Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors von Beyett, Tyler S., To, Ciric, Heppner, David E., Rana, Jaimin K., Schmoker, Anna M., Jang, Jaebong, De Clercq, Dries J. H., Gomez, Gabriel, Scott, David A., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J.

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Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations von Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.

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EGFR-Mutated Lung Cancers Resistant to Osimertinib through EGFR C797S Respond to First-Generation Reversible EGFR Inhibitors but Eventually Acquire EGFR T790M/C797S in Preclinical... von Rangachari, Deepa, To, Ciric, Shpilsky, Jason E., VanderLaan, Paul A., Kobayashi, Susumu S., Mushajiang, Mierzhati, Lau, Christie J., Paweletz, Cloud P., Oxnard, Geoffrey R., Jänne, Pasi A., Costa, Daniel B.

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Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinog... von To, Ciric, Ringelberg, Carol S, Royce, Darlene B, Williams, Charlotte R, Risingsong, Renee, Sporn, Michael B, Liby, Karen T

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An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer von To, Ciric, Beyett, Tyler S, Jang, Jaebong, Feng, William W, Bahcall, Magda, Haikala, Heidi M, Shin, Bo H, Heppner, David E, Rana, Jaimin K, Leeper, Brittaney A, Soroko, Kara M, Poitras, Michael J, Gokhale, Prafulla C, Kobayashi, Yoshihisa, Wahid, Kamal, Kurppa, Kari J, Gero, Thomas W, Cameron, Michael D, Ogino, Atsuko, Mushajiang, Mierzhati, Xu, Chunxiao, Zhang, Yanxi, Scott, David A, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

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The PARP Inhibitors, Veliparib and Olaparib, Are Effective Chemopreventive Agents for Delaying Mammary Tumor Development in BRCA1-deficient Mice von CIRIC TO, KIM, Eun-Hee, ROYCE, Darlene B, WILLIAMS, Charlotte R, COLLINS, Ryan M, RISINGSONG, Renee, SPORN, Michael B, LIBY, Karen T

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Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality von Li, Zhengnian, Jiang, Jie, Ficarro, Scott B., Beyett, Tyler S., To, Ciric, Tavares, Isidoro, Zhu, Yingde, Li, Jiaqi, Eck, Michael J., Jänne, Pasi A., Marto, Jarrod A., Zhang, Tinghu, Che, Jianwei, Gray, Nathanael S.

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The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy von Bartalena, L, Kahaly, G J, Baldeschi, L, Dayan, C M, Eckstein, A, Marcocci, C, Marinò, M, Vaidya, B, Wiersinga, W M

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Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations von Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.

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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor von To, Ciric, Jang, Jaebong, Chen, Ting, Park, Eunyoung, Mushajiang, Mierzhati, De Clercq, Dries J H, Xu, Man, Wang, Stephen, Cameron, Michael D, Heppner, David E, Shin, Bo Hee, Gero, Thomas W, Yang, Annan, Dahlberg, Suzanne E, Wong, Kwok-Kin, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

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Abstract 30: Intermittent treatment with the PARP inhibitor olaparib delays tumor development in BRCA1-deficient mice von Liby, Karen T., To, Ciric

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Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC von Gero, Thomas W., Heppner, David E., Beyett, Tyler S., To, Ciric, Azevedo, Seth C., Jang, Jaebong, Bunnell, Thomas, Feru, Frederic, Li, Zhengnian, Shin, Bo Hee, Soroko, Kara M., Gokhale, Prafulla C., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J., Scott, David A.

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Discovery of a potent dual ALK and EGFR T790M inhibitor von Jang, Jaebong, Son, Jung Beom, To, Ciric, Bahcall, Magda, Kim, So Young, Kang, Seock Yong, Mushajiang, Mierzhati, Lee, Younho, Jänne, Pasi A., Choi, Hwan Geun, Gray, Nathanael S.

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Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites von Wittlinger, Florian, Heppner, David E, To, Ciric, Günther, Marcel, Shin, Bo Hee, Rana, Jaimin K, Schmoker, Anna M, Beyett, Tyler S, Berger, Lena M, Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D, Corona, Cesear R, Robers, Matthew B, Knapp, Stefan, Jänne, Pasi A, Eck, Michael J, Laufer, Stefan A

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors von De Clercq, Dries J. H, Heppner, David E, To, Ciric, Jang, Jaebong, Park, Eunyoung, Yun, Cai-Hong, Mushajiang, Mierzhati, Shin, Bo Hee, Gero, Thomas W, Scott, David A, Jänne, Pasi A, Eck, Michael J, Gray, Nathanael S

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Existence Theorems for Vector Equilibrium Problems via Quasi-Relative Interior von Adela Elisabeta, Capătă

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Design of a “two-in-one” mutant-selective EGFR inhibitor that spans the orthosteric and allosteric sites von Wittlinger, Florian, Heppner, David E., To, Ciric, Günther, Marcel, Shin, Bo Hee, Rana, Jaimin K., Schmoker, Anna M., Beyett, Tyler S., Berger, Lena M., Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D., Corona, Cesear R., Robers, Matthew B., Knapp, Stefan, Jänne, Pasi A., Eck, Michael J., Laufer, Stefan A.

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Synthetic triterpenoids inhibit GSK3β activity and localization and affect focal adhesions and cell migration von To, Ciric, Roy, Ashbeel, Chan, Eddie, Prado, Marco A.M., Di Guglielmo, Gianni M.

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Synthetic Triterpenoids Target the Arp2/3 Complex and Inhibit Branched Actin Polymerization von To, Ciric, Shilton, Brian H., Di Guglielmo, Gianni M.

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Abstract 466: Synthetic triterpenoids target cell migration and cell adhesion via GSK3β von To, Ciric, Di Guglielmo, Gianni M.

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