The tertiary structure and domain organization of coagulation factor VIII von Shen, Betty W., Spiegel, Paul Clint, Chang, Chong-Hwan, Huh, Jae-Wook, Lee, Jung-Sik, Kim, Jeanman, Kim, Young-Ho, Stoddard, Barry L.

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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase von Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.

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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus von Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.

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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 von Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L

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Biarylpyrazolyl Oxadiazole as Potent, Selective, Orally Bioavailable Cannabinoid-1 Receptor Antagonists for the Treatment of Obesity von Lee, Suk Ho, Seo, Hee Jeong, Lee, Sung-Han, Jung, Myung Eun, Park, Ji-Hyun, Park, Hyun-Ju, Yoo, Jakyung, Yun, Hoseop, Na, Jooran, Kang, Suk Youn, Song, Kwang-Seop, Kim, Min-ah, Chang, Chong-Hwan, Kim, Jeongmin, Lee, Jinhwa

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Structure of the membrane-bound protein photosynthetic reaction center from Rhodobacter sphaeroides von Chang, Chong Hwan, El-Kabbani, Ossama, Tiede, David, Norris, James, Schiffer, Marianne

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Comparison of reaction centers from Rhodobacter sphaeroides and Rhodopseudomonas viridis: overall architecture and protein-pigment interactions von El-Kabbani, Ossama, Chang, Chong Hwan, Tiede, David, Norris, James, Schiffer, Marianne

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases von Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P

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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies von Jadhav, Prabhakar K, Woerner, Francis J, Lam, Patrick Y. S, Hodge, C. Nicholas, Eyermann, Charles J, Man, Hon-Wah, Daneker, Wayne F, Bacheler, Lee T, Rayner, Marlene M, Meek, James L, Erickson-Viitanen, Susan, Jackson, David A, Calabrese, Joseph C, Schadt, Margaret, Chang, Chong-Hwan

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors von Patrick Y. S. Lam, Jahdav, Prabhakar K., Eyermann, Charles J., Hodge, C. Nicholas, Ru, Yu, Bacheler, Lee T., Meek, James L., Otto, Michael J., Rayner, Marlene M., Wong, Y. Nancy, Chang, Chong-Hwan, Weber, Patricia C., Jackson, David A., Sharpe, Thomas R., Erickson-Viitanen, Susan

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SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa von Qiao, Jennifer X., Chang, Chong-Hwan, Cheney, Daniel L., Morin, Paul E., Wang, Gren Z., King, Sarah R., Wang, Tammy C., Rendina, Alan R., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.

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Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties von Corte, James R., Fang, Tianan, Pinto, Donald J.P., Han, Wei, Hu, Zilun, Jiang, Xiang-Jun, Li, Yun-Long, Gauuan, Jolicia F., Hadden, Mark, Orton, Darren, Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., He, Kan, Morin, Paul E., Chang, Chong-Hwan, Cheney, Daniel L., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.

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Molecular Recognition of Cyclic Urea HIV-1 Protease Inhibitors von Ala, Paul J., DeLoskey, Richard J., Huston, Edward E., Jadhav, Prabhakar K., Lam, Patrick Y.S., Eyermann, Charles J., Hodge, C. Nicholas, Schadt, Margaret C., Lewandowski, Frank A., Weber, Patricia C., McCabe, Denise D., Duke, Jodie L., Chang, Chong-Hwan

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Inhibition of Human Endogenous Retrovirus-K10 Protease in Cell-free and Cell-based Assays von Kuhelj, Robert, Rizzo, Christopher J., Chang, Chong-Hwan, Jadhav, Prabhakar K., Towler, Eric M., Korant, Bruce D.

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Quinazolines as cyclin dependent kinase inhibitors von Sielecki, Thais M., Johnson, Tricia L., Liu, Jie, Muckelbauer, Jodi K., Grafstrom, Robert H., Cox, Sarah, Boylan, John, Burton, Catherine R., Chen, Haiying, Smallwood, Angela, Chang, Chong-Hwan, Boisclair, Michael, Benfield, Pamela A., Trainor, George L., Seitz, Steven P.

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Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas von Lam, Patrick Y. S, Ru, Yu, Jadhav, Prabhakar K, Aldrich, Paul E, DeLucca, George V, Eyermann, Charles J, Chang, Chong-Hwan, Emmett, George, Holler, Edward R, Daneker, Wayne F, Li, Liangzhu, Confalone, Pat N, McHugh, Robert J, Han, Qi, Li, Renhua, Markwalder, Jay A, Seitz, Steven P, Sharpe, Thomas R, Bacheler, Lee T, Rayner, Marlene M, Klabe, Ronald M, Shum, Linyee, Winslow, Dean L, Kornhauser, David M, Jackson, David A, Erickson-Viitanen, Susan, Hodge, C. Nicholas

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Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa von Wei, Anzhi, Alexander, Richard S, Duke, Jodie, Ross, Harold, Rosenfeld, Stuart A, Chang, Chong-Hwan

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Mapping Hydration Water Molecules in the HIV-1 Protease/DMP323 Complex in Solution by NMR Spectroscopy von Wang, Yun-Xing, Freedberg, Darón I, Grzesiek, Stephan, Torchia, Dennis A, Wingfield, Paul T, Kaufman, Joshua D, Stahl, Stephen J, Chang, Chong-Hwan, Hodge, C. Nicholas

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Solvation studies of DMP323 and A76928 bound to HIV protease: Analysis of water sites using grand canonical Monte Carlo simulations von Marrone, Tami J., McCammon, J. Andrew, Resat, Haluk, Hodge, C. Nicholas, Chang, Chong‐Hwan

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Cyclic Urea Amides:  HIV-1 Protease Inhibitors with Low Nanomolar Potency against both Wild Type and Protease Inhibitor Resistant Mutants of HIV von Jadhav, Prabhakar K, Ala, Paul, Woerner, Francis J, Chang, Chong-Hwan, Garber, Sena S, Anton, Elizabeth D, Bacheler, Lee T

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