Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates von Deng, James Z, Paone, Daniel V, Ginnetti, Anthony T, Kurihara, Hideki, Dreher, Spencer D, Weissman, Steven A, Stauffer, Shaun R, Burgey, Christopher S

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Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose von Ballard, Jeanine E, Pall, Parul S, Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A, Zhou, Xiaoping, Jochnowitz, Nina, Kraus, Richard L, Klein, Rebecca M, Henze, Darrell A, Houghton, Andrea K, Burgey, Christopher S, Gibson, Christopher, Struyk, Arie

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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trif... von Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M

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Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy von Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.

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Expanding the scope of the Cu assisted Suzuki–Miyaura reaction von Crowley, Brendan M., Potteiger, Craig M., Deng, James Z., Prier, Christopher K., Paone, Daniel V., Burgey, Christopher S.

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Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor von Moore, Eric, Fraley, Mark E., Bell, Ian M., Burgey, Christopher S., White, Rebecca B., Li, Chi-Chung, Regan, Christopher P., Danziger, Andrew, Michener, Maria Stranieri, Hostetler, Eric, Banerjee, Pradeep, Salvatore, Christopher

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Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist von Moore, Eric, Bell, Ian M, Fraley, Mark E, Burgey, Christopher S, White, Rebecca B, Li, Chi-Chung, Regan, Christopher P, Danziger, Andrew, McGaraughty, Steve P, Naseri Kouzehgarani, Ghazal, Salvatore, Christopher, Banerjee, Pradeep

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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis von Ginnetti, Anthony T., Paone, Daniel V., Nanda, Kausik K., Li, Jing, Busuek, Marina, Johnson, Scott A., Lu, Jun, Soisson, Stephen M., Robinson, Ronald, Fisher, John, Webber, Andrea, Wesolowski, Gregg, Ma, Bennett, Duong, Le, Carroll, Steven, Burgey, Christopher S., Stachel, Shawn J.

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Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate von Ballard, Jeanine E., Pall, Parul, Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Kraus, Richard, Li, Yuxing, Henze, Darrell, Houghton, Andrea, Burgey, Christopher S., Gibson, Christopher

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Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines von Burgey, Christopher S, Robinson, Kyle A, Lyle, Terry A, Sanderson, Philip E. J, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Lyle, Elizabeth A, Williams, Peter D, Coburn, Craig A, Dorsey, Bruce D, Barrow, James C, Stranieri, Maria T, Holahan, Marie A, Sitko, Gary R, Cook, Jacquelynn J, McMasters, Daniel R, McDonough, Colleen M, Sanders, William M, Wallace, Audrey A, Clayton, Franklin C, Bohn, Dennis, Leonard, Yvonne M, Detwiler, Theodore J, Lynch, Joseph J, Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J, Shafer, Jules A, Vacca, Joseph P

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Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists von Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.

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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain von Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M

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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na v 1.7 for the Treatment of Pain von Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo' Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M

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Identification of second-generation P2X3 antagonists for treatment of pain von Ginnetti, Anthony T., Paone, Daniel V., Stauffer, Shaun R., Potteiger, Craig M., Shaw, Anthony W., Deng, James, Mulhearn, James J., Nguyen, Diem N., Segerdell, Carolyn, Anquandah, Juliana, Calamari, Amy, Cheng, Gong, Leitl, Michael D., Liang, Annie, Moore, Eric, Panigel, Jacqueline, Urban, Mark, Wang, Jixin, Fillgrove, Kerry, Tang, Cuyue, Cook, Sean, Kane, Stefanie, Salvatore, Christopher A., Graham, Samuel L., Burgey, Christopher S.

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Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile von Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S

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Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile von Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, 3rd, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S

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Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine von Crowley, Brendan M., Stump, Craig A., Nguyen, Diem N., Potteiger, Craig M., McWherter, Melody A., Paone, Daniel V., Quigley, Amy G., Bruno, Joseph G., Cui, Dan, Culberson, J. Christopher, Danziger, Andrew, Fandozzi, Christine, Gauvreau, Danny, Kemmerer, Amanda L., Menzel, Karsten, Moore, Eric L., Mosser, Scott D., Reddy, Vijay, White, Rebecca B., Salvatore, Christopher A., Kane, Stefanie A., Bell, Ian M., Selnick, Harold G., Fraley, Mark E., Burgey, Christopher S.

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C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of the Catalytic Enantioselective Aldol Additions of Enolsilanes to Pyruvate Esters von EVANS, David A., BURGEY, Christopher S., KOZLOWSKI, Marisa C., TREGAY, Steven W.

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C 2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of the Catalytic Enantioselective Aldol Additions of Enolsilanes to Pyruvate Esters von Evans, David A, Burgey, Christopher S, Kozlowski, Marisa C, Tregay, Steven W

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C 2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of Catalytic Enantioselective Aldol Additions of Enolsilanes to (Benzyloxy)acetaldehyde von Evans, David A, Kozlowski, Marisa C, Murry, Jerry A, Burgey, Christopher S, Campos, Kevin R, Connell, Brian T, Staples, Richard J

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