Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation von Pomaville, Monica, Chennakesavalu, Mohansrinivas, Wang, Pingluan, Jiang, Zhiwei, Sun, Hui-Lung, Ren, Peizhe, Borchert, Ryan, Gupta, Varsha, Ye, Chang, Ge, Ruiqi, Zhu, Zhongyu, Brodnik, Mallory, Zhong, Yuhao, Moore, Kelley, Salwen, Helen, George, Rani E., Krajewska, Malgorzata, Chlenski, Alexandre, Applebaum, Mark A., He, Chuan, Cohn, Susan L.

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Methylation of CASP8, DCR2, and HIN-1 in Neuroblastoma Is Associated with Poor Outcome von QIWEI YANG, KIERNAN, Colleen M, YUFENG TIAN, SALWEN, Helen R, CHLENSKI, Alexandre, BRUMBACK, Babette A, LONDON, Wendy B, COHN, Susan L

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Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone von Chlenski, Alexandre, Guerrero, Lisa J, Salwen, Helen R, Yang, Qiwei, Tian, Yufeng, Morales La Madrid, Andres, Mirzoeva, Salida, Bouyer, Patrice G, Xu, David, Walker, Matthew, Cohn, Susan L

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Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors von Chlenski, Alexandre, Guerrero, Lisa J, Peddinti, Radhika, Spitz, Jared A, Leonhardt, Payton T, Yang, Qiwei, Tian, Yufeng, Salwen, Helen R, Cohn, Susan L

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Androgen receptor expression in androgen-independent prostate cancer cell lines von Chlenski, Alexandre, Nakashiro, Koh-ichi, Ketels, Kathleen V., Korovaitseva, Galina I., Oyasu, Ryoichi

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Adrenergic and mesenchymal signatures are identifiable in cell‐free DNA and correlate with metastatic disease burden in children with neuroblastoma von Vayani, Omar R., Kaufman, Maria E., Moore, Kelley, Chennakesavalu, Mohansrinivas, TerHaar, Rachel, Chaves, Gepoliano, Chlenski, Alexandre, He, Chuan, Cohn, Susan L., Applebaum, Mark A.

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Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma von Chlenski, Alexandre, Park, Chanyoung, Dobratic, Marija, Salwen, Helen R, Budke, Brian, Park, Jae-Hyun, Miller, Ryan, Applebaum, Mark A, Wilkinson, Emma, Nakamura, Yusuke, Connell, Philip P, Cohn, Susan L

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Abstract PR16: Whole-genome analysis of the epigenetic mark 5-hydroxymethylcytosine reveals differential profiles in low- , intermediate- , and high-risk neuroblastomas von Applebaum, Mark A., Barr, Erin, Nie, Ji, Uppal, Sakshi, Zhang, Wei, Chlenski, Alexandre, Salwen, Helen, Dobratic, Marija, Stranger, Barbara, Godley, Lucy, He, Chuan, Cohn, Susan L.

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Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma von Gu, Song, Tian, Yufeng, Chlenski, Alexandre, Salwen, Helen R, Lu, Ziyan, Raj, J Usha, Yang, Qiwei

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Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures von Kaufman, Maria E, Vayani, Omar R, Moore, Kelley, Chlenski, Alexandre, Wu, Tong, Lee, Sang Mee, Desai, Ami V, He, Chuan, Cohn, Susan L, Applebaum, Mark A

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Abstract A2-55: Identification of evolutionarily conserved hypoxia-induced genomic pathways responsible for aggressive neuroblastoma phenotypes von Applebaum, Mark A., Jha, Aashish R., Chlenski, Alexandre, Hernandez, Kyle, Mariani, Christopher J., Stranger, Barbara E., Cohn, Susan L.

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Abstract B1-15: Identification of evolutionarily conserved hypoxia-induced genomic pathways responsible for aggressive neuroblastoma phenotypes von Aplebaum, Mark A., Jha, Aashish R., Chlenski, Alexandre, Hernandez, Kyle, Mariani, Christopher J., Stranger, Barbara E., Cohn, Susan L.

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Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients von Applebaum, Mark A, Jha, Aashish R, Kao, Clara, Hernandez, Kyle M, DeWane, Gillian, Salwen, Helen R, Chlenski, Alexandre, Dobratic, Marija, Mariani, Christopher J, Godley, Lucy A, Prabhakar, Nanduri, White, Kevin, Stranger, Barbara E, Cohn, Susan L

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Abstract A01: Evaluation of hypoxia adaptation in neuroblastoma identifies reproducible transcriptional and phenotypic responses von Aplebaum, Mark A., Jha, Aashish, Chlenski, Alexandre, Mariani, Christopher, Kao, Clara, Nelson, Mildred, Hernandez, Kyle, Salwen, Helen, Dobratic, Marija, White, Kevin, Stranger, Barbara, Cohn, Susan L.

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SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix von Chlenski, Alexandre, Liu, Shuqing, Guerrero, Lisa J., Yang, Qiwei, Tian, Yufeng, Salwen, Helen R., Zage, Peter, Cohn, Susan L.

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Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids von Chlenski, Alexandre, Dobratic, Marija, Salwen, Helen R, Applebaum, Mark, Guerrero, Lisa J, Miller, Ryan, DeWane, Gillian, Solomaha, Elena, Marks, Jeremy D, Cohn, Susan L

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SPARC is a key schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis von CHLENSKI, Alexandre, SHUQING LIU, COHN, Susan L, CRAWFORD, Susan E, VOLPERT, Olga V, DEVRIES, George H, EVANGELISTA, Amy, QIWEI YANG, SALWEN, Helen R, FARRER, Robert, BRAY, James

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Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth von Kakodkar, Nisha C., Peddinti, Radhika R., Tian, Yufeng, Guerrero, Lisa J., Chlenski, Alexandre, Yang, Qiwei, Salwen, Helen R., Maitland, Michael L., Cohn, Susan L.

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Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC von CHLENSKI, Alexandre, SHUQING LIU, BAKER, Lisa J, QIWEI YANG, YUFENG TIAN, SALWEN, Helen R, COHN, Susan L

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The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth von Kakodkar, Nisha C., Peddinti, Radhika, Kletzel, Morris, Tian, Yufeng, Guerrero, Lisa J., Undevia, Samir D., Geary, David, Chlenski, Alexandre, Yang, Qiwei, Salwen, Helen R., Cohn, Susan L.

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