In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections von LOCHER, Hans H, SEILER, Peter, KELLY, Ciaran P, KECK, Wolfgang, XINHUA CHEN, SCHROEDER, Susanne, PFAFF, Philippe, ENDERLIN, Michel, KLENK, Axel, FOURNIER, Elvire, HUBSCHWERLEN, Christian, RITZ, Daniel

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Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development von APFEL, Christian M, LOCHER, Hans, EVERS, Stefan, TAKACS, Béla, HUBSCHWERLEN, Christian, PIRSON, Wolfgang, PAGE, Malcolm G. P, KECKT, Wolfgang

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Design, Synthesis and Biological Evaluation of Oxazolidinone–Quinolone Hybrids von Hubschwerlen, Christian, Specklin, Jean-Luc, Sigwalt, Christine, Schroeder, Susanne, Locher, Hans H

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Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents von Apfel, Christian, Banner, David W, Bur, Daniel, Dietz, Michel, Hirata, Takahiro, Hubschwerlen, Christian, Locher, Hans, Page, Malcolm G. P, Pirson, Wolfgang, Rossé, Gérard, Specklin, Jean-Luc

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Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents von Panchaud, Philippe, Bruyère, Thierry, Blumstein, Anne-Catherine, Bur, Daniel, Chambovey, Alain, Ertel, Eric A, Gude, Markus, Hubschwerlen, Christian, Jacob, Loïc, Kimmerlin, Thierry, Pfeifer, Thomas, Prade, Lars, Seiler, Peter, Ritz, Daniel, Rueedi, Georg

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Discovery and Structure–Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection von Rueedi, Georg, Panchaud, Philippe, Friedli, Astrid, Specklin, Jean-Luc, Hubschwerlen, Christian, Blumstein, Anne-Catherine, Caspers, Patrick, Enderlin-Paput, Michel, Jacob, Loïc, Kohl, Christopher, Locher, Hans H., Pfaff, Philippe, Schmitt, Christine, Seiler, Peter, Ritz, Daniel

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Methanopyrus kandleri Glutamyl-tRNA Reductase von Moser, Jürgen, Lorenz, Stefan, Hubschwerlen, Christian, Rompf, Alexandra, Jahn, Dieter

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Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria von Surivet, Jean-Philippe, Panchaud, Philippe, Specklin, Jean-Luc, Diethelm, Stefan, Blumstein, Anne-Catherine, Gauvin, Jean-Christophe, Jacob, Loïc, Masse, Florence, Mathieu, Gaëlle, Mirre, Azely, Schmitt, Christine, Lange, Roland, Tidten-Luksch, Naomi, Gnerre, Carmela, Seeland, Swen, Herrmann, Charlyse, Seiler, Peter, Enderlin-Paput, Michel, Mac Sweeney, Aengus, Wicki, Micha, Hubschwerlen, Christian, Ritz, Daniel, Rueedi, Georg

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Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria von Surivet, Jean-Philippe, Zumbrunn, Cornelia, Bruyère, Thierry, Bur, Daniel, Kohl, Christopher, Locher, Hans H, Seiler, Peter, Ertel, Eric A, Hess, Patrick, Enderlin-Paput, Michel, Enderlin-Paput, Stéphanie, Gauvin, Jean-Christophe, Mirre, Azely, Hubschwerlen, Christian, Ritz, Daniel, Rueedi, Georg

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Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity von Surivet, Jean-Philippe, Zumbrunn, Cornelia, Rueedi, Georg, Hubschwerlen, Christian, Bur, Daniel, Bruyère, Thierry, Locher, Hans, Ritz, Daniel, Keck, Wolfgang, Seiler, Peter, Kohl, Christopher, Gauvin, Jean-Christophe, Mirre, Azely, Kaegi, Verena, Dos Santos, Marina, Gaertner, Mika, Delers, Jonathan, Enderlin-Paput, Michel, Boehme, Maria

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Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram Positive Activity and Improved Safety Profile von Surivet, Jean-Philippe, Zumbrunn, Cornelia, Rueedi, Georg, Bur, Daniel, Bruyère, Thierry, Locher, Hans, Ritz, Daniel, Seiler, Peter, Kohl, Christopher, Ertel, Eric A, Hess, Patrick, Gauvin, Jean-Christophe, Mirre, Azely, Kaegi, Verena, Dos Santos, Marina, Kraemer, Stéphanie, Gaertner, Mika, Delers, Jonathan, Enderlin-Paput, Michel, Weiss, Maria, Sube, Romain, Hadana, Hakim, Keck, Wolfgang, Hubschwerlen, Christian

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Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H von Gademann, Karl, Bethuel, Yann, Locher, Hans H, Hubschwerlen, Christian

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Peptide Deformylase as an Antibacterial Drug Target: Assays for Detection of Its Inhibition in Escherichia coli Cell Homogenates and Intact Cells von APFEL, Christian M, EVERS, Stefan, HUBSCHWERLEN, Christian, PIRSON, Wolfgang, PAGE, Malcolm G. P, KECKT, Wolfgang

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Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline von Blom, Judith F, Brütsch, Tobias, Barbaras, Damien, Bethuel, Yann, Locher, Hans H, Hubschwerlen, Christian, Gademann, Karl

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Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity von Surivet, Jean-Philippe, Lange, Roland, Hubschwerlen, Christian, Keck, Wolfgang, Specklin, Jean-Luc, Ritz, Daniel, Bur, Daniel, Locher, Hans, Seiler, Peter, Strasser, Daniel Stefan, Prade, Lars, Kohl, Christopher, Schmitt, Christine, Chapoux, Gaëlle, Ilhan, Eser, Ekambaram, Nadia, Athanasiou, Alcibiade, Knezevic, Andreja, Sabato, Daniela, Chambovey, Alain, Gaertner, Mika, Enderlin, Michel, Boehme, Maria, Sippel, Virginie, Wyss, Pierre

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Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Library Design and High-Throughput Synthesis and Screening von Wyss, Pierre C, Gerber, Paul, Hartman, Peter G, Hubschwerlen, Christian, Locher, Hans, Marty, Hans-Peter, Stahl, Martin

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Structure–activity relationship in the oxazolidinone–quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action von Hubschwerlen, Christian, Specklin, Jean-Luc, Baeschlin, Daniel K., Borer, Yves, Haefeli, Sascha, Sigwalt, Christine, Schroeder, Susanne, Locher, Hans H.

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A Convenient Synthesis of L-(S)-Glyceraldehyde Acetonide from L-Ascorbic Acid von Hubschwerlen, Christian

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2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-Dioxo-1,4-dihydro-2H-2λ6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as Potent and Selective Peptide Deformylase Inhibito... von Apfel, Christian, Banner, David W, Bur, Daniel, Dietz, Michel, Hubschwerlen, Christian, Locher, Hans, Marlin, Frédéric, Masciadri, Raffaello, Pirson, Wolfgang, Stalder, Henri

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Phenyl β-Methoxyacrylates:  A New Antimalarial Pharmacophore von Alzeer, Jawad, Chollet, Jacques, Heinze-Krauss, Ingrid, Hubschwerlen, Christian, Matile, Hugues, Ridley, Robert G

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