Total Synthesis of Aigialomycin D:  Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations von Chrovian, Christa C, Knapp-Reed, Beth, Montgomery, John

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Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions von Chrovian, Christa C, Montgomery, John

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A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]­triazolo[4,5‑c]­pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Anta... von Chrovian, Christa C, Soyode-Johnson, Akinola, Peterson, Alexander A, Gelin, Christine F, Deng, Xiaohu, Dvorak, Curt A, Carruthers, Nicholas I, Lord, Brian, Fraser, Ian, Aluisio, Leah, Coe, Kevin J, Scott, Brian, Koudriakova, Tatiana, Schoetens, Freddy, Sepassi, Kia, Gallacher, David J, Bhattacharya, Anindya, Letavic, Michael A

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Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators von Gelin, Christine F., Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L., Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J., Wang, Kai, Alcázar, Jesus, Chrovian, Christa C., Dvorak, Curt A., Carruthers, Nicholas I., Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A.

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Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators von Gelin, Christine F, Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L, Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J, Wang, Kai, Alcázar, Jesus, Chrovian, Christa C, Dvorak, Curt A, Carruthers, Nicholas I, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treat... von Chrovian, Christa C, Soyode-Johnson, Akinola, Stenne, Brice, Pippel, Daniel J, Schoellerman, Jeffrey, Lord, Brian, Needham, Alexandra S, Xia, Chungfang, Coe, Kevin J, Sepassi, Kia, Schoetens, Freddy, Scott, Brian, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase von Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillán, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.

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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists von Rudolph, Dale A., Alcazar, Jesus, Ameriks, Michael K., Anton, Ana Belen, Ao, Hong, Bonaventure, Pascal, Carruthers, Nicholas I., Chrovian, Christa C., De Angelis, Meri, Lord, Brian, Rech, Jason C., Wang, Qi, Bhattacharya, Anindya, Andres, Jose Ignacio, Letavic, Michael A.

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1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators von Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators von Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain von Chrovian, Christa C, Soyode-Johnson, Akinola, Ao, Hong, Bacani, Genesis M, Carruthers, Nicholas I, Lord, Brian, Nguyen, Leslie, Rech, Jason C, Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A

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Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase von Eccles, Wendy, Blevitt, Jonathan M, Booker, Jamila N, Chrovian, Christa C, Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M, Grice, Cheryl A, Herman, Krystal, Karlsson, Lars, Kearney, Aaron M, Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P, Santillán, Alejandro, Savall, Brad, Tanis, Virginia M, Xue, Xiaohua, Young, Arlene L

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Azabenzthiazole inhibitors of leukotriene A4 hydrolase von Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillán, Alejandro, Wiener, John J.M., Xue, Xiaohua, Young, Arlene L.

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A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1 H -[1,2,3]triazolo[4,5- c ]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 An... von Chrovian, Christa C., Soyode-Johnson, Akinola, Peterson, Alexander A., Gelin, Christine F., Deng, Xiaohu, Dvorak, Curt A., Carruthers, Nicholas I., Lord, Brian, Fraser, Ian, Aluisio, Leah, Coe, Kevin J., Scott, Brian, Koudriakova, Tatiana, Schoetens, Freddy, Sepassi, Kia, Gallacher, David J., Bhattacharya, Anindya, Letavic, Michael A.

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4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b von LETAVIC, Michael A, CHROVIAN, Christa C, SOYODE-JOHNSON, Akinola, WALL, Jessica L, RECH, Jason C

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SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS von RECH, JASON C, WALL, JESSICA L, LETAVIC, MICHAEL A, CHROVIAN, CHRISTA C, SOYODE-JOHNSON, AKINOLA

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P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES von RECH, JASON C, ANDRES GIL, JOSE IGNACIO, LETAVIC, MICHAEL A, RUDOLPH, DALE A, SOYODE-JOHNSON, AKINOLA, CHROVIAN, CHRISTA C

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SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS von Wall, Jessica L, Rech, Jason C, Stenne, Brice M, Letavic, Michael A, Rudolph, Dale A, Soyode-Johnson, Akinola, Chrovian, Christa C

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Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators von Wall, Jessica L, Rech, Jason C, Stenne, Brice M, Letavic, Michael A, Rudolph, Dale A, Soyode-Johnson, Akinola, Chrovian, Christa C

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P2X7 MODULATORS von LETAVIC, Michael A, ANDRES GIL, Jose Ignacio, RUDOLPH, Dale A, CHROVIAN, Christa C, SOYODE-JOHNSON, Akinola, RECH, Jason C

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