Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance von Tam, Joseph, Cinar, Resat, Liu, Jie, Godlewski, Grzegorz, Wesley, Daniel, Jourdan, Tony, Szanda, Gergő, Mukhopadhyay, Bani, Chedester, Lee, Liow, Jeih-San, Innis, Robert B., Cheng, Kejun, Rice, Kenner C., Deschamps, Jeffrey R., Chorvat, Robert J., McElroy, John F., Kunos, George

Volltext

Peripherally restricted CB1 receptor blockers von Chorvat, Robert J.

Volltext

JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities von Chorvat, Robert J., Berbaum, Jennifer, Seriacki, Kristine, McElroy, John F.

Volltext

Preclinical toxicity evaluation of JD5037, a peripherally restricted CB1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis von Kale, Vijay Pralhad, Gibbs, Seth, Taylor, John A., Zmarowski, Amy, Novak, Joseph, Patton, Kristin, Sparrow, Barney, Gorospe, Jenni, Anand, Satheesh, Cinar, Resat, Kunos, George, Chorvat, Robert J., Terse, Pramod S.

Volltext

Corticotropin-Releasing Hormone Receptor Antagonists:  Framework Design and Synthesis Guided by Ligand Conformational Studies von Hodge, C. Nicholas, Aldrich, Paul E, Wasserman, Zelda R, Fernandez, Christina H, Nemeth, Gregory A, Arvanitis, Argyrios, Cheeseman, Robert S, Chorvat, Robert J, Ciganek, Engelbert, Christos, Thomas E, Gilligan, Paul J, Krenitsky, Paul, Scholfield, Everett, Strucely, Philip

Volltext

Synthesis of S‐2‐((S)‐3‐(4‐chlorophenyl)‐N'‐((4‐chlorophenyl)sulfonyl)‐4‐phenyl‐4,5‐dihydro‐1H‐pyrazole‐1‐carboximidamido)‐3‐(methyl‐d3)butanamide‐d5, octadeuterated JD5037... von Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Chorvat, Robert J., Kunos, George

Volltext

Non-Peptide Corticotropin-Releasing Hormone Antagonists:  Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines von Arvanitis, Argyrios G, Gilligan, Paul J, Chorvat, Robert J, Cheeseman, Robert S, Christos, Thomas E, Bakthavatchalam, Rajagopal, Beck, James P, Cocuzza, Anthony J, Hobbs, Frank W, Wilde, Richard G, Arnold, Charles, Chidester, Dennis, Curry, Matthew, He, Liqi, Hollis, Andrea, Klaczkiewicz, John, Krenitsky, Paul J, Rescinito, Joseph P, Scholfield, Everett, Culp, Steven, De Souza, Errol B, Fitzgerald, Lawrence, Grigoriadis, Dimitri, Tam, S. William, Wong, Y. Nancy, Huang, Shiew-Mei, Shen, Helen L

Volltext

2-Fluoro-4-pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release-Enhancing Agents with Good Efficacy and Duration of Action von Earl, Richard A, Zaczek, Robert, Teleha, Christopher A, Fisher, Barbara N, Maciag, Carla M, Marynowski, Maria E, Logue, Andrew R, Tam, S. William, Tinker, William J, Huang, Shiew-Mei, Chorvat, Robert J

Volltext

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N′-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d3)butanamide-d5, octa-deuterated JD5037 von Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Chorvat, Robert J., Kunos, George

Volltext

Synthesis of S ‐2‐(( S )‐3‐(4‐chlorophenyl)‐ N '‐((4‐chlorophenyl)sulfonyl)‐4‐phenyl‐4,5‐dihydro‐1 H ‐pyrazole‐1‐carboximidamido)‐3‐(methyl‐ d 3 )butanamide‐d 5 , octadeuterated JD... von Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Chorvat, Robert J., Kunos, George

Volltext

ChemInform Abstract: Peripherally Restricted CB1 Receptor Blockers von Chorvat, Robert J.

Volltext

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d 3 )butanamide-d 5 , octadeuterated JD5037 von Iyer, Malliga R, Cinar, Resat, Coffey, Nathan J, Chorvat, Robert J, Kunos, George

Volltext

Synthesis of 4-aryl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyrazines von Chorvat, Robert J, Rorig, Kurt J

Volltext

Preclinical toxicity evaluation of JD5037, a peripherally restricted CB 1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis von Kale, Vijay Pralhad, Gibbs, Seth, Taylor, John A, Zmarowski, Amy, Novak, Joseph, Patton, Kristin, Sparrow, Barney, Gorospe, Jenni, Anand, Satheesh, Cinar, Resat, Kunos, George, Chorvat, Robert J, Terse, Pramod S

Volltext

Ion channel modulators that enhance acetylcholine release: potential therapies for Alzheimer's disease von Chorvat, Robert J, Zaczek, Robert, Brown, Barry S

Volltext

Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: monobasic derivatives of disobutamide von Desai, Bipin N, Fowler, Kerry W, Chorvat, Robert J, Frederick, Leo G, Hatley, Frida R, Rorig, Kurt J, Garthwaite, Susan M

Volltext

ULTRA SHORT ACTING ANTI-ARRHYTHMIC AGENTS von Somberg, John, Chorvat, Robert J

Volltext bestellen

Ultra short acting anti-arrhythmic agents von Somberg, John, Chorvat, Robert J

Volltext bestellen

ULTRA SHORT ACTING ANTI-ARRHYTHMIC AGENTS von Somberg, John, Chorvat, Robert J

Volltext bestellen

Ultra short acting anti-arrhythmic agents von Somberg, John, Chorvat, Robert J

Volltext bestellen