Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor von Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors von Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin

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The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis von Oser, Matthew G, Sabet, Amin H, Gao, Wenhua, Chakraborty, Abhishek A, Schinzel, Anna C, Jennings, Rebecca B, Fonseca, Raquel, Bonal, Dennis M, Booker, Matthew A, Flaifel, Abdallah, Novak, Jesse S, Christensen, Camilla L, Zhang, Hua, Herbert, Zachary T, Tolstorukov, Michael Y, Buss, Elizabeth J, Wong, Kwok-Kin, Bronson, Roderick T, Nguyen, Quang-De, Signoretti, Sabina, Kaelin, Jr, William G

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Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts von Drapkin, Benjamin J, George, Julie, Christensen, Camilla L, Mino-Kenudson, Mari, Dries, Ruben, Sundaresan, Tilak, Phat, Sarah, Myers, David T, Zhong, Jun, Igo, Peter, Hazar-Rethinam, Mehlika H, Licausi, Joseph A, Gomez-Caraballo, Maria, Kem, Marina, Jani, Kandarp N, Azimi, Roxana, Abedpour, Nima, Menon, Roopika, Lakis, Sotirios, Heist, Rebecca S, Büttner, Reinhard, Haas, Stefan, Sequist, Lecia V, Shaw, Alice T, Wong, Kwok-Kin, Hata, Aaron N, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A, Peifer, Martin, Dyson, Nicholas, Thomas, Roman K, Farago, Anna F

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer von Zhang, Hua, Christensen, Camilla L., Dries, Ruben, Oser, Matthew G., Deng, Jiehui, Diskin, Brian, Li, Fei, Pan, Yuanwang, Zhang, Xuzhu, Yin, Yandong, Papadopoulos, Eleni, Pyon, Val, Thakurdin, Cassandra, Kwiatkowski, Nicholas, Jani, Kandarp, Rabin, Alexandra R., Castro, Dayanne M., Chen, Ting, Silver, Heather, Huang, Qingyuan, Bulatovic, Mirna, Dowling, Catríona M., Sundberg, Belen, Leggett, Alan, Ranieri, Michela, Han, Han, Li, Shuai, Yang, Annan, Labbe, Kristen E., Almonte, Christina, Sviderskiy, Vladislav O., Quinn, Max, Donaghue, Jack, Wang, Eric S., Zhang, Tinghu, He, Zhixiang, Velcheti, Vamsidhar, Hammerman, Peter S., Freeman, Gordon J., Bonneau, Richard, Kaelin, William G., Sutherland, Kate D., Kersbergen, Ariena, Aguirre, Andrew J., Yuan, Guo-Cheng, Rothenberg, Eli, Miller, George, Gray, Nathanael S., Wong, Kwok-Kin

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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors von Gao, Yang, Zhang, Tinghu, Terai, Hideki, Ficarro, Scott B., Kwiatkowski, Nicholas, Hao, Ming-Feng, Sharma, Bandana, Christensen, Camilla L., Chipumuro, Edmond, Wong, Kwok-kin, Marto, Jarrod A., Hammerman, Peter S., Gray, Nathanael S., George, Rani E.

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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis von Gallina, Irene, Hendriks, Ivo A., Hoffmann, Saskia, Larsen, Nicolai B., Johansen, Joachim, Colding-Christensen, Camilla S., Schubert, Lisa, Sellés-Baiget, Selene, Fábián, Zita, Kühbacher, Ulrike, Gao, Alan O., Räschle, Markus, Rasmussen, Simon, Nielsen, Michael L., Mailand, Niels, Duxin, Julien P.

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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression von Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L, Abraham, Brian J, Kwiatkowski, Nicholas, Buczkowski, Kevin A, Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L, Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, Tae-Jung, Hong, Sook-Hee, Poudel-Neupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J, Watanabe, Hideo, Gray, Nathanael S, Young, Richard A, Wong, Kwok-Kin, Hammerman, Peter S

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Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1 von Colding-Christensen, Camilla S., Kakulidis, Ellen S., Arroyo-Gomez, Javier, Hendriks, Ivo A., Arkinson, Connor, Fábián, Zita, Gambus, Agnieszka, Mailand, Niels, Duxin, Julien P., Nielsen, Michael L.

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NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model von Liu, Yan, Li, Yuyang, Liu, Shengwu, Adeegbe, Dennis O, Christensen, Camilla L, Quinn, Max M, Dries, Ruben, Han, Shiwei, Buczkowski, Kevin, Wang, Xiaoen, Chen, Ting, Gao, Peng, Zhang, Hua, Li, Fei, Hammerman, Peter S, Bradner, James E, Quayle, Steven N, Wong, Kwok-Kin

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MUC1-C activates EZH2 expression and function in human cancer cells von Rajabi, Hasan, Hiraki, Masayuki, Tagde, Ashujit, Alam, Maroof, Bouillez, Audrey, Christensen, Camilla L., Samur, Mehmet, Wong, Kwok-Kin, Kufe, Donald

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PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53 von ZANDI, Roza, SELIVANOVA, Galina, LAULUND CHRISTENSEN, Camilla, GERDS, Thomas Alexander, WILLUMSEN, Berthe Marie, SKOVGAARD POULSEN, Hans

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CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer von Chipumuro, Edmond, Marco, Eugenio, Christensen, Camilla L., Kwiatkowski, Nicholas, Zhang, Tinghu, Hatheway, Clark M., Abraham, Brian J., Sharma, Bandana, Yeung, Caleb, Altabef, Abigail, Perez-Atayde, Antonio, Wong, Kwok-Kin, Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., George, Rani E.

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High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma von Eliades, Philip, Abraham, Brian J., Ji, Zhenyu, Miller, David M., Christensen, Camilla L., Kwiatkowski, Nicholas, Kumar, Raj, Njauw, Ching Ni, Taylor, Michael, Miao, Benchun, Zhang, Tinghu, Wong, Kwok-Kin, Gray, Nathanael S., Young, Richard A., Tsao, Hensin

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Imaging of atherosclerosis with [64Cu]Cu-DOTA-TATE in a translational head-to-head comparison study with [18F]FDG, and Na[18F]F in rabbits von Grandjean, Constance E., Pedersen, Sune F., Christensen, Camilla, Dibenedetto, Altea, Eriksen, Thomas, Binderup, Tina, Kjaer, Andreas

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Phase II study of uPAR-PET/CT for staging of primary breast cancer in comparison with ultrasound and fine needle biopsies von Fosbøl, Marie Øbro, Carlsen, Esben Andreas, Brandt-Larsen, Malene, Christensen, Camilla, Madsen, Jacob, Loft, Annika, Berthelsen, Anne Kiil, Tvedskov, Tove Filtenborg, Kroman, Niels, Andersen, Kim Francis, von Benzon, Eric, Kjaer, Andreas

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The Acute Effects of Interval- Vs Continuous-Walking Exercise on Glycemic Control in Subjects With Type 2 Diabetes: A Crossover, Controlled Study von Karstoft, Kristian, Christensen, Camilla S, Pedersen, Bente K, Solomon, Thomas P. J

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CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC von Becker, Jeffrey H, Gao, Yandi, Soucheray, Margaret, Pulido, Ines, Kikuchi, Eiki, Rodríguez, María L, Gandhi, Rutu, Lafuente-Sanchis, Aranzazu, Aupí, Miguel, Alcácer Fernández-Coronado, Javier, Martín-Martorell, Paloma, Cremades, Antonio, Galbis-Caravajal, José M, Alcácer, Javier, Christensen, Camilla L, Simms, Patricia, Hess, Ashley, Asahina, Hajime, Kahle, Michael P, Al-Shahrour, Fatima, Borgia, Jeffrey A, Lahoz, Agustín, Insa, Amelia, Juan, Oscar, Jänne, Pasi A, Wong, Kwok-Kin, Carretero, Julian, Shimamura, Takeshi

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Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer von Herter-Sprie, Grit S, Koyama, Shohei, Korideck, Houari, Hai, Josephine, Deng, Jiehui, Li, Yvonne Y, Buczkowski, Kevin A, Grant, Aaron K, Ullas, Soumya, Rhee, Kevin, Cavanaugh, Jillian D, Neupane, Neermala Poudel, Christensen, Camilla L, Herter, Jan M, Makrigiorgos, G Mike, Hodi, F Stephen, Freeman, Gordon J, Dranoff, Glenn, Hammerman, Peter S, Kimmelman, Alec C, Wong, Kwok-Kin

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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice von Akbay, Esra A, Moslehi, Javid, Christensen, Camilla L, Saha, Supriya, Tchaicha, Jeremy H, Ramkissoon, Shakti H, Stewart, Kelly M, Carretero, Julian, Kikuchi, Eiki, Zhang, Haikuo, Cohoon, Travis J, Murray, Stuart, Liu, Wei, Uno, Kazumasa, Fisch, Sudeshna, Jones, Kristen, Gurumurthy, Sushma, Gliser, Camelia, Choe, Sung, Keenan, Marie, Son, Jaekyoung, Stanley, Illana, Losman, Julie A, Padera, Robert, Bronson, Roderick T, Asara, John M, Abdel-Wahab, Omar, Amrein, Philip C, Fathi, Amir T, Danial, Nika N, Kimmelman, Alec C, Kung, Andrew L, Ligon, Keith L, Yen, Katharine E, Kaelin, Jr, William G, Bardeesy, Nabeel, Wong, Kwok-Kin

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