Small molecule induced reactivation of mutant p53 in cancer cells von Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C, Chuckowree, Irina S, Amin, Jahangir, Spencer, John, Fersht, Alan R

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The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable... von Folkes, Adrian J, Ahmadi, Khatereh, Alderton, Wendy K, Alix, Sonia, Baker, Stewart J, Box, Gary, Chuckowree, Irina S, Clarke, Paul A, Depledge, Paul, Eccles, Suzanne A, Friedman, Lori S, Hayes, Angela, Hancox, Timothy C, Kugendradas, Arumugam, Lensun, Letitia, Moore, Pauline, Olivero, Alan G, Pang, Jodie, Patel, Sonal, Pergl-Wilson, Giles H, Raynaud, Florence I, Robson, Anthony, Saghir, Nahid, Salphati, Laurent, Sohal, Sukhjit, Ultsch, Mark H, Valenti, Melanie, Wallweber, Heidi J.A, Wan, Nan Chi, Wiesmann, Christian, Workman, Paul, Zhyvoloup, Alexander, Zvelebil, Marketa J, Shuttleworth, Stephen J

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Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer C... von Longo, Alessandra, Librizzi, Mariangela, Chuckowree, Irina S, Baltus, Christine B, Spencer, John, Luparello, Claudio

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941 von Raynaud, Florence I, Eccles, Suzanne A, Patel, Sonal, Alix, Sonia, Box, Gary, Chuckowree, Irina, Folkes, Adrian, Gowan, Sharon, De Haven Brandon, Alexis, Di Stefano, Francesca, Hayes, Angela, Henley, Alan T, Lensun, Letitia, Pergl-Wilson, Giles, Robson, Anthony, Saghir, Nahid, Zhyvoloup, Alexander, McDonald, Edward, Sheldrake, Peter, Shuttleworth, Stephen, Valenti, Melanie, Wan, Nan Chi, Clarke, Paul A, Workman, Paul

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Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups von Amin, Jahangir, Chuckowree, Irina S, Wang, Minghua, Tizzard, Graham J, Coles, Simon J, Spencer, John

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Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer von Sutherlin, Daniel P, Sampath, Deepak, Berry, Megan, Castanedo, Georgette, Chang, Zhigang, Chuckowree, Irina, Dotson, Jenna, Folkes, Adrian, Friedman, Lori, Goldsmith, Richard, Heffron, Tim, Lee, Leslie, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Wong, Susan, Zhu, Bing-Yan

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Olefin cross-metathesis/Suzuki–Miyaura reactions on vinylphenylboronic acid pinacol esters von Baltus, Christine B., Chuckowree, Irina S., Press, Neil J., Day, Iain J., Coles, Simon J., Tizzard, Graham J., Spencer, John

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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor von Heffron, Timothy P., Berry, Megan, Castanedo, Georgette, Chang, Christine, Chuckowree, Irina, Dotson, Jennafer, Folkes, Adrian, Gunzner, Janet, Lesnick, John D., Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Peterson, David, Salphati, Laurent, Sampath, Deepak, Sideris, Steve, Sutherlin, Daniel P., Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wong, Susan, Zhu, Bing-yan

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Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells von Bagley, Mark C, Baashen, Mohammed, Chuckowree, Irina, Dwyer, Jessica E, Kipling, David, Davis, Terence

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Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library von Chuckowree, Irina, Ali Syed, Murtaza, Getti, Giulia, Parbhu Patel, Asha, Garner, Hannah, Tizzard, Graham J., Coles, Simon J., Spencer, John

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Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase von Staben, Steven T., Heffron, Timothy P., Sutherlin, Daniel P., Bhat, Seema R., Castanedo, Georgette M., Chuckowree, Irina S., Dotson, Jenna, Folkes, Adrian J., Friedman, Lori S., Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Olivero, Alan G., Plise, Emile, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Rouge, Lionel, Sampath, Deepak, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Weismann, Christian, Wu, Ping, Zhu, Bing-Yan

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Novel Angular Benzophenazines:  Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents von Vicker, Nigel, Burgess, Luke, Chuckowree, Irina S, Dodd, Rory, Folkes, Adrian J, Hardick, David J, Hancox, Timothy C, Miller, Warren, Milton, John, Sohal, Sukhjit, Wang, Shouming, Wren, Stephen P, Charlton, Peter A, Dangerfield, Wendy, Liddle, Chris, Mistry, Prakash, Stewart, Alistair J, Denny, William A

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Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion von Cockerill, G. Stuart, Angell, Richard M, Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A, Good, James A. D, Harland, Rachel, Johnson, Sara M, Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S, Paradowski, Michael, Peeples, Mark E, Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E, Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth

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Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatme... von Sutherlin, Daniel P, Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Murray, Jeremy, Nonomiya, Jim, Pang, Jodie, Pegg, Niel, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wei, BinQing, Wiesmann, Christian, Wu, Ping, Zhu, Bing-Yan, Olivero, Alan

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Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors von Phuangsawai, Oraphan, Beswick, Paul, Ratanabunyong, Siriluk, Tabtimmai, Lueacha, Suphakun, Praphasri, Obounchoey, Phongphat, Srisook, Pimonwan, Horata, Natharinee, Chuckowree, Irina, Hannongbua, Supa, Ward, Simon E., Choowongkomon, Kiattawee, Gleeson, M. Paul

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Abstract 2472: Small-molecule-induced reactivation of mutant p53 in cancer cells von Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas, Chuckowree, Irina, Spencer, John, Fersht, Alan

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Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors von Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J, Coles, Simon J, Wang, Minghua, Bingham, John P, Hartley, John A, Spencer, John

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Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors von Patel, Hiren, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Wang, Minghua, Zuckermann, Alexandra, Williams, Robin S. B., Librizzi, Mariangela, Paranal, Ronald M., Bradner, James E., Spencer, John

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Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance von Wang, Shouming, Folkes, Adrian, Chuckowree, Irina, Cockcroft, Xiaoling, Sohal, Sukhjit, Miller, Warren, Milton, John, Wren, Stephen P, Vicker, Nigel, Depledge, Paul, Scott, John, Smith, Lyndsay, Jones, Hazel, Mistry, Prakash, Faint, Richard, Thompson, Deanne, Cocks, Simon

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Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitorsElectronic supplementary information (ESI) available: Synthesis of hybrids, cell-based assay... von Patel, Hiren, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Wang, Minghua, Zuckermann, Alexandra, Williams, Robin S. B, Librizzi, Mariangela, Paranal, Ronald M, Bradner, James E, Spencer, John

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