Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors von DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M

Volltext

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement von La, Daniel S., Peterson, Emily A., Bode, Christiane, Boezio, Alessandro A., Bregman, Howard, Chu-Moyer, Margaret Y., Coats, James, DiMauro, Erin F., Dineen, Thomas A., Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J., Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S., Marx, Isaac, Matson, David J., McDonough, Stefan I., Moyer, Bryan D., Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M.

Volltext

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement von Marx, Isaac E, Dineen, Thomas A, Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Du, Bingfan, Foti, Robert S, Fremeau, Robert T, Gao, Hua, Gunaydin, Hakan, Hall, Brian E, Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Lin, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S, Moyer, Bryan D, Peterson, Emily A, Roberts, Jonathan T, Rose, Paul, Wang, Jean, Youngblood, Beth D, Yu, Violeta, Weiss, Matthew M

Volltext

The discovery of benzoxazine sulfonamide inhibitors of Na V 1.7: Tools that bridge efficacy and target engagement von La, Daniel S, Peterson, Emily A, Bode, Christiane, Boezio, Alessandro A, Bregman, Howard, Chu-Moyer, Margaret Y, Coats, James, DiMauro, Erin F, Dineen, Thomas A, Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Jr, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J, Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S, Marx, Isaac, Matson, David J, McDonough, Stefan I, Moyer, Bryan D, Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M

Volltext

Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors:  Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-P... von Chu-Moyer, Margaret Y, Ballinger, William E, Beebe, David A, Berger, Richard, Coutcher, James B, Day, Wesley W, Li, Jiancheng, Mylari, Banavara L, Oates, Peter J, Weekly, R. Matthew

Volltext

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats von Cameron, Kimberly O., Lefker, Bruce A., Chu-Moyer, Margaret Y., Crawford, David T., Jardine, Paul DaSilva, DeNinno, Shari L., Gilbert, Sandra, Grasser, William A., Ke, HuaZhu, Lu, Bihong, Owen, Thomas A., Paralkar, Vishwas M., Qi, Hong, Scott, Dennis O., Thompson, David D., Tjoa, Christina M., Zawistoski, Michael P.

Volltext

An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid von Gmeiner, Peter, Feldman, Paul L, Chu-Moyer, Margaret Y, Rapoport, Henry

Volltext

Antiviral target compound profile for pandemic preparedness von Demarest, James F, Draghia-Akli, Ruxandra, Cihlar, Tomas, Bradley, Kenneth, Young, John A T, Chandra, Richa, Vaidyanathan, Sujata, Chu-Moyer, Margaret, Lynch, Christopher L, Campbell, Andrew, Saikatendu, Kumar Singh, Bilello, John P, Murata, Yoshihiko, van Loock, Marnix, Hurt, Aeron C, Tellinghuisen, Timothy, Ruggiero, Lee, Mackman, Richard, Hill, Nina M, Pottage, Jr, John C

Volltext

The total synthesis of indolizomycin von Kim, Guncheol, Chu-Moyer, Margaret Y, Danishefsky, Samuel J, Schulte, Gayle K

Volltext

SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711 von Chu-Moyer, Margaret Y., Ballinger, William E., Beebe, David A., Coutcher, James B., Day, Wesley W., Li, Jiancheng, Oates, Peter J., Weekly, R.Matthew

Volltext

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Viv... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

Volltext

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities von Weiss, Matthew M, Dineen, Thomas A, Marx, Isaac E, Altmann, Steven, Boezio, Alessandro, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Feric Bojic, Elma, Foti, Robert S, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Huang, Hongbing, Huang, Liyue, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, Ligutti, Joseph, La, Daniel S, Lin, Min-Hwa Jasmine, Liu, Dong, Moyer, Bryan D, Nguyen, Hanh N, Peterson, Emily A, Rose, Paul E, Taborn, Kristin, Youngblood, Beth D, Yu, Violeta, Fremeau, Robert T

Volltext

Total Synthesis of (.+-.)-Myrocin C von Chu-Moyer, Margaret Y, Danishefsky, Samuel J, Schulte, Gayle K

Volltext

A Remarkable Glycosidation Reaction: The Total Synthesis of Calicheamicin .gamma.1I von Hitchcock, Stephen A, Chu-Moyer, Margaret Y, Boyer, Serge H, Olson, Steven H, Danishefsky, Samuel J

Volltext

Preparation of the Four Regioisomeric 2-(Methylthio)oxazolopyridines: Useful Synthons for Elaboration to 2-(Amino substituted)oxazolopyridines von Chu-Moyer, Margaret Y, Berger, Richard

Volltext

The total synthesis of dl-indolizomycin von Kim, Guncheol, Chu-Moyer, Margaret Y, Danishefsky, Samuel J

Volltext

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition von Boezio, Alessandro A., Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W., DiMauro, Erin F., Foti, Robert S., Fremeau, Robert T., Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F., Gunaydin, Hakan, Huang, Hongbing, La, Daniel S., Ligutti, Joseph, Moyer, Bryan D., Peterson, Emily A., Yu, Violeta, Weiss, Matthew M.

Volltext

A remarkable cyclopropanation: the total synthesis of myrocin C von Chu-Moyer, Margaret Y, Danishefsky, Samuel J

Volltext

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition von Boezio, Alessandro A, Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W, DiMauro, Erin F, Foti, Robert S, Fremeau, Jr, Robert T, Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F, Gunaydin, Hakan, Huang, Hongbing, La, Daniel S, Ligutti, Joseph, Moyer, Bryan D, Peterson, Emily A, Yu, Violeta, Weiss, Matthew M

Volltext

A Convergent Total Synthesis of Calicheamicin γ 1I von Hitchcock, Stephen A., Boyer, Serge H., Chu-Moyer, Margaret Y., Olson, Steven H., Danishefsky, Samuel J.

Volltext