Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains von Zhou, Tongqing, Tsybovsky, Yaroslav, Gorman, Jason, Rapp, Micah, Cerutti, Gabriele, Chuang, Gwo-Yu, Katsamba, Phinikoula S., Sampson, Jared M., Schön, Arne, Bimela, Jude, Boyington, Jeffrey C., Nazzari, Alexandra, Olia, Adam S., Shi, Wei, Sastry, Mallika, Stephens, Tyler, Stuckey, Jonathan, Teng, I-Ting, Wang, Pengfei, Wang, Shuishu, Zhang, Baoshan, Friesner, Richard A., Ho, David D., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.

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Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants von Xu, Jianliang, Xu, Kai, Jung, Seolkyoung, Conte, Andrea, Lieberman, Jenna, Muecksch, Frauke, Lorenzi, Julio Cesar Cetrulo, Park, Solji, Schmidt, Fabian, Wang, Zijun, Huang, Yaoxing, Luo, Yang, Nair, Manoj S., Wang, Pengfei, Schulz, Jonathan E., Tessarollo, Lino, Bylund, Tatsiana, Chuang, Gwo-Yu, Olia, Adam S., Stephens, Tyler, Teng, I-Ting, Tsybovsky, Yaroslav, Zhou, Tongqing, Munster, Vincent, Ho, David D., Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., Kwong, Peter D., Casellas, Rafael

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Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus von McLellan, Jason S., Chen, Man, Joyce, M. Gordon, Sastry, Mallika, Stewart-Jones, Guillaume B. E., Yang, Yongping, Zhang, Baoshan, Chen, Lei, Srivatsan, Sanjay, Zheng, Anqi, Zhou, Tongqing, Graepel, Kevin W., Kumar, Azad, Moin, Syed, Boyington, Jeffrey C., Chuang, Gwo-Yu, Soto, Cinque, Baxa, Ulrich, Bakker, Arjen Q., Spits, Hergen, Beaumont, Tim, Zheng, Zizheng, Xia, Ningshao, Ko, Sung-Youl, Todd, John-Paul, Rao, Srinivas, Graham, Barney S., Kwong, Peter D.

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mtx-COBRA: Subcellular localization prediction for bacterial proteins von Arora, Isha, Kummer, Arkadij, Zhou, Hao, Gadjeva, Mihaela, Ma, Eric, Chuang, Gwo-Yu, Ong, Edison

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Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry von Lai, Yen-Ting, Wang, Tao, O’Dell, Sijy, Louder, Mark K., Schön, Arne, Cheung, Crystal S. F., Chuang, Gwo-Yu, Druz, Aliaksandr, Lin, Bob, McKee, Krisha, Peng, Dongjun, Yang, Yongping, Zhang, Baoshan, Herschhorn, Alon, Sodroski, Joseph, Bailer, Robert T., Doria-Rose, Nicole A., Mascola, John R., Langley, David R., Kwong, Peter D.

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Fragment-based identification of druggable ‘hot spots’ of proteins using Fourier domain correlation techniques von Brenke, Ryan, Kozakov, Dima, Chuang, Gwo-Yu, Beglov, Dmitri, Hall, David, Landon, Melissa R., Mattos, Carla, Vajda, Sandor

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Structural conservation of druggable hot spots in protein–protein interfaces von Kozakov, Dima, Hall, David R, Chuang, Gwo-Yu, Cencic, Regina, Brenke, Ryan, Grove, Laurie E, Beglov, Dmitri, Pelletier, Jerry, Whitty, Adrian, Vajda, Sandor

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Application of asymmetric statistical potentials to antibody―protein docking von BRENKE, Ryan, HALL, David R, CHUANG, Gwo-Yu, COMEAU, Stephen R, BOHNUUD, Tanggis, BEGLOV, Dmitri, SCHUELER-FURMAN, Ora, VAJDA, Sandor, KOZAKOV, Dima

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Improvement of antibody functionality by structure-guided paratope engraftment von Liu, Qingbo, Lai, Yen-Ting, Zhang, Peng, Louder, Mark K., Pegu, Amarendra, Rawi, Reda, Asokan, Mangaiarkarasi, Chen, Xuejun, Shen, Chen-Hsiang, Chuang, Gwo-Yu, Yang, Eun Sung, Miao, Huiyi, Wang, Yuge, Fauci, Anthony S., Kwong, Peter D., Mascola, John R., Lusso, Paolo

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Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth von Chen, Xuejun, Zhou, Tongqing, Schmidt, Stephen D., Duan, Hongying, Cheng, Cheng, Chuang, Gwo-Yu, Gu, Ying, Louder, Mark K., Lin, Bob C., Shen, Chen-Hsiang, Sheng, Zizhang, Zheng, Michelle X., Doria-Rose, Nicole A., Joyce, M. Gordon, Shapiro, Lawrence, Tian, Ming, Alt, Frederick W., Kwong, Peter D., Mascola, John R.

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Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition von Chuang, Gwo-Yu, Zhou, Jing, Acharya, Priyamvada, Rawi, Reda, Shen, Chen-Hsiang, Sheng, Zizhang, Zhang, Baoshan, Zhou, Tongqing, Bailer, Robert T., Dandey, Venkata P., Doria-Rose, Nicole A., Louder, Mark K., McKee, Krisha, Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.

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A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers von Rutten, Lucy, Lai, Yen-Ting, Blokland, Sven, Truan, Daphne, Bisschop, Ilona J.M., Strokappe, Nika M., Koornneef, Annemart, van Manen, Danielle, Chuang, Gwo-Yu, Farney, S. Katie, Schuitemaker, Hanneke, Kwong, Peter D., Langedijk, Johannes P.M.

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Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces von Lee, Myungjin, Changela, Anita, Gorman, Jason, Rawi, Reda, Bylund, Tatsiana, Chao, Cara W., Lin, Bob C., Louder, Mark K., Olia, Adam S., Zhang, Baoshan, Doria-Rose, Nicole A., Zolla-Pazner, Susan, Shapiro, Lawrence, Chuang, Gwo-Yu, Kwong, Peter D.

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Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV von Joyce, M Gordon, Zhang, Baoshan, Ou, Li, Chen, Man, Chuang, Gwo-Yu, Druz, Aliaksandr, Kong, Wing-Pui, Lai, Yen-Ting, Rundlet, Emily J, Tsybovsky, Yaroslav, Yang, Yongping, Georgiev, Ivelin S, Guttman, Miklos, Lees, Christopher R, Pancera, Marie, Sastry, Mallika, Soto, Cinque, Stewart-Jones, Guillaume B E, Thomas, Paul V, Van Galen, Joseph G, Baxa, Ulrich, Lee, Kelly K, Mascola, John R, Graham, Barney S, Kwong, Peter D

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs von Xu, Kai, Wang, Yiran, Shen, Chen-Hsiang, Chen, Yiwei, Zhang, Baoshan, Liu, Kevin, Tsybovsky, Yaroslav, Wang, Shuishu, Farney, S. Katie, Gorman, Jason, Stephens, Tyler, Verardi, Raffaello, Yang, Yongping, Zhou, Tongqing, Chuang, Gwo-Yu, Lanzavecchia, Antonio, Piccoli, Luca, Kwong, Peter D.

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Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates von Rawi, Reda, Mall, Raghvendra, Shen, Chen-Hsiang, Farney, S. Katie, Shiakolas, Andrea, Zhou, Jing, Bensmail, Halima, Chun, Tae-Wook, Doria-Rose, Nicole A., Lynch, Rebecca M., Mascola, John R., Kwong, Peter D., Chuang, Gwo-Yu

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Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization von Georgiev, Ivelin S., Doria-Rose, Nicole A., Zhou, Tongqing, Kwon, Young Do, Staupe, Ryan P., Moquin, Stephanie, Chuang, Gwo-Yu, Louder, Mark K., Schmidt, Stephen D., Altae-Tran, Han R., Bailer, Robert T., McKee, Krisha, Nason, Martha, O'Dell, Sijy, Ofek, Gilad, Pancera, Marie, Srivatsan, Sanjay, Shapiro, Lawrence, Connors, Mark, Migueles, Stephen A., Morris, Lynn, Nishimura, Yoshiaki, Martin, Malcolm A., Mascola, John R., Kwong, Peter D.

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Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth von Wagh, Kshitij, Kreider, Edward F., Li, Yingying, Barbian, Hannah J., Learn, Gerald H., Giorgi, Elena, Hraber, Peter T., Decker, Timothy G., Smith, Andrew G., Gondim, Marcos V., Gillis, Lindsey, Wandzilak, Jamie, Chuang, Gwo-Yu, Rawi, Reda, Cai, Fangping, Pellegrino, Pierre, Williams, Ian, Overbaugh, Julie, Gao, Feng, Kwong, Peter D., Haynes, Barton F., Shaw, George M., Borrow, Persephone, Seaman, Michael S., Hahn, Beatrice H., Korber, Bette

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Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV von Dingens, Adam S, Acharya, Priyamvada, Haddox, Hugh K, Rawi, Reda, Xu, Kai, Chuang, Gwo-Yu, Wei, Hui, Zhang, Baoshan, Mascola, John R, Carragher, Bridget, Potter, Clinton S, Overbaugh, Julie, Kwong, Peter D, Bloom, Jesse D

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Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting von Cheng, Cheng, Xu, Kai, Kong, Rui, Chuang, Gwo-Yu, Corrigan, Angela R, Geng, Hui, Hill, Kurt R, Jafari, Alexander J, O'Dell, Sijy, Ou, Li, Rawi, Reda, Rowshan, Ariana P, Sarfo, Edward K, Sastry, Mallika, Saunders, Kevin O, Schmidt, Stephen D, Wang, Shuishu, Wu, Winston, Zhang, Baoshan, Doria-Rose, Nicole A, Haynes, Barton F, Scorpio, Diana G, Shapiro, Lawrence, Mascola, John R, Kwong, Peter D

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