Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development von Ding, Qingjie, Zhang, Zhuming, Liu, Jin-Jun, Jiang, Nan, Zhang, Jing, Ross, Tina M, Chu, Xin-Jie, Bartkovitz, David, Podlaski, Frank, Janson, Cheryl, Tovar, Christian, Filipovic, Zoran M, Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir T, Graves, Bradford

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The Tuberculosis Drug Accelerator at year 10: what have we learned? von Aldridge, Bree B., Barros-Aguirre, David, Barry, Clifton E., Bates, Robert H., Berthel, Steven J., Boshoff, Helena I., Chibale, Kelly, Chu, Xin-Jie, Cooper, Christopher B., Dartois, Véronique, Duncan, Ken, Fotouhi, Nader, Gusovsky, Fabian, Hipskind, Philip A., Kempf, Dale J., Lelièvre, Joël, Lenaerts, Anne J., McNamara, Case W., Mizrahi, Valerie, Nathan, Carl, Olsen, David B., Parish, Tanya, Petrassi, H. Michael, Pym, Alexander, Rhee, Kyu Y., Robertson, Gregory T., Rock, Jeremy Michael, Rubin, Eric J., Russell, Betsy, Russell, David G., Sacchettini, James C., Schnappinger, Dirk, Schrimpf, Michael, Upton, Anna M., Warner, Peter, Wyatt, Paul Graham, Yuan, Ying

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development von Zhang, Zhuming, Chu, Xin-Jie, Liu, Jin-Jun, Ding, Qingjie, Zhang, Jing, Bartkovitz, David, Jiang, Nan, Karnachi, Prabha, So, Sung-Sau, Tovar, Christian, Filipovic, Zoran M, Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford

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Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis von Mo, Cheng, Xu, Xiaoqing, Zhang, Pan, Peng, Yihong, Zhao, Xinpeng, Chen, Shijia, Guo, Fang, Xiong, Yating, Chu, Xin-Jie, Xu, Xiaodong

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Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase von Lu, Gaofei, Zhang, Xi, Zheng, Weinan, Sun, Jialei, Hua, Lan, Xu, Lan, Chu, Xin-Jie, Ding, Sheng, Xiong, Wen

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In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials von DePinto, Wanda, Chu, Xin-Jie, Yin, Xuefeng, Smith, Melissa, Packman, Kathryn, Goelzer, Petra, Lovey, Allen, Chen, Yingsi, Qian, Hong, Hamid, Rachid, Xiang, Qing, Tovar, Christian, Blain, Roger, Nevins, Tom, Higgins, Brian, Luistro, Leopoldo, Kolinsky, Kenneth, Felix, Bernardo, Hussain, Sazzad, Heimbrook, David

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Total Synthesis of Vancomycin-Part 1: Design and Development of Methodology von Nicolaou, K. C., Li, Hui, Boddy, Christopher N. C., Ramanjulu, Joshi M., Yue, Tai-Yuen, Natarajan, Swaminathan, Chu, Xin-Jie, Bräse, Stefan, Rübsam, Frank

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Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy von Zhang, Zhuming, Ding, Qingjie, Liu, Jin-Jun, Zhang, Jing, Jiang, Nan, Chu, Xin-Jie, Bartkovitz, David, Luk, Kin-Chun, Janson, Cheryl, Tovar, Christian, Filipovic, Zoran M., Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir T., Graves, Bradford

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Experimental Study on Emergency Reclaiming of Offshore Underwater Leakage Oil von Gao, Hui, Xu, Song Sen, Chu, Xin Jie

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Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System von Nicolaou, K. C., Bunnage, Mark E., McGarry, Daniel G., Shi, Shuhao, Somers, Patricia K., Wallace, Paul A., Chu, Xin-Jie, Agrios, Konstantinos A., Gunzner, Janet L., Yang, Zhen

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Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors von Bungard, Christopher J, Williams, Peter D, Schulz, Jurgen, Wiscount, Catherine M, Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J, Su, Hua-Poo, Bennett, David J, Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P, Keertikar, Kartik, Morriello, Gregori J, Stamford, Andrew W, Waddell, Sherman T, Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L, Bahnck-Teets, Carolyn, Carroll, Steven S, Fay, John F, Min, Xu, Morris, William, Ballard, Jeanine E, Miller, Michael D, McCauley, John A

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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives von Gilbert, Eric J., Brunskill, Andrew, Cai, Jiaqiang, Cai, Yaxian, Chu, Xin-Jie, Dai, Xing, Hao, Jinsong, Kuethe, Jeffrey T., Lai, Zhong, Liu, Hong, Mu, Cuizhi, Qi, Yan, Scott, Jack D., Taoka, Brandon, Truong, Quang, Walsh, Shawn P., Wu, Wen-Lian, Cumming, Jared N.

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Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibit... von Chu, Xin-Jie, DePinto, Wanda, Bartkovitz, David, So, Sung-Sau, Vu, Binh T, Packman, Kathryn, Lukacs, Christine, Ding, Qingjie, Jiang, Nan, Wang, Ka, Goelzer, Petra, Yin, Xuefeng, Smith, Melissa A, Higgins, Brian X, Chen, Yingsi, Xiang, Qing, Moliterni, John, Kaplan, Gerald, Graves, Bradford, Lovey, Allen, Fotouhi, Nader

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Identification of novel, potent and selective inhibitors of Polo-like kinase 1 von Chen, Shaoqing, Bartkovitz, David, Cai, Jianping, Chen, Yi, Chen, Zhi, Chu, Xin-Jie, Le, Kang, Le, Nam T., Luk, Kin-Chun, Mischke, Steve, Naderi-Oboodi, Goli, Boylan, John F., Nevins, Tom, Qing, Weiguo, Chen, Yingsi, Wovkulich, Peter M.

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A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides von Sun, Hongmao, Greeley, David N., Chu, Xin-Jie, Cheung, Adrian, Danho, Waleed, Swistok, Joseph, Wang, Yao, Zhao, Chunlin, Chen, Li, Fry, David C.

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Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides von Chu, Xin-Jie, Bartkovitz, David, Danho, Waleed, Swistok, Joseph, Cheung, Adrian Wai-Hing, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Qi, Lida, Chen, Li, Yagaloff, Keith

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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution von CHEUNG, Adrian Wai-Hing, DANHO, Waleed, YAGALOFF, Keith, SWISTOK, Joseph, LIDA QI, KURYLKO, Grazyna, ROWAN, Karen, YEON, Mitch, FRANCO, Lucia, CHU, Xin-Jie, LI CHEN

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New Technology for the Synthesis of Vancomycin-Type Biaryl Ring Systems von Nicolaou, K. C., Chu, Xin-Jie, Ramanjulu, Joshi M., Natarajan, Swaminathan, Bräse, Stefan, Rübsam, Frank, Boddy, Christopher N. C.

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WED-510 - Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis von Xu, Michael, Chen, Shijia, Guo, Fang, Liu, Que, Liu, Yongheng, Mo, Cheng, Peng, Yihong, Xiong, Yating, Zhai, Peibin, Zhang, Pan, Zhao, Xinpeng, Zhou, Xin, Chu, Xin-Jie

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Preclinical characterization of HPG7233, a potent, liver-target and highly selective thyroid hormone receptor beta agonist for non-alcoholic steatohepatitis von Xu, Michael, Chen, Shijia, Guo, Fang, Liu, Que, Liu, Yongheng, Mo, Cheng, Peng, Yihong, Xiong, Yating, Zhai, Peibin, Zhang, Pan, Zhao, Xinpeng, Zhou, Xin, Chu, Xin-Jie

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