Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor von Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J

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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor von Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin

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Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems von Zhang, Wei, Lu, Yimin, Chen, Christine Hiu-Tung, Curran, Dennis P., Geib, Steven

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Fluorous synthesis of biaryl-substituted proline analogs by 1,3-dipolar cycloaddition and Suzuki coupling reactions von Zhang, Wei, Chen, Christine Hiu-Tung

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Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis von Zhang, Wei, Curran, Dennis P, Chen, Christine Hiu-Tung

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A traceless perfluorooctylsulfonyl tag for deoxygenation of phenols under microwave irradiation von Zhang, Wei, Nagashima, Tadamichi, Lu, Yimin, Chen, Christine Hiu-Tung

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“Addition” and “Subtraction”: Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors von Chen, Xin, Giraldes, John, Sprague, Elizabeth R, Shakya, Subarna, Chen, Zhuoliang, Wang, Yaping, Joud, Carol, Mathieu, Simon, Chen, Christine Hiu-Tung, Straub, Christopher, Duca, Jose, Hurov, Kristen, Yuan, Yanqiu, Shao, Wenlin, Touré, B. Barry

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Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides von Zhang, Wei, Lu, Yimin, Chen, Christine Hiu-Tung

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A Highly Efficient Microwave-Assisted Suzuki Coupling Reaction of Aryl Perfluorooctylsulfonates with Boronic Acids von Zhang, Wei, Chen, Christine Hiu-Tung, Lu, Yimin, Nagashima, Tadamichi

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Solution-Phase Preparation of a 560-Compound Library of Individual Pure Mappicine Analogues by Fluorous Mixture Synthesis von Zhang, Wei, Luo, Zhiyong, Chen, Christine Hiu-Tung, Curran, Dennis P

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Fluorous electrophilic scavengers for solution-phase parallel synthesis von Zhang, Wei, Chen, Christine Hiu-Tung, Nagashima, Tadamichi

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Transfer of Chirality in Radical Cyclizations. Cyclization of o-Haloacrylanilides to Oxindoles with Transfer of Axial Chirality to a Newly Formed Stereocenter von Curran, Dennis P, Liu, Weidong, Chen, Christine Hiu-Tung

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Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors von Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J, Feltell, Ruth, Giraldes, John, Hiscock, Steven D, Kim, Sunkyu, Kovats, Steven, Lagu, Bharat, Lewry, Kim, Loo, Alice, Lu, Yipin, Luzzio, Michael, Maniara, Wiesia, McMenamin, Rachel, Mortenson, Paul N, Benning, Rajdeep, O'Reilly, Marc, Rees, David C, Shen, Junqing, Smith, Troy, Wang, Yaping, Williams, Glyn, Woolford, Alison J.-A, Wrona, Wojciech, Xu, Mei, Yang, Fan, Howard, Steven

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FluoMar, a Fluorous Version of the Marshall Resin for Solution-Phase Library Synthesis von Chen, Christine Hiu-Tung, Zhang, Wei

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Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison von Chen, Christine Hiu-Tung, Zhang, Wei

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Cover Picture: Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems (Eur. J. Org. Chem. 9/2006) von Zhang, Wei, Lu, Yimin, Chen, Christine Hiu-Tung, Curran, Dennis P., Geib, Steven

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases von Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R., Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D., Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer von LaMarche, Matthew J, Acker, Michael, Argintaru, Andreea, Bauer, Daniel, Boisclair, Julie, Chan, Homan, Chen, Christine Hiu-Tung, Chen, Ying-Nan, Chen, Zhouliang, Deng, Zhan, Dore, Michael, Dunstan, David, Fan, Jianmei, Fekkes, Peter, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Fortin, Pascal D, Fridrich, Cary, Giraldes, John, Glick, Meir, Grunenfelder, Denise, Hao, Huia-Xiang, Hentemann, Martin, Ho, Samuel, Jouk, Andriana, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, Koenig, Robert, LaBonte, Laura R, Larrow, Jay, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Mathieu, Simon, Meyer, Matthew J, Mohseni, Morvarid, Ntaganda, Rukundo, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Reilly, John, Sarver, Patrick, Sellers, William R, Sendzik, Martin, Shultz, Michael D, Slisz, Joanna, Slocum, Kelly, Smith, Troy, Spence, Stanley, Stams, Travis, Straub, Christopher, Tamez, Victoriano, Toure, Bakary-Barry, Towler, Christopher, Wang, Ping, Wang, Hongyun, Williams, Sarah L, Yang, Fan, Yu, Bing, Zhang, Ji-Hu, Zhu, Suzanne

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Determination of the absolute configuration of 1,3,5,7-tetramethyl-1,3-dihydroindol-2-one by optical rotation computation von Kondru, Rama K., Hiu-Tung Chen, Christine, Curran, Dennis P., Beratan, David N., Wipf, Peter

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Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers von Acker, Michael G., Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, LaRochelle, Jonathan R., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhuoliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Feng, Fei, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, Bonte, Laura R. La, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Pu, Minying, Price, Edmund, Shakya, Subarna, Shultz, Michael D., Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Blacklow, Stephen C., Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.

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