Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain von Akçay, Gizem, Belmonte, Matthew A, Aquila, Brian, Chuaqui, Claudio, Hird, Alexander W, Lamb, Michelle L, Rawlins, Philip B, Su, Nancy, Tentarelli, Sharon, Grimster, Neil P, Su, Qibin

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Structural Interaction Fingerprint (SIFt):  A Novel Method for Analyzing Three-Dimensional Protein−Ligand Binding Interactions von Deng, Zhan, Chuaqui, Claudio, Singh, Juswinder

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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kin... von Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR) von Ward, Richard A, Anderton, Mark J, Ashton, Susan, Bethel, Paul A, Box, Matthew, Butterworth, Sam, Colclough, Nicola, Chorley, Christopher G, Chuaqui, Claudio, Cross, Darren A. E, Dakin, Les A, Debreczeni, Judit É, Eberlein, Cath, Finlay, M. Raymond V, Hill, George B, Grist, Matthew, Klinowska, Teresa C. M, Lane, Clare, Martin, Scott, Orme, Jonathon P, Smith, Peter, Wang, Fengjiang, Waring, Michael J

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Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1 von Wu, Jiaquan, Mikule, Keith, Wang, Wenxian, Su, Nancy, Petteruti, Philip, Gharahdaghi, Farzin, Code, Erin, Zhu, Xiahui, Jacques, Kelly, Lai, Zhongwu, Yang, Bin, Lamb, Michelle L, Chuaqui, Claudio, Keen, Nicholas, Chen, Huawei

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Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Jan... von Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G

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Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening von Yang, Bin, Lamb, Michelle L, Zhang, Tao, Hennessy, Edward J, Grewal, Gurmit, Sha, Li, Zambrowski, Mark, Block, Michael H, Dowling, James E, Su, Nancy, Wu, Jiaquan, Deegan, Tracy, Mikule, Keith, Wang, Wenxian, Kaspera, Rüdiger, Chuaqui, Claudio, Chen, Huawei

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Abstract 979: Discovery of the JAK1 selective kinase inhibitor AZD4205 von Kettle, Jason G., Su, Qibin, Grimster, Neil, Kawatkar, Sameer, Throner, Scott, Woessner, Richard, Chen, Huawei, Bebernitz, Geraldine, Bell, Kristen, Anderson, Erica, Ruston, Linette, Winter-Holt, Jon, Lyne, Paul, Vasbinder, Melissa, Chuaqui, Claudio

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Position Specific Interaction Dependent Scoring Technique for Virtual Screening Based on Weighted Protein−Ligand Interaction Fingerprint Profiles von Nandigam, Ravi K, Kim, Sangtae, Singh, Juswinder, Chuaqui, Claudio

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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI) von JUSWINDER SINGH, CHUAQUI, Claudio E, PAPADATOS, James L, BOWES, Scott, JOSIAH, Serene, LING, Leona E, BORIACK-SJODIN, P. Ann, LEE, Wen-Cherng, PONTZ, Timothy, CORBLEY, Michael J, CHEUNG, H.-Kam, ARDUINI, Robert M, MEAD, Jonathan N, NEWMAN, Miki N

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SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model von Fu, Kai, Corbley, Michael J, Sun, Lihong, Friedman, Jessica E, Shan, Feng, Papadatos, James L, Costa, Donald, Lutterodt, Frank, Sweigard, Harry, Bowes, Scott, Choi, Michael, Boriack-Sjodin, P Ann, Arduini, Robert M, Sun, Dongyu, Newman, Miki N, Zhang, Xiamei, Mead, Jonathan N, Chuaqui, Claudio E, Cheung, H-Kam, Zhang, Xin, Cornebise, Mark, Carter, Mary Beth, Josiah, Serene, Singh, Juswinder, Lee, Wen-Cherng, Gill, Alan, Ling, Leona E

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Structural Interaction Fingerprints: A New Approach to Organizing, Mining, Analyzing, and Designing Protein-Small Molecule Complexes von Singh, Juswinder, Deng, Zhan, Narale, Gaurav, Chuaqui, Claudio

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Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7 von Marineau, Jason J, Hamman, Kristin B, Hu, Shanhu, Alnemy, Sydney, Mihalich, Janessa, Kabro, Anzhelika, Whitmore, Kenneth Matthew, Winter, Dana K, Roy, Stephanie, Ciblat, Stephane, Ke, Nan, Savinainen, Anneli, Wilsily, Ashraf, Malojcic, Goran, Zahler, Robert, Schmidt, Darby, Bradley, Michael J, Waters, Nigel J, Chuaqui, Claudio

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Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo von Hu, Shanhu, Marineau, Jason, Hamman, Kristin, Bradley, Michael, Savinainen, Anneli, Alnemy, Sydney, Rajagopal, Nisha, Orlando, David, Chuaqui, Claudio, Olson, Eric

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Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors von McCoull, William, Abrams, Roman D, Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J, Cheung, Tony, Code, Erin, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R, Hu, Jun, Kemmitt, Paul D, Nelson, Jennifer E, O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B, Robb, Graeme R, Shi, Junjie, Waring, Michael J, Whittaker, David, Wylot, Marta, Zhu, Xiahui

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Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A., Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders von Malona, JOHN, CHUAQUI, CLAUDIO, SELETSKY, BORIS M., BEEBE, LISA, CANTIN, SUSAN, KALKEN, DANIEL VAN, FAHNOE, KELLY, WANG, ZHIGANG, BROWNING, BETH, SZABO, HILARY, KOOPMAN, LOUISE A., ORAVECZ, TAMAS, MCDONALD, JOSEPH J., RAMIREZ-VALLE, FRANCISCO, GAUR, RAJULA, MENSAH, KOFI A., THOMAS, MICHAEL, CONNARN, JAMIE N., HU, HAIQING, ALEXANDER, MATTHEW D., CORIN, ALAN F.

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Interaction Profiles of Protein Kinase−Inhibitor Complexes and Their Application to Virtual Screening von Chuaqui, Claudio, Deng, Zhan, Singh, Juswinder

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Discovery of 1‑Methyl‑1H‑imidazole Derivatives as Potent Jak2 Inhibitors von Su, Qibin, Ioannidis, Stephanos, Chuaqui, Claudio, Almeida, Lynsie, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Block, Michael, Howard, Tina, Huang, Shan, Huszar, Dennis, Read, Jon A, Rivard Costa, Caroline, Shi, Jie, Su, Mei, Ye, Minwei, Zinda, Michael

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A Kinase-focused Compound Collection: Compilation and Screening Strategy von Sun, Dongyu, Chuaqui, Claudio, Deng, Zhan, Bowes, Scott, Chin, Donovan, Singh, Juswinder, Cullen, Patrick, Hankins, Gretchen, Lee, Wen-Cherng, Donnelly, Jason, Friedman, Jessica, Josiah, Serene

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