Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding von Menichincheri, Maria, Albanese, Clara, Alli, Cristina, Ballinari, Dario, Bargiotti, Alberto, Caldarelli, Marina, Ciavolella, Antonella, Cirla, Alessandra, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, D’Anello, Matteo, Ermoli, Antonella, Fiorentini, Francesco, Forte, Barbara, Galvani, Arturo, Giordano, Patrizia, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Moll, Jürgen K, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Vianello, Paola, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships von Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado

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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery von Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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Combretastatins: from natural products to drug discovery von Cirla, Alessandra, Mann, John

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Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships von Polucci, Paolo, Magnaghi, Paola, Angiolini, Mauro, Asa, Daniela, Avanzi, Nilla, Badari, Alessandra, Bertrand, Jay, Casale, Elena, Cauteruccio, Silvia, Cirla, Alessandra, Cozzi, Liviana, Galvani, Arturo, Jackson, Peter K, Liu, Yichin, Magnuson, Steven, Malgesini, Beatrice, Nuvoloni, Stefano, Orrenius, Christian, Sirtori, Federico Riccardi, Riceputi, Laura, Rizzi, Simona, Trucchi, Beatrice, O’Brien, Tom, Isacchi, Antonella, Donati, Daniele, D’Alessio, Roberto

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Discovery of Stereospecific PARP‑1 Inhibitor Isoindolinone NMS-P515 von Papeo, Gianluca, Orsini, Paolo, Avanzi, Nilla R, Borghi, Daniela, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Desperati, Viviana, Donati, Daniele, Felder, Eduard R, Galvani, Arturo, Guanci, Marco, Isacchi, Antonella, Posteri, Helena, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Montagnoli, Alessia

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Abstract 4785: NMS-E668, a highly potent orally available RET inhibitor with selectivity towards VEGFR2 and demonstrated antitumor efficacy in multiple RET-driven cancer models von Ardini, Elena, Banfi, Patrizia, Avanzi, Nilla, Ciomei, Marina, Polucci, Paolo, Cirla, Alessandra, D'Anello, Matteo, Borgia, Andrea Lombardi, Motto, Ilaria, Cristiani, Cinzia, Ballinari, Dario, Felder, Eduard, Donati, Daniele, Galvani, Arturo, Isacchi, Antonella, Menichincheri, Maria

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Discovery of 2‑(Cyclohexylmethylamino)pyrimidines as a New Class of Reversible Valosine Containing Protein Inhibitors von Cervi, Giovanni, Magnaghi, Paola, Asa, Daniela, Avanzi, Nilla, Badari, Alessandra, Borghi, Daniela, Caruso, Michele, Cirla, Alessandra, Cozzi, Liviana, Felder, Eduard, Galvani, Arturo, Gasparri, Fabio, Lomolino, Antonio, Magnuson, Steven, Malgesini, Beatrice, Motto, Ilaria, Pasi, Maurizio, Rizzi, Simona, Salom, Barbara, Sorrentino, Graziella, Troiani, Sonia, Valsasina, Barbara, O’Brien, Thomas, Isacchi, Antonella, Donati, Daniele, D’Alessio, Roberto

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Abstract 2082: NMS-E668, a potent and selective RET kinase inhibitor characterized by specificity towards VEGFR2 and high antitumor efficacy against RET-driven models von Ardini, Elena, Banfi, Patrizia, Avanzi, Nilla, Ciomei, Marina, Polucci, Paolo, Cirla, Alessandra, Ermoli, Antonella, Motto, Ilaria, Casale, Elena, Canevari, Giulia, Cristiani, Cinzia, Troiani, Sonia, Sirtori, Federico Riccardi, Amboldi, Nadia, Ballinari, Dario, Caprera, Francesco, Felder, Eduard, Galvani, Arturo, Donati, Daniele, Isacchi, Antonella, Menichincheri, Maria

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Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors von Brasca, Maria Gabriella, Nesi, Marcella, Avanzi, Nilla, Ballinari, Dario, Bandiera, Tiziano, Bertrand, Jay, Bindi, Simona, Canevari, Giulia, Carenzi, Davide, Casero, Daniele, Ceriani, Lucio, Ciomei, Marina, Cirla, Alessandra, Colombo, Maristella, Cribioli, Sabrina, Cristiani, Cinzia, Della Vedova, Franco, Fachin, Gabriele, Fasolini, Marina, Felder, Eduard R., Galvani, Arturo, Isacchi, Antonella, Mirizzi, Danilo, Motto, Ilaria, Panzeri, Achille, Pesenti, Enrico, Vianello, Paola, Gnocchi, Paola, Donati, Daniele

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Abstract 2851: Preclinical characterization of NMS-P648, a novel and potent PARP-1/-3 inhibitor von Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Cirla, Alessandra, Ciavolella, Antonella, Albanese, Clara, Modugno, Michele, Bosotti, Roberta, Somaschini, Alessio, Carapezza, Giovanni, Lupi, Rosita, Ballinari, Dario, Ciomei, Marina, Pesenti, Enrico, Donati, Daniele, Isacchi, Antonella, Galvani, Arturo

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Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1 H -isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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Abstract 1775: Characterization of new highly selective and potent PARP-1 inhibitors von Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Ciavolella, Antonella, Sola, Francesco, Lupi, Rosita, Ciomei, Marina, Cirla, Alessandra, Scolaro, Alessandra, Posteri, Helena, Donati, Daniele, Felder, Eduard, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo

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Synthesis of analogues of calicheamicin and neocarzinostatin chromophore von Cirla, Alessandra, McHale, Angela R, Mann, John

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First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery von Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes

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3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS von PAPEO, Gianluca Mariano Enrico, CIRLA, Alessandra, D'ANELLO, Matteo, SCOLARO, Alessandra, ZUCCOTTO, Fabio

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Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors von Cirla Alessandra, Scolaro Alessandra, Vanotti Ermes, Menichincheri Maria, Forte Barbara, Ermoli Antonella, Pillan Antonio, Caldarelli Marina

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3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors von Cirla, Alessandra, Scolaro, Alessandra, Zuccotto, Fabio, Papeo, Gianluca Mariano Enrico, D'Anello, Matteo

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Combretastatins: From Natural Products to Drug Discovery von Cirla, Alessandra, Mann, John

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