Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response von Salvagno, Camilla, Ciampricotti, Metamia, Tuit, Sander, Hau, Cheei-Sing, van Weverwijk, Antoinette, Coffelt, Seth B., Kersten, Kelly, Vrijland, Kim, Kos, Kevin, Ulas, Thomas, Song, Ji-Ying, Ooi, Chia-Huey, Rüttinger, Dominik, Cassier, Philippe A., Jonkers, Jos, Schultze, Joachim L., Ries, Carola H., de Visser, Karin E.

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IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models von Jaspers, Janneke E, Khan, Jonathan F, Godfrey, William D, Lopez, Andrea V, Ciampricotti, Metamia, Rudin, Charles M, Brentjens, Renier J

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Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer von Chan, Joseph M., Quintanal-Villalonga, Álvaro, Gao, Vianne Ran, Xie, Yubin, Allaj, Viola, Chaudhary, Ojasvi, Masilionis, Ignas, Egger, Jacklynn, Chow, Andrew, Walle, Thomas, Mattar, Marissa, Yarlagadda, Dig V.K., Wang, James L., Uddin, Fathema, Offin, Michael, Ciampricotti, Metamia, Qeriqi, Besnik, Bahr, Amber, de Stanchina, Elisa, Bhanot, Umesh K., Lai, W. Victoria, Bott, Matthew J., Jones, David R., Ruiz, Arvin, Baine, Marina K., Li, Yanyun, Rekhtman, Natasha, Poirier, John T., Nawy, Tal, Sen, Triparna, Mazutis, Linas, Hollmann, Travis J., Pe'er, Dana, Rudin, Charles M.

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KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance von Zavitsanou, Anastasia-Maria, Pillai, Ray, Hao, Yuan, Wu, Warren L., Bartnicki, Eric, Karakousi, Triantafyllia, Rajalingam, Sahith, Herrera, Alberto, Karatza, Angeliki, Rashidfarrokhi, Ali, Solis, Sabrina, Ciampricotti, Metamia, Yeaton, Anna H., Ivanova, Ellie, Wohlhieter, Corrin A., Buus, Terkild B., Hayashi, Makiko, Karadal-Ferrena, Burcu, Pass, Harvey I., Poirier, John T., Rudin, Charles M., Wong, Kwok-Kin, Moreira, Andre L., Khanna, Kamal M., Tsirigos, Aristotelis, Papagiannakopoulos, Thales, Koralov, Sergei B.

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Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland von de Visser, Karin E, Ciampricotti, Metamia, Michalak, Ewa M, Tan, David Wei-Min, Speksnijder, Ewoud N, Hau, Cheei-Sing, Clevers, Hans, Barker, Nick, Jonkers, Jos

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Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages von Kersten, Kelly, Coffelt, Seth B., Hoogstraat, Marlous, Verstegen, Niels J.M., Vrijland, Kim, Ciampricotti, Metamia, Doornebal, Chris W., Hau, Cheei-Sing, Wellenstein, Max D., Salvagno, Camilla, Doshi, Parul, Lips, Esther H., Wessels, Lodewyk F.A., de Visser, Karin E.

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Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system von Ciampricotti, Metamia, Hau, Cheei-Sing, Doornebal, Chris W, Jonkers, Jos, de Visser, Karin E

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Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation von Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Ray-Kirton, Jordana, Egger, Jacklynn D., Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Roehrl, Michael H., Ventura, Katia, Qiu, Juan, de Stanchina, Elisa, Chang, Jason C., Rekhtman, Natasha, Houck-Loomis, Brian, Koche, Richard P., Yu, Helena A., Sen, Triparna, Rudin, Charles M.

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Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation von de Pater, Emma, Ciampricotti, Metamia, Priller, Florian, Veerkamp, Justus, Strate, Ina, Smith, Kelly, Lagendijk, Anne Karine, Schilling, Thomas F, Herzog, Wiebke, Abdelilah-Seyfried, Salim, Hammerschmidt, Matthias, Bakkers, Jeroen

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A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis von DOORNEBAL, Chris W, KLARENBEEK, Sjoerd, BRAUMULLER, Tanya M, KLIJN, Christiaan N, CIAMPRICOTTI, Metamia, HAU, Cheei-Sing, HOLLMANN, Markus W, JONKERS, Jos, DE VISSER, Karin E

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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation von Quintanal-Villalonga, Alvaro, Kawasaki, Kenta, Redin, Esther, Uddin, Fathema, Rakhade, Swanand, Durani, Vidushi, Sabet, Amin, Shafer, Moniquetta, Karthaus, Wouter R., Zaidi, Samir, Zhan, Yingqian A., Manoj, Parvathy, Sridhar, Harsha, Kinyua, Dennis, Zhong, Hong, Mello, Barbara P., Ciampricotti, Metamia, Bhanot, Umesh K., Linkov, Irina, Qiu, Juan, Patel, Radhika A., Morrissey, Colm, Mehta, Sanjoy, Barnes, Jesse, Haffner, Michael C., Socci, Nicholas D., Koche, Richard P., de Stanchina, Elisa, Molina-Pinelo, Sonia, Salehi, Sohrab, Yu, Helena A., Chan, Joseph M., Rudin, Charles M.

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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer von Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis von Coffelt, Seth B., Kersten, Kelly, Doornebal, Chris W., Weiden, Jorieke, Vrijland, Kim, Hau, Cheei-Sing, Verstegen, Niels J. M., Ciampricotti, Metamia, Hawinkels, Lukas J. A. C., Jonkers, Jos, de Visser, Karin E.

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer von Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

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Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation von Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T. A., Won, Helen H., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C., Ray-Kirton, Jordana, Tischfield, Sam E., Egger, Jacklynn, Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A., Roehrl, Michael H., Hollmann, Travis J., Yu, Helena A., Qiu, Juan, de Stanchina, Elisa, Baine, Marina K., Rekhtman, Natasha, Poirier, John T., Loomis, Brian, Koche, Richard P., Rudin, Charles M., Sen, Triparna

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Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy von Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Hao, Yuan, Chow, Andrew, Zhan, Yingqian A, Chavan, Shweta S, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S, Chan, Joseph M, Offin, Michael, Ciampricotti, Metamia, Ray-Kirton, Jordana, Egger, Jacklynn, Bhanot, Umesh, Linkov, Irina, Asher, Marina, Roehrl, Michael H, Qiu, Juan, de Stanchina, Elisa, Hollmann, Travis J, Koche, Richard P, Sen, Triparna, Poirier, John T, Rudin, Charles M

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Abstract 420: Rlf-Mycl1 gene fusion as a novel oncogenic driver in a mouse model of small cell lung cancer von Ciampricotti, Metamia, Karakousi, Triantafyllia, Villalonga, Alvaro Quintanal, Allaj, Viola, Ventura, Andrea, Sen, Triparna, Poirier, JT, Papagiannakopoulos, Thales, Rudin, Charles M.

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Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer von Ciampricotti, Metamia, Karakousi, Triantafyllia, Richards, Allison L., Quintanal-Villalonga, Alvaro, Karatza, Angeliki, Caeser, Rebecca, Costa, Emily A., Allaj, Viola, Manoj, Parvathy, Spainhower, Kyle B., Kombak, Faruk E., Sanchez-Rivera, Francisco J., Jaspers, Janneke E., Zavitsanou, Anastasia-Maria, Maddalo, Danilo, Ventura, Andrea, Rideout, William M., Akama-Garren, Elliot H., Jacks, Tyler, Donoghue, Mark T. A., Sen, Triparna, Oliver, Trudy G., Poirier, John T., Papagiannakopoulos, Thales, Rudin, Charles M.

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Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer von Doornebal, Chris W., Vrijland, Kim, Hau, Cheei-Sing, Coffelt, Seth B., Ciampricotti, Metamia, Jonkers, Jos, de Visser, Karin E., Hollmann, Markus W.

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Article MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer von Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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