The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia von Pappano, William N, Guo, Jun, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Osterling, Donald J, Gao, Wenqing, Spence, Julie K, Pliushchev, Marina, Sweis, Ramzi F, Buchanan, Fritz G, Michaelides, Michael R, Shoemaker, Alexander R, Tse, Chris, Chiang, Gary G

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Targeting the mTOR signaling network in cancer von Chiang, Gary G, Abraham, Robert T

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Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase von Chiang, Gary G, Abraham, Robert T

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase von Ernst, Justin T, Thompson, Peggy A, Nilewski, Christian, Sprengeler, Paul A, Sperry, Samuel, Packard, Garrick, Michels, Theodore, Xiang, Alan, Tran, Chinh, Wegerski, Christopher J, Eam, Boreth, Young, Nathan P, Fish, Sarah, Chen, Joan, Howard, Haleigh, Staunton, Jocelyn, Molter, Jolene, Clarine, Jeff, Nevarez, Andres, Chiang, Gary G, Appleman, Jim R, Webster, Kevin R, Reich, Siegfried H

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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours von Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

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Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition von Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R

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Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect von Scott, David A, Richardson, Adam D, Filipp, Fabian V, Knutzen, Christine A, Chiang, Gary G, Ronai, Ze'ev A, Osterman, Andrei L, Smith, Jeffrey W

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Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome von Kuzuoglu-Ozturk, Duygu, Hu, Zhiqiang, Rama, Martina, Devericks, Emily, Weiss, Jacob, Chiang, Gary G., Worland, Stephen T., Brenner, Steven E., Goodarzi, Hani, Gilbert, Luke A., Ruggero, Davide

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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a von Sweis, Ramzi F, Pliushchev, Marina, Brown, Peter J, Guo, Jun, Li, Fengling, Maag, David, Petros, Andrew M, Soni, Nirupama B, Tse, Chris, Vedadi, Masoud, Michaelides, Michael R, Chiang, Gary G, Pappano, William N

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Polymer-Supported Copper Complex for C−N and C−O Cross-Coupling Reactions with Aryl Boronic Acids von Chiang, Gary C. H, Olsson, Thomas

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Control of mTORC1 signaling by the Opitz syndrome protein MID1 von Liu, Enbo, Knutzen, Christine A, Krauss, Sybille, Schweiger, Susann, Chiang, Gary G

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Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A von Thompson, Peggy A, Eam, Boreth, Young, Nathan P, Fish, Sarah, Chen, Joan, Barrera, Maria, Howard, Haleigh, Sung, Eric, Parra, Ana, Staunton, Jocelyn, Chiang, Gary G, Gerson-Gurwitz, Adina, Wegerski, Christopher J, Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Nilewski, Christian, Packard, Garrick K, Michels, Theodore, Tran, Chinh, Sprengeler, Paul A, Ernst, Justin T, Reich, Siegfried H, Webster, Kevin R

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Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors von Gerson-Gurwitz, Adina, Young, Nathan P, Goel, Vikas K, Eam, Boreth, Stumpf, Craig R, Chen, Joan, Fish, Sarah, Barrera, Maria, Sung, Eric, Staunton, Jocelyn, Chiang, Gary G, Webster, Kevin R, Thompson, Peggy A

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Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway von Zhang, You-Wei, Otterness, Diane M., Chiang, Gary G., Xie, Weilin, Liu, Yun-Cai, Mercurio, Frank, Abraham, Robert T.

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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding von Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.

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The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures von Howes, Amy L, Chiang, Gary G, Lang, Elizabeth S, Ho, Caroline B, Powis, Garth, Vuori, Kristiina, Abraham, Robert T

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The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control von Tsuji, Toshiya, Lau, Eric, Chiang, Gary G., Jiang, Wei

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Discovery of A‑893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 von Sweis, Ramzi F., Wang, Zhi, Algire, Mikkel, Arrowsmith, Cheryl H., Brown, Peter J., Chiang, Gary G., Guo, Jun, Jakob, Clarissa G., Kennedy, Steven, Li, Fengling, Maag, David, Shaw, Bailin, Soni, Nirupama B., Vedadi, Masoud, Pappano, William N.

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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase von Katiyar, Samiksha, Liu, Enbo, Knutzen, Christine A, Lang, Elizabeth S, Lombardo, Christian R, Sankar, Sabita, Toth, Julia I, Petroski, Matthew D, Ronai, Ze'ev, Chiang, Gary G

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Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis von Lu, Zhi Hong, Shvartsman, Mark B, Lee, Andrew Y, Shao, Jenny M, Murray, Mollianne M, Kladney, Raleigh D, Fan, Dong, Krajewski, Stan, Chiang, Gary G, Mills, Gordon B, Arbeit, Jeffrey M

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