Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester von Shang, Jackie, Tschirret-Guth, Richard, Cancilla, Mark, Samuel, Koppara, Chen, Qing, Chobanian, Harry R, Thomas, Ann, Tong, Wei, Josien, Hubert, Buevich, Alexei V, Mitra, Kaushik

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Highly Regioselective Palladium-Catalyzed Direct Arylation of Oxazole at C-2 or C-5 with Aryl Bromides, Chlorides, and Triflates von Strotman, Neil A, Chobanian, Harry R, Guo, Yan, He, Jiafang, Wilson, Jonathan E

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Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling von Buevich, Alexei V, He, Cyndi Qixin, Pio, Barbara, Samuel, Koppara, Mitra, Kaushik, Sherer, Edward C, Cancilla, Mark T, Chobanian, Harry R

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Differentiation of Deprotonated Acyl‑, N‑, and O‑Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Acti... von Niyonsaba, Edouard, Easton, McKay W, Feng, Erlu, Yu, Zaikuan, Zhang, Zhoupeng, Sheng, Huaming, Kong, John, Easterling, Leah F, Milton, Jacob, Chobanian, Harry R, Deprez, Nicholas R, Cancilla, Mark T, Kilaz, Gozdem, Kenttämaa, Hilkka I

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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent von Pachanski, Michele J, Kirkland, Melissa E, Kosinski, Daniel T, Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W, Chobanian, Harry R, Miller, Michael W, Souza, Sarah, Thomas-Fowlkes, Brande S, Ogawa, Aimie M, Weinglass, Adam B, Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A, Howard, Andrew D, Colletti, Steven L, Trujillo, Maria E

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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic von Jiang, Jinlong, Ding, Fa-Xiang, Zhou, Xiaoyan, Bateman, Thomas J, Dong, Shuzhi, Gu, Xin, Keh deJesus, Reynalda, Pio, Barbara, Tang, Haifeng, Chobanian, Harry R, Levorse, Dorothy, Hu, Mengwei, Thomas-Fowlkes, Brande, Margulis, Michael, Koehler, Martin, Weinglass, Adam, Gibson, Jack, Houle, Kevin, Yudkovitz, Joel, Hampton, Caryn, Pai, Lee-Yuh, Samuel, Koppara, Cutarelli, Timothy, Sullivan, Kathleen, Parmee, Emma R, Davies, Ian, Pasternak, Alexander

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From Functional Fatty Acids to Potent and Selective Natural-Product-Inspired Mimetics via Conformational Profiling von Markham, Lauren E., Koelblen, Thomas, Chobanian, Harry R., Follis, Ariele Viacava, Burris, Thomas P., Micalizio, Glenn C.

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A Modular Synthesis of 2-Alkyl- and 2-Arylchromans via a Three-Step Sequence von Orr, Robert K., Campeau, Louis-Charles, Chobanian, Harry R., McCabe Dunn, Jamie M., Pio, Barbara, Plummer, Christopher W., Nolting, Andrew, Ruck, Rebecca T.

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 von Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

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Catalyst-Controlled Regioselective Suzuki Couplings at Both Positions of Dihaloimidazoles, Dihalooxazoles, and Dihalothiazoles von Strotman, Neil A, Chobanian, Harry R, He, Jiafang, Guo, Yan, Dormer, Peter G, Jones, Christina M, Steves, Janelle E

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs von Pio, Barbara, Chobanian, Harry R., Guo, Yan, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Ashley, Eric, Orr, Robert, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Samuel, Koppara, Chen, Qing, Shang, Jackie, Lamca, James, Ehrhart, Juliann, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.

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Synthesis of novel 2-azabicyclo[3.1.1]heptane-5-carboxylic acid von He, Shuwen, Hao, Jinsong, Ashley, Eric R., Chobanian, Harry R., Pio, Barbara, Colletti, Steven L., Miller, Michael

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The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics von Chobanian, Harry R., Guo, Yan, Pio, Barbara, Tang, Haifeng, Teumelsan, Nardos, Clements, Matthew, Frie, Jessica, Ferguson, Ronald, Guo, Zach, Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit, Hampton, Caryn, Pai, Lee-Yuh, Corona, Aaron, Metzger, Joseph, Tong, Vincent, Joshi, Elizabeth M., Xu, Ling, Owens, Karen, Maloney, Kevin, Sullivan, Kathleen, Pasternak, Alexander

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Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs von Chen, Helen Y., Plummer, Christopher W., Xiao, Dong, Chobanian, Harry R., DeMong, Duane, Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Souza, Sarah, Tatosian, Daniel A., Chen, Qing, Hafey, Michael J., Houle, Robert, Nolting, Andrew F., Orr, Robert, Ehrhart, Juliann, Weinglass, Adam B., Tschirret-Guth, Richard, Howard, Andrew D., Colletti, Steven L.

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Synthesis of a Lactone Diastereomer of the Cembranolide Uprolide D von Marshall, James A, Griot, Céline A, Chobanian, Harry R, Myers, William H

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain von Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc D, Fung, Selena, Lanza, Thomas J, Chang, Linda, Bakshi, Raman K, Dellureficio, James P, Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M, Krska, Shane W, Makarewicz, Amanda K, Martel, Elliot J, Leone, Joseph F, Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L, Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P, Shiao, Lin-Lin, Sullivan, Kathleen M, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S, DeVita, Robert J

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization von Chobanian, Harry R., Guo, Yan, Liu, Ping, Lanza, Thomas J., Chioda, Marc, Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Raustad, Katie, Wang, Sheng-Ping, Strack, Alison M., Gorski, Judith N., Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G., Schafer, Wes A., Welch, Christopher J., Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Reitman, Marc L., Nargund, Ravi P., Lin, Linus S.

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity von Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc, Lanza, Thomas J, Chang, Linda, Kelly, Theresa M, Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J, Metzger, Joseph M, Gorski, Judith N, Raustad, Kate, Wang, Sheng-Ping, Strack, Alison M, Miller, Randy, Pang, Jianmei, Madeira, Maria, Lyons, Kathy, Dragovic, Jasminka, Reitman, Marc L, Nargund, Ravi P, Lin, Linus S

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Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement von Chobanian, Harry R, Pio, Barbara, Guo, Yan, Shen, Hong, Huffman, Mark A, Madeira, Maria, Salituro, Gino, Terebetski, Jenna L, Ormes, James, Jochnowitz, Nina, Hoos, Lizbeth, Zhou, Yuchen, Lewis, Dale, Hawes, Brian, Mitnaul, Lyndon, O’Neill, Kim, Ellsworth, Kenneth, Wang, Liangsu, Biftu, Tesfaye, Duffy, Joseph L

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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase von Liu, Ping, Hamill, Terence G, Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S, Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L, Leone, Joseph F, Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A, Nargund, Ravi P, DeVita, Robert J

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