TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells von Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic

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Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents von Asshoff, Malte, Petzer, Verena, Warr, Matthew R., Haschka, David, Tymoszuk, Piotr, Demetz, Egon, Seifert, Markus, Posch, Wilfried, Nairz, Manfred, Maciejewski, Pat, Fowles, Peter, Burns, Christopher J., Smith, Gregg, Wagner, Kay-Uwe, Weiss, Guenter, Whitney, J.Andrew, Theurl, Igor

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Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer von Vaillant, François, Merino, Delphine, Lee, Lily, Breslin, Kelsey, Pal, Bhupinder, Ritchie, Matthew E., Smyth, Gordon K., Christie, Michael, Phillipson, Louisa J., Burns, Christopher J., Mann, G. Bruce, Visvader, Jane E., Lindeman, Geoffrey J.

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CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms von Tyner, Jeffrey W., Bumm, Thomas G., Deininger, Jutta, Wood, Lisa, Aichberger, Karl J., Loriaux, Marc M., Druker, Brian J., Burns, Christopher J., Fantino, Emmanuelle, Deininger, Michael W.

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Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1 von Patel, Onisha, Dai, Weiwen, Mentzel, Mareike, Griffin, Michael D.W., Serindoux, Juliette, Gay, Yoann, Fischer, Stefanie, Sterle, Shoukat, Kropp, Ashleigh, Burns, Christopher J., Ernst, Matthias, Buchert, Michael, Lucet, Isabelle S.

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Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden von Abubaker, Khalid, Luwor, Rodney B, Zhu, Hongjian, McNally, Orla, Quinn, Michael A, Burns, Christopher J, Thompson, Erik W, Findlay, Jock K, Ahmed, Nuzhat

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Therapeutic Effects of a TANK‐Binding Kinase 1 Inhibitor in Germinal Center–Driven Collagen‐Induced Arthritis von Louis, Cynthia, Ngo, Devi, D'Silva, Damian B., Hansen, Jacinta, Phillipson, Louisa, Jousset, Helene, Novello, Patrizia, Segal, David, Lawlor, Kate E., Burns, Christopher J., Wicks, Ian P.

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A constricted opening in Kir channels does not impede potassium conduction von Black, Katrina A., He, Sitong, Jin, Ruitao, Miller, David M., Bolla, Jani R., Clarke, Oliver B., Johnson, Paul, Windley, Monique, Burns, Christopher J., Hill, Adam P., Laver, Derek, Robinson, Carol V., Smith, Brian J., Gulbis, Jacqueline M.

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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor von Lucet, Isabelle S., Fantino, Emmanuelle, Styles, Michelle, Bamert, Rebecca, Patel, Onisha, Broughton, Sophie E., Walter, Mark, Burns, Christopher J., Treutlein, Herbert, Wilks, Andrew F., Rossjohn, Jamie

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Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma von Weeden, Clare E, Holik, Aliaksei Z, Young, Richard J, Ma, Stephen B, Garnier, Jean-Marc, Fox, Stephen B, Antippa, Phillip, Irving, Louis B, Steinfort, Daniel P, Wright, Gavin M, Russell, Prudence A, Ritchie, Matthew E, Burns, Christopher J, Solomon, Benjamin, Asselin-Labat, Marie-Liesse

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HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo von Lilja, Andrew, Weeden, Clare E, McArthur, Kate, Nguyen, Thao, Donald, Alastair, Wong, Zi Xin, Dousha, Lovisa, Bozinovski, Steve, Vlahos, Ross, Burns, Christopher J, Asselin-Labat, Marie-Liesse, Anderson, Gary P

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Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages von Irvine, Katharine M., Andrews, Melanie R., Fernandez‐Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A., Sweet, Matthew J.

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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections von Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W, Hamrick, Jodie C, Daigle, Denis M, Cusick, Susan M, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J, Pevear, Daniel C, Xerri, Luigi, Burns, Christopher J

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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa von Hamrick, Jodie C, Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L, Six, David A, Chatwin, Cassandra L, John, Kaitlyn J, Vernacchio, Salvador F, Cusick, Susan M, Trout, Robert E L, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W, Moeck, Greg, Xerri, Luigi, Burns, Christopher J, Pevear, Daniel C, Daigle, Denis M

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Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors von Sharp, Phillip P, Garnier, Jean-Marc, Hatfaludi, Tamas, Xu, Zhen, Segal, David, Jarman, Kate E, Jousset, Hélène, Garnham, Alexandra, Feutrill, John T, Cuzzupe, Anthony, Hall, Peter, Taylor, Scott, Walkley, Carl R, Tyler, Dean, Dawson, Mark A, Czabotar, Peter, Wilks, Andrew F, Glaser, Stefan, Huang, David C. S, Burns, Christopher J

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Chromatin targeting: A BET inhibitor workaround von Burns, Christopher J

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Prevalence and impact of late defecation in the critically ill, thermally injured adult patient von Trexler, Scott T, Lundy, Jonathan B, Chung, Kevin K, Nitzschke, Stephanie L, Burns, Christopher J, Shields, Beth A, Cancio, Leopoldo C

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The Use of JAK-Specific Inhibitors as Chemical Biology Tools von Burns, Christopher J., Segal, David, Wilks, Andrew F.

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BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells von Baker, Emma K, Taylor, Scott, Gupte, Ankita, Sharp, Phillip P, Walia, Mannu, Walsh, Nicole C, Zannettino, Andrew CW, Chalk, Alistair M, Burns, Christopher J, Walkley, Carl R

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Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β‑Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes von Trout, Robert E, Zulli, Allison, Mesaros, Eugen, Jackson, Randy W, Boyd, Steven, Liu, Bin, Hamrick, Jodie, Daigle, Denis, Chatwin, Cassandra L, John, Kaitlyn, McLaughlin, Lisa, Cusick, Susan M, Weiss, William J, Pulse, Mark E, Pevear, Daniel C, Moeck, Greg, Xerri, Luigi, Burns, Christopher J

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