Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin von Fenteany, Gabriel, Standaert, Robert F., Lane, William S., Choi, Soongyu, Corey, E. J., Schreiber, Stuart L.

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YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non-Small Cell Lung Cancer von Yun, Jiyeon, Hong, Min Hee, Kim, Seok-Young, Park, Chae-Won, Kim, Soyoung, Yun, Mi Ran, Kang, Han Na, Pyo, Kyoung-Ho, Lee, Sung Sook, Koh, Jong Sung, Song, Ho-Juhn, Kim, Dong Kyun, Lee, Young-Sung, Oh, Se-Woong, Choi, Soongyu, Kim, Hye Ryun, Cho, Byoung Chul

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Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy von Kim, Donghwa, Choi, Sang Won, Cho, Jihee, Been, Jae-Hui, Choi, Kyoungsun, Jiang, Wenzhe, Han, Jaeho, Oh, Jedo, Park, Changmin, Choi, Soongyu, Seo, Songyi, Kim, Koung Li, Suh, Wonhee, Lee, Sang Kook, Kim, Sanghee

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Efficient Assembly of the Phomactin Core via Two Different Macrocyclization Protocols von Houghton, Tom J, Choi, Soongyu, Rawal, Viresh H

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LPU: A Latency-Optimized and Highly Scalable Processor for Large Language Model Inference von Moon, Seungjae, Kim, Jung-Hoon, Kim, Junsoo, Hong, Seongmin, Cha, Junseo, Kim, Minsu, Lim, Sukbin, Choi, Gyubin, Seo, Dongjin, Kim, Jongho, Lee, Hunjong, Park, Hyunjun, Ko, Ryeowook, Choi, Soongyu, Park, Jongse, Lee, Jinwon, Kim, Joo-Young

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SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor von Baiazitov, Ramil Y., Qi, Hongyan, Arasu, Tamil, Lennox, William, Cao, Liangxian, Weetall, Marla, Furia, Bansri, Zhuo, Jin, Choi, Soongyu, Kim, Min Jung, Sheedy, Josephine, Davis, Thomas, Moon, Young-Choon

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Abstract 3915: YH25248, a selective PI3K delta inhibitor, shows synergistic effect with an anti-PD-L1 antibody von Park, Jinhwi, Kang, Ho-Woong, Koo, Hyun-Mo, Park, Jongsuk, Kim, Tae-Wang, Oh, Se-Woong, Choi, Soongyu

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Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy von Woll, Matthew G, Qi, Hongyan, Turpoff, Anthony, Zhang, Nanjing, Zhang, Xiaoyan, Chen, Guangming, Li, Chunshi, Huang, Song, Yang, Tianle, Moon, Young-Choon, Lee, Chang-Sun, Choi, Soongyu, Almstead, Neil G, Naryshkin, Nikolai A, Dakka, Amal, Narasimhan, Jana, Gabbeta, Vijayalakshmi, Welch, Ellen, Zhao, Xin, Risher, Nicole, Sheedy, Josephine, Weetall, Marla, Karp, Gary M

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Development of a novel glucosylceramide synthase (GCS) inhibitor with increased blood-brain barrier penetration for treatment of Gaucher disease von Ahn, Sujin, Kong, Younggyu, Kim, Jung-Hwan, Kim, Donghoon, Kwon, Seulki, Park, Jong-Suk, Chung, Sooyong, Chung, Wonhui, Han, Tae-Dong, Oh, Se-Woong, Choi, Soongyu

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SAT-350-YH25724, a novel long-acting GLP-1/FGF21 dual agonist, exhibits marked anti-fibrotic effects in different experimental models of liver fibrosis von Kim, Dohoon, Kim, Junhwan, Kim, Tae Wang, Hong, Han, Choi, Hyun, Yang, Ji-Eun, Jeong, Da-Na, Ju, Mi Kyeong, Seo, Minji, Kim, Su Kyung, Park, Ju-Young, Choi, Byung Hyun, Kim, Han-Joo, Ahn, Kyoung Kyu, Kim, Jong-Gyun, Bedossa, Pierre, Ratziu, Vlad, Oh, Se-Woong, Choi, Soongyu

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Abstract 4790: YH25448, an irreversible 3rd generation EGFR TKI, exhibits superior anticancer effects with potent brain BBB penetration in NSCLC von Yun, Jiyeon, Hong, Min Hee, Kim, Seok-Young, Park, Chae Won, Kim, So-Young, Yun, Mi Ran, Kang, Han Na, Pyo, Kyoung-Ho, Koh, Jong Sung, Song, Ho-Juhn, Lee, Young- Sung, Oh, Se-Woong, Choi, Soongyu, Cho, Byoung-Chul

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YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results von Cho, Byoung Chul, Han, Ji-Youn, Kim, Sang-We, Lee, Ki Hyeong, Kim, Dong-Wan, Lee, Yun-Gyoo, Lee, Gyeong-won, Lee, Jong-Seok, Cho, Eun Kyung, Kim, Joo-Hang, Lee, Sung Sook, Min, Young Joo, Kim, Jin-Soo, Shin, Sang Won, Kim, HyeRyun, Hong, Min Hee, Ahn, Jin Seok, Choi, Soongyu, Ahn, Myung-Ju

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Abstract 2529: Optimization of small molecules targeting BMI1 protein expression. Part 1. Amino-thiazoles: the first-in-class highly potent inhibitors of BMI1 protein von Sydorenko, Nadiya, Baiazitov, Ramil, Choi, Soongyu, Lee, Chang-Sun, Cao, Liangxian, Davis, Thomas W., Almstead, Neil G., Moon, Young-Choon

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Highly enantioselective routes to darzens and acetate aldol products from achiral aldehydes and t-butyl bromoacetate von Corey, E.J., Choi, Soongyu

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An enantioselective synthesis of ( 6R)-lactacystin von Corey, E.J., Choi, Soongyu

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An enantioselective synthesis of ( 2S, 3S)- and ( 2R, 3S)-3-hydroxyleucine von Correy, E.J., Lee, Duck-Hyung, Choi, Soongyu

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Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives von Smith, Roger A., Fathi, Zahra, Brown, Su-Ellen, Choi, Soongyu, Fan, Jianmei, Jenkins, Susan, Kluender, Harold C.E., Konkar, Anish, Lavoie, Rico, Mays, Ronald, Natoli, Jennifer, O’Connor, Stephen J., Ortiz, Astrid A., Podlogar, Brent, Taing, Christy, Tomlinson, Susan, Tritto, Theresa, Zhang, Zhonghua

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LPU: A Latency-Optimized and Highly Scalable Processor for Large Language Model Inference von Moon, Seungjae, Kim, Jung-Hoon, Kim, Junsoo, Hong, Seongmin, Cha, Junseo, Kim, Minsu, Lim, Sukbin, Choi, Gyubin, Seo, Dongjin, Kim, Jongho, Lee, Hunjong, Park, Hyunjun, Ko, Ryeowook, Choi, Soongyu, Park, Jongse, Lee, Jinwon, Kim, Joo-Young

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate von Wood, Jill, Bagi, Cedo M., Akuche, Christiana, Bacchiocchi, Antonietta, Baryza, Jeremy, Blue, Marie-Luise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James H., Conrad, Patricia, Dixon, Brian R., Ehrlich, Paul P., Gane, Todd, Gunn, David, Joe, Ted, Johnson, Jeffrey S., Jordan, Jerold, Kramss, Richard, Liu, Peiying, Levy, Joan, Lowe, Derek B., McAlexander, Ian, Natero, Reina, Redman, Anikó M., Scott, William J., Town, Christopher, Wang, Ming, Wang, Yamin, Zhang, Zhonghua

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Efficient enantioselective syntheses of chloramphenicol and ( d) -threo- and ( d)- erythro-sphingosine von Corey, E.J., Choi, Soongyu

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