JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid t... von Manthey, Carl L, Johnson, Dana L, Illig, Carl R, Tuman, Robert W, Zhou, Zhao, Baker, Judith F, Chaikin, Margery A, Donatelli, Robert R, Franks, Carol F, Zeng, Lee, Crysler, Carl, Chen, Yanmin, Yurkow, Edward J, Boczon, Lisa, Meegalla, Sanath K, Wilson, Kenneth J, Wall, Mark J, Chen, Jinsheng, Ballentine, Shelley K, Ott, Heidi, Baumann, Christian, Lawrence, Danielle, Tomczuk, Bruce E, Molloy, Christopher J

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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo von Koblish, Holly K, Zhao, Shuyuan, Franks, Carol F, Donatelli, Robert R, Tominovich, Rose M, LaFrance, Louis V, Leonard, Kristi A, Gushue, Joan M, Parks, Daniel J, Calvo, Raul R, Milkiewicz, Karen L, Marugán, Juan José, Raboisson, Pierre, Cummings, Maxwell D, Grasberger, Bruce L, Johnson, Dana L, Lu, Tianbao, Molloy, Christopher J, Maroney, Anna C

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Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells von Grasberger, Bruce L, Lu, Tianbao, Schubert, Carsten, Parks, Daniel J, Carver, Theodore E, Koblish, Holly K, Cummings, Maxwell D, LaFrance, Louis V, Milkiewicz, Karen L, Calvo, Raul R, Maguire, Diane, Lattanze, Jennifer, Franks, Carol F, Zhao, Shuyuan, Ramachandren, Kannan, Bylebyl, Gwendolyn R, Zhang, Marie, Manthey, Carl L, Petrella, Eugene C, Pantoliano, Michael W, Deckman, Ingrid C, Spurlino, John C, Maroney, Anna C, Tomczuk, Bruce E, Molloy, Christopher J, Bone, Roger F

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(... von Illig, Carl R, Manthey, Carl L, Wall, Mark J, Meegalla, Sanath K, Chen, Jinsheng, Wilson, Kenneth J, Ballentine, Shelley K, DesJarlais, Renee L, Schubert, Carsten, Crysler, Carl S, Chen, Yanmin, Molloy, Christopher J, Chaikin, Margery A, Donatelli, Robert R, Yurkow, Edward, Zhou, Zhao, Player, Mark R, Tomczuk, Bruce E

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Pharmacokinetic and Pharmacodynamic Modeling of Pegylated Thrombopoietin Mimetic Peptide (PEG-TPOm) After Single Intravenous Dose Administration in Healthy Subjects von Samtani, Mahesh N., Perez-Ruixo, Juan Jose, Brown, Kathryn H., Cerneus, Dirk, Molloy, Christopher J.

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Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors von Illig, Carl R., Manthey, Carl L., Meegalla, Sanath K., Wall, Mark J., Chen, Jinsheng, Wilson, Kenneth J., DesJarlais, Renee L., Ballentine, Shelley K., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Donatelli, Robert R., Yurkow, Edward, Zhou, Zhao, Player, Mark R., Tomczuk, Bruce E.

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The discovery of novel cyclohexylamide CCR2 antagonists von Lanter, James C., Markotan, Thomas P., Zhang, Xuqing, Subasinghe, Nalin, Kang, Fu-An, Hou, Cuifen, Singer, Monica, Opas, Evan, McKenney, Sandra, Crysler, Carl, Johnson, Dana, Molloy, Christopher J., Sui, Zhihua

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Discovery of novel FMS kinase inhibitors as anti-inflammatory agents von Illig, Carl R., Chen, Jinsheng, Wall, Mark J., Wilson, Kenneth J., Ballentine, Shelley K., Rudolph, M. Jonathan, DesJarlais, Renee L., Chen, Yanmin, Schubert, Carsten, Petrounia, Ioanna, Crysler, Carl S., Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Meegalla, Sanath K.

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Structure-based optimization of a potent class of arylamide FMS inhibitors von Meegalla, Sanath K., Wall, Mark J., Chen, Jinsheng, Wilson, Kenneth J., Ballentine, Shelley K., DesJarlais, Renee L., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Illig, Carl R.

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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s von Subasinghe, Nalin L., Khalil, Ehab, Travins, Jeremy M., Ali, Farah, Ballentine, Shelley K., Hufnagel, Heather R., Pan, Wenxi, Leonard, Kristi, Bone, Roger F., Soll, Richard M., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Kolpak, Michael X., Diloreto, Karen A., Eisennagel, Stephen H., Huebert, Norman D., Molloy, Christopher J., Tomczuk, Bruce E., Gaul, Michael D.

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Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors von WILSON, Kenneth J, ILLIG, Carl R, ZHANG, Marie, LEWANDOWSKI, Frank A, ZHAO ZHOU, SHARP, Celia, MAGUIRE, Diane, GRASBERGER, Bruce, DESJARLAIS, Renee L, SPURLINO, John, SUBASINGHE, Nalin, HOFFMAN, James B, RUDOLPH, M. Jonathan, SOLL, Richard, MOLLOY, Christopher J, BONE, Roger, GREEN, David, RANDALL, Troy

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Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors von Wilson, Kenneth J., Illig, Carl R., Chen, Jinsheng, Wall, Mark J., Ballentine, Shelley K., DesJarlais, Renee L., Chen, Yanmin, Schubert, Carsten, Donatelli, Robert, Petrounia, Ioanna, Crysler, Carl S., Molloy, Christopher J., Chaikin, Margery A., Manthey, Carl L., Player, Mark R., Tomczuk, Bruce E., Meegalla, Sanath K.

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Orally Active Endothelin Receptor Antagonist BMS-182874 Suppresses Neointimal Development in Balloon-Injured Rat Carotid Arteries von Ferrer, Patricia, Valentine, Maria, Jenkins-West, Tonya, Weber, Helen, Goller, Nancy L, Durham, Stephen K, Molloy, Christopher J, Moreland, Suzanne

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PDGF induction of tyrosine phosphorylation of GTPase activating protein von Molloy, Christopher J., Bottaro, Donald P., Fleming, Timothy P., Marshall, Mark S., Gibbs, Jackson B., Aaronson, Stuart A.

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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s von Travins, Jeremy M., Ali, Farah, Huang, Hui, Ballentine, Shelley K., Khalil, Ehab, Hufnagel, Heather R., Pan, Wenxi, Gushue, Joan, Leonard, Kristi, Bone, Roger F., Soll, Richard M., DesJarlais, Renee L., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Cummings, Maxwell D., Huebert, Norman, Molloy, Christopher J., Gaul, Michael, Tomczuk, Bruce E., Subasinghe, Nalin L.

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Epiregulin Is a Potent Vascular Smooth Muscle Cell-Derived Mitogen Induced by Angiotensin II, Endothelin-1, and Thrombin von Taylor, David S., Cheng, Xinbo, Pawlowski, John E., Wallace, Alison R., Ferrer, Patricia, Molloy, Christopher J.

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A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s von Subasinghe, Nalin L., Travins, Jeremy M., Ali, Farah, Huang, Hui, Ballentine, Shelley K., Marugán, Juan José, Khalil, Ehab, Hufnagel, Heather R., Bone, Roger F., DesJarlais, Renee L., Crysler, Carl S., Ninan, Nisha, Cummings, Maxwell D., Molloy, Christopher J., Tomczuk, Bruce E.

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Structure-Based design, synthesis and sAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors von Subasinghe, Nalin L., Illig, Carl, Hoffman, James, Rudolph, M.Jonathan, Wilson, Kenneth J., Soll, Richard, Randle, Troy, Green, David, Lewandowski, Frank, Zhang, Marie, Bone, Roger, Spurlino, John, DesJarlais, Renee, Deckman, Ingrid, Molloy, Christopher J., Manthey, Carl, Zhou, Zhau, Sharp, Celia, Maguire, Diane, Crysler, Carl, Grasberger, Bruce

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano- N -[2-(1-cyclohexen-1-yl)-4-[1-... von Illig, Carl R., Manthey, Carl L., Wall, Mark J., Meegalla, Sanath K., Chen, Jinsheng, Wilson, Kenneth J., Ballentine, Shelley K., DesJarlais, Renee L., Schubert, Carsten, Crysler, Carl S., Chen, Yanmin, Molloy, Christopher J., Chaikin, Margery A., Donatelli, Robert R., Yurkow, Edward, Zhou, Zhao, Player, Mark R., Tomczuk, Bruce E.

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Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma von WALKER, C, BERMUDEZ, E, STEWART, W, BGONNER, J, MOLLOY, C. J, EVERITT, J

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