Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy von Lee, Joong-jae, Choi, Hyo-Jung, Yun, Misun, Kang, YingJin, Jung, Ji-Eun, Ryu, Yiseul, Kim, Tae Yoon, Cha, Young-je, Cho, Hyun-Soo, Min, Jung-Joon, Chung, Chul-Woong, Kim, Hak-Sung

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IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux von Lee, Huikyong, Noh, Jee-Yeon, Oh, Yumin, Kim, Youngdoo, Chang, Jae-Woong, Chung, Chul-Woong, Lee, Soon-Tae, Kim, Manho, Ryu, Hoon, Jung, Yong-Keun

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An Elaborate New Linker System Significantly Enhances the Efficacy of an HER2‐Antibody‐Drug Conjugate against Refractory HER2‐Positive Cancers von Shin, Seol Hwa, Park, Yun‐Hee, Park, Seok Soon, Ju, Eun Jin, Park, Jin, Ko, Eun Jung, Bae, Dong Jun, Kim, Sang‐Yeob, Chung, Chul‐Woong, Song, Ho Young, Jang, Se Jin, Jeong, Seong‐Yun, Song, Si Yeol, Choi, Eun Kyung

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SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition von Noh, Jee-Yeon, Lee, Huikyong, Song, Sungmin, Kim, Nam Soon, Im, Wooseok, Kim, Manho, Seo, Hyemyung, Chung, Chul-Woong, Chang, Jae-Woong, Ferrante, Robert J., Yoo, Young-Jun, Ryu, Hoon, Jung, Yong-Keun

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Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53 von Kim, Hyo-Jin, Lee, Ho-June, Jun, Joon-Il, Oh, Yumin, Choi, Seon-Guk, Kim, Hyunjoo, Chung, Chul-Woong, Kim, In-Ki, Park, Il-Sun, Chae, Han-Jung, Kim, Hyung-Ryong, Jung, Yong-Keun

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Cleavage of Bax is mediated by caspase‐dependent or ‐independent calpain activation in dopaminergic neuronal cells: protective role of Bcl‐2 von Choi, Won‐Seok, Lee, Eun‐Hee, Chung, Chul‐Woong, Jung, Yong‐Keun, Jin, Byung K., Kim, Seung U., Oh, Tae H., Saido, Takaomi C., Oh, Young J.

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Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3 von Chung, Chul-Woong, Song, Yu-Hyun, Kim, In-Ki, Yoon, Won-Joo, Ryu, Bo-Rum, Jo, Dong-Gyu, Woo, Ha-Na, Kwon, Yun-Kyong, Kim, Hyun-Hee, Gwag, Byoung-Joo, Mook-Jung, In-Hee, Jung, Yong-Keun

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A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening von Kim, Young Hun, Kim, Minsung, Yoo, Miyoun, Kim, Ji Eun, Lee, Heung Kyoung, Heo, Jung-Nyoung, Lee, Chong Ock, Yoo, Minjin, Jung, Kwan-Young, Yun, Chang-Soo, Moon, Sung Woong, Chang, Hye Kyung, Chung, Chul-Woong, Pyo, Suhkneung, Choi, Sang Un, Park, Chi Hoon

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1154 Anti-PD-L1 antibody-immune modulator conjugates significantly enhance anti-tumor activity in syngeneic models von Lim, Soyeon, Park, Yun-Hee, Kim, Myeong Joo, Han, Na Ra, Song, Ho Young, Chung, Chul-Woong

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An Anti-apoptotic Protein Human Survivin Is a Direct Inhibitor of Caspase-3 and -7 von Shin, Sejeong, Sung, Byung-Je, Cho, Yong-Soon, Kim, Hyun-Ju, Ha, Nam-Chul, Hwang, Jong-Ik, Chung, Chul-Woong, Jung, Yong-Keun, Oh, Byung-Ha

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897 AST-301, a pDNA-based cancer vaccine encoding HER2-ICD, enhances anti-tumor effect of HER2-ADC in a HER2-expressed gastric cancer xenograft model von Kang, JinHo, Park, Hyo-Hyun, Choi, Jee Hyun, Lim, Jinback, Jang, Seong-Yong, Kim, Min-Ah, Park, Myeong-Kyu, Park, Yun-Hee, Lim, Soyeon, Chung, Chul-Woong, Choi, Jin Kyeong, Joung, Eunkyo, Jung, Hun

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1414 Antitumor effect of HER2-hICD vaccine combining with HER2 ADC depending on T cell existence in a mouse model: pooled analysis von Kang, JinHo, Park, Hyo-Hyun, Choi, Jee Hyun, Lim, Jinback, Kim, Hye-Ran, Jang, Seong-Yong, Kim, Min-Ah, Park, Myeong-Kyu, Park, Yun-Hee, Lim, Soyeon, Chung, Chul-Woong, Choi, Jin Kyeong, Joung, Eunkyo, Jung, Hun

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E2-25K/Hip-2 Regulates Caspase-12 in ER Stress-Mediated aβ Neurotoxicity von Song, Sungmin, Lee, Huikyong, Kam, Tae-In, Tai, Mei Ling, Lee, Joo-Yong, Noh, Jee-Yeon, Shim, Sang Mi, Seo, Soo Jung, Kong, Young-Yun, Nakagawa, Toshiyuki, Chung, Chul-Woong, Choi, Deog-Young, Oubrahim, Hammou, Jung, Yong-Keun

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NecroX as a novel class of mitochondrial reactive oxygen species and ONOO− scavenger von Kim, Hyoung Jin, Koo, Sun Young, Ahn, Bong-Hyun, Park, Oeuk, Park, Doo Hoe, Seo, Dong Ook, Won, Jong Heon, Yim, Hyeon Joo, Kwak, Hyo-Shin, Park, Heui Sul, Chung, Chul Woong, Oh, Young Leem, Kim, Soon Ha

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Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity von Song, Sungmin, Kim, So-Young, Hong, Yeon-Mi, Jo, Dong-Gyu, Lee, Joo-Yong, Shim, Sang Mi, Chung, Chul-Woong, Seo, Soo Jung, Yoo, Yung Joon, Koh, Jae-Young, Lee, Min Chul, Yates, Allan J, Ichijo, Hidenori, Jung, Yong-Keun

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Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death von Chung, Chul-Woong, Hong, Yeon-Mi, Song, Sungmin, Woo, Ha-Na, Choi, Yun-Hee, Rohn, Troy, Jung, Yong-Keun

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Caspase cleavage product lacking amino-terminus of IκBα sensitizes resistant cells to TNF-α and TRAIL-induced apoptosis von Kim, Ki-Woo, Kim, Byung Ju, Chung, Chul-Woong, Jo, Dong-Gyu, Kim, In-Ki, Song, You-Hyun, Kwon, Yun-Kyung, Woo, Ha-Na, Jung, Yong-Keun

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Considering Cell-based Assays and Factors for Genome-wide High-content Functional Screening von Chung, C.W. (LG Life Science Research Park, Daejeon, Republic of Korea), Kim, I.K. (Ontario Cancer Institute, Toronto, Canada), Jung, Y.K. (Seoul National University, Seoul, Republic of Korea), E-mail: ykjung@snu.ac.kr

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Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy von Lee, Joong-jae, Choi, Hyo-Jung, Yun, Misun, Kang, YingJin, Jung, Ji-Eun, Ryu, Yiseul, Kim, Tae Yoon, Cha, Young-je, Cho, Hyun-Soo, Min, Jung-Joon, Chung, Chul-Woong, Kim, Hak-Sung

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IKS03, a Next Generation CD19-Targeted Antibody Drug Conjugate, Shows Potent Activity in Preclinical Models of Aggressive B-Cell Lymphomas von Deckert, Jutta, Thirlway, Jenny, Mysliwy, Justyna, Lodge, Adam, Park, Yun-Hee, Ryu, Hyun-Min, Han, Na Ra, Song, Ho Young, Chung, Chul-Woong, Lutz, Robert J

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