Design and Structure−Activity Relationships of Potent and Selective Inhibitors of Blood Coagulation Factor Xa von Ewing, William R, Becker, Michael R, Manetta, Vincent E, Davis, Roderick S, Pauls, Henry W, Mason, Helen, Choi-Sledeski, Yong Mi, Green, Daniel, Cha, Don, Spada, Alfred P, Cheney, Daniel L, Mason, Jonathan S, Maignan, Sebastien, Guilloteau, Jean-Pierre, Brown, Karen, Colussi, Dennis, Bentley, Ross, Bostwick, Jeff, Kasiewski, Charles J, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria

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Discovery of the first selective, small-molecule GFRα2/3 inhibitors through DNA-encoded library technology von Johnson, Shea L., Missig, Galen, Wang, Minghua, Ouk, Kosalvisal, Gupta, Kushali, Nguyen, Hanh Nho, Toh, May Fern, Ho, Tammy Szu-Yu, Gray, David, Zhang, Hongjun, Choi-Sledeski, Yong Mi, Barberis, Claude, Stone, David J., Pin, Sokhom, Lim, Jongwon

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Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors von Maignan, Sébastien, Guilloteau, Jean-Pierre, Pouzieux, Stéphanie, Choi-Sledeski, Yong Mi, Becker, Michael R, Klein, Scott I, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P 1 Ligand von Choi-Sledeski, Yong Mi, Kearney, Robert, Poli, Gregory, Pauls, Henry, Gardner, Charles, Gong, Yong, Becker, Michael, Davis, Roderick, Spada, Alfred, Liang, Guyan, Chu, Valeria, Brown, Karen, Collussi, Dennis, Leadley, Robert, Rebello, Sam, Moxey, Phillip, Morgan, Suzanne, Bentley, Ross, Kasiewski, Charles, Maignan, Sebastien, Guilloteau, Jean-Pierre, Mikol, Vincent

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Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders von Thurairatnam, Sukanthini, Lim, Sungtaek, Choi-Sledeski, Yong Mi, Hirth, Bradford H, Jiang, John, Macor, John E, Makino, Elina, Maniar, Sachin, Musick, Kwon, Pribish, James R, Munson, Mark

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A β-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity von Liang, Guyan, Choi-Sledeski, Yong Mi, Shum, Patrick, Chen, Xin, Poli, Gregory B., Kumar, Vasant, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Kang, Jiesheng, Zhang, Ying

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Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors:  Preference for a Neutral Group in the S1 Pocket von Maignan, Sébastien, Guilloteau, Jean-Pierre, Choi-Sledeski, Yong Mi, Becker, Michael R, Ewing, William R, Pauls, Henry W, Spada, Alfred P, Mikol, Vincent

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Dimerization of β-tryptase inhibitors, does it work for both basic and neutral P1 groups? von Liang, Guyan, Choi-Sledeski, Yong Mi, Chen, Xin, Gong, Yong, MacMillan, Eric W., Tsay, Joseph, Sides, Keith, Cairns, Jennifer, Kulitzscher, Berndt, Aldous, David J., Morize, Isabelle, Pauls, Henry W.

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Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P1 Ligand von Choi-Sledeski, Yong Mi, Kearney, Robert, Poli, Gregory, Pauls, Henry, Gardner, Charles, Gong, Yong, Becker, Michael, Davis, Roderick, Spada, Alfred, Liang, Guyan, Chu, Valeria, Brown, Karen, Collussi, Dennis, Leadley, Robert, Rebello, Sam, Moxey, Phillip, Morgan, Suzanne, Bentley, Ross, Kasiewski, Charles, Maignan, Sebastien, Guilloteau, Jean-Pierre, Mikol, Vincent

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A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO) von Liang, Guyan, Choi-Sledeski, Yong Mi, Poli, Gregory, Chen, Xin, Shum, Patrick, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Cairns, Jennifer, Stoklosa, Gregory, Nieduzak, Thaddeus, Zhao, Zhicheng, Wang, Jie, Vaz, Roy J.

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Structure-based design, synthesis, and profiling of a β-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group von Liang, Guyan, Choi-Sledeski, Yong Mi, Poli, Gregory B., Chen, Xin, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Vaz, Roy J.

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Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors von Gong, Y, Becker, M, Choi-Sledeski, Y M, Davis, R S, Salvino, J M, Chu, V, Brown, K D, Pauls, H W

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Sulfonamidopyrrolidinone Factor Xa Inhibitors:  Potency and Selectivity Enhancements via P-1 and P-4 Optimization von Choi-Sledeski, Yong Mi, McGarry, Daniel G, Green, Daniel M, Mason, Helen J, Becker, Michael R, Davis, Roderick S, Ewing, William R, Dankulich, William P, Manetta, Vincent E, Morris, Robert L, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Leadley, Robert J, Maignan, Sebastien, Guilloteau, Jean-Pierre, Dunwiddie, Christopher T, Pauls, Henry W

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Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors von Becker, Michael R., Ewing, William R., Davis, Roderick S., Pauls, Henry W., Ly, Cuong, Li, Aiwen, Mason, Helen J., Choi-Sledeski, Yong Mi, Spada, Alfred P., Chu, Valeria, Brown, Karen D., Colussi, Dennis J., Leadley, Robert J., Bentley, Ross, Bostwick, Jeff, Kasiewski, Charles, Morgan, Suzanne

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Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1H-pyrrolo-pyridin-yl)-methanones and synthesis thereof von POLI, GREGORY B, CHOI-SLEDESKI, YONG MI

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PRODRUGS OF [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF von POLI, GREGORY B, CHOI-SLEDESKI, YONG-MI

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Substituerte propan fosfinsyre estere von COLLIS ALAN JOHN, POLI GREGORY BERNARD, CHOI-SLEDESKI YONG MI

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TREATMENT OF DERMATOLOGICAL ALLERGIC CONDITIONS von FITCH NEIL, MINNICH ANNE, CHOI SLEDESKI YONG MI

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PRODRUGS OF [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF von POLI, GREGORY B, CHOI-SLEDESKI, YONG MI

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PRODRUGS OF [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF von POLI, GREGORY B, CHOI-SLEDESKI, YONG MI

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