

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Prognostic heterogeneity of adult B‐cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/ TCF3‐PBX1 treated with measurable residual disease‐oriented protoco... von Ribera, Jordi, Granada, Isabel, Morgades, Mireia, González, Teresa, Ciudad, Juana, Such, Esperanza, Calasanz, María José, Mercadal, Santiago, Coll, Rosa, González Campos, José, Tormo, Mar, García Cadenas, Irene, Gil, Cristina, Cervera, Marta, Barba, Pere, Costa, Dolors, Ayala, Rosa, Bermúdez, Arancha, Orfao, Alberto, Ribera, Josep Maria, Programa Español de Tratamiento en Hematología (PETHEMA) Group Spanish Society Of Hematology (SEHH)

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Prognostic heterogeneity of adult B‐cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3‐PBX1 treated with measurable residual disease‐oriented protocol... von Ribera, Jordi, Granada, Isabel, Morgades, Mireia, González, Teresa, Ciudad, Juana, Such, Esperanza, Calasanz, María‐José, Mercadal, Santiago, Coll, Rosa, González‐Campos, José, Tormo, Mar, García‐Cadenas, Irene, Gil, Cristina, Cervera, Marta, Barba, Pere, Costa, Dolors, Ayala, Rosa, Bermúdez, Arancha, Orfao, Alberto, Ribera, Josep‐Maria

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Outcome of Adults with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL) Included in Minimal Residual Disease (MRD)-Oriented Trials von Ribera, Josep-Maria, Chapchap, Eduardo Cerello, Morgades, Mireia, Genescà, Eulàlia, Gil, Cristina, García-Cadenas, Irene, Barba, Pere, González-Campos, José, Torrent, Anna, Bernal del Castillo, Teresa, Queipo De Llano, Maria Paz, Amigo, María-Luz, Tormo, Mar, Coll, Rosa, Vall-Llovera, Ferran, Ribera, Jordi, Sanchez, Maria Jose, Soria, Beatriz, Cladera, Antonia, Artola, María Teresa, Garcia-Guiñon, Antoni, Giménez Conca, Alberto, Barciela, Lourdes Amador, Ciudad, Juana, Orfao, Alberto

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Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL) von Genescà, Eulàlia, Morgades, Mireia, González-Gil, Celia, Fuster-Tormo, Francisco, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau, Barba, Pere, Gil, Cristina, Coll, Rosa, Moreno, María-José, Martínez-Carballeira, Daniel, García-Cadenas, Irene, Vives, Susana, Ribera, Jordi, González-Campos, José, Díaz-Beya, Marina, Mercadal, Santiago, Artola, María-Teresa, Cladera, Antonia, Tormo, Mar, Bermúdez, Arancha, Vall-llovera, Ferran, Martínez-Sánchez, Pilar, Amigo, María-Luz, Monsalvo, Silvia, Novo, Andrés, Cervera, Marta, García-Guiñon, Antonio, Ciudad, Juana, Cervera, José, Hernández-Rivas, Jesús-María, Granada, Isabel, Haferlach, Torsten, Orfao, Alberto, Solé, Francesc, Ribera, Josep-Maria

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ALL-268 Genetic Classification of B-Cell Precursor Adult Acute Lymphoblastic Leukemia Patients Enrolled in LAL19 Trial from the Pethema Group: Response to Treatment and Survival von Ribera, Jordi, Granada, Isabel, González, Teresa, Morgades, Mireia, Sánchez, Ricardo, Such, Esperanza, Barrena, Susana, Ciudad, Juana, Soriano, Beatriz, Benito, Rocío, Avetisyan, Gayane, Lumbreras, Eva, Miguel, Cristina, Santos, Sandra, Zamora, Lurdes, Mallo, Mar, Genescà, Eulàlia, González, Celia, Lopes, Thaysa, Hernández-Rivas, Jesús-María, Orfao, Alberto, Ribera, Josep Maria

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Poster: ALL-268 Genetic Classification of B-Cell Precursor Adult Acute Lymphoblastic Leukemia Patients Enrolled in LAL19 Trial from the Pethema Group: Response to Treatment and Sur... von Ribera, Jordi, Granada, Isabel, González, Teresa, Morgades, Mireia, Sánchez, Ricardo, Such, Esperanza, Barrena, Susana, Ciudad, Juana, Soriano, Beatriz, Benito, Rocío, Avetisyan, Gayane, Lumbreras, Eva, Miguel, Cristina, Santos, Sandra, Zamora, Lurdes, Mallo, Mar, Genescà, Eulàlia, González, Celia, Lopes, Thaysa, Hernández-Rivas, Jesús-María, Orfao, Alberto, Ribera, Josep Maria

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Molecular profiling refines minimal residual disease‐based prognostic assessment in adults with Philadelphia chromosome‐negative B‐cell precursor acute lymphoblastic leukemia von Ribera, Jordi, Zamora, Lurdes, Morgades, Mireia, Vives, Susana, Granada, Isabel, Montesinos, Pau, Gómez‐Seguí, Inés, Mercadal, Santiago, Guàrdia, Ramon, Nomdedeu, Josep, Pratcorona, Marta, Tormo, Mar, Martínez‐Lopez, Joaquín, Hernández‐Rivas, Jesús‐María, Ciudad, Juana, Orfao, Alberto, González‐Campos, José, Barba, Pere, Escoda, Lourdes, Esteve, Jordi, Genescà, Eulàlia, Solé, Francesc, Feliu, Evarist, Ribera, Josep‐Maria

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Post-Remission Treatment with Chemotherapy or Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) in Adult Patients with High-Risk (HR) Philadelphia Chromosome-Negative (... von Ribera, Josep-Maria, Morgades, Mireia, Ciudad, Juana, Montesinos, Pau, Barba, Pere, García-Cadenas, Irene, Moreno, María José, Vives, Susana, Esteve, Jordi, Gil, Cristina, Monsalvo, Silvia, Artola, María Teresa, Ribera, Jordi, Genescà, Eulàlia, Tormo, Mar, Cervera, Marta, Martínez-Carballeira, Daniel, Novo, Andrés, González-Campos, José, Soria, Beatriz, Bermúdez, Arancha, Martínez, Aurelio López, Mercadal, Santiago, Fernández-Martín, Rosa, Coll, Rosa, Serrano, Josefina, Amigo, Maria Luz, Martínez-Sánchez, Pilar, Bergua, Juan-Miguel, Serrano-Maestro, Alfons, Giménez Conca, Alberto, Barrena, Susana, Granada, Isabel, Feliu, Evarist, Orfao, Alberto

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Temperature induces variations in the retinal cell proliferation rate in a cyprinid von Velasco, Almudena, Cid, Elena, Ciudad, Juana, Orfao, Alberto, Aijon, Jose, Lara, Juan M

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Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL) von Genescà, Eulàlia, Morgades, Mireia, González Gil, Celia, Fuster Tormo, Francisco, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau, Barba, Pere, Gil, Cristina, Coll, Rosa, Moreno, María José, Martínez Carballeira, Daniel, García Cadenas, Irene, Vives, Susana, Ribera, Jordi, González Campos, José, Díaz Beyà, Marina, Mercadal, Santiago, Artola, María Teresa, Cladera, Antonia, Tormo, Mar, Bermúdez, Arancha, Vall Llovera, Ferran, Martínez Sánchez, Pilar, Amigo, María Luz, Monsalvo, Silvia, Novo, Andrés, Cervera, Marta, García Guiñon, Antonio, Ciudad, Juana, Cervera, José, Hernández Rivas, Jesús María, Granada, Isabel, Haferlach, Torsten, Orfao, Alberto, Solé, Francesc, Ribera, Josep Maria

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