“Real world” use of a highly reliable imaging sign: “T2-FLAIR mismatch” for identification of IDH mutant astrocytomas von Jain, Rajan, Johnson, Derek R, Patel, Sohil H, Castillo, Mauricio, Smits, Marion, van den Bent, Martin J, Chi, Andrew S, Cahill, Daniel P

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T2-FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project von Patel, Sohil H, Poisson, Laila M, Brat, Daniel J, Zhou, Yueren, Cooper, Lee, Snuderl, Matija, Thomas, Cheddhi, Franceschi, Ana M, Griffith, Brent, Flanders, Adam E, Golfinos, John G, Chi, Andrew S, Jain, Rajan

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains von Ku, Manching, Koche, Richard P, Rheinbay, Esther, Mendenhall, Eric M, Endoh, Mitsuhiro, Mikkelsen, Tarjei S, Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S, Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M, Cowan, Chad A, Lander, Eric S, Koseki, Haruhiko, Bernstein, Bradley E

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GC-rich sequence elements recruit PRC2 in mammalian ES cells von Mendenhall, Eric M, Koche, Richard P, Truong, Thanh, Zhou, Vicky W, Issac, Biju, Chi, Andrew S, Ku, Manching, Bernstein, Bradley E

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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells von Suvà, Mario L., Rheinbay, Esther, Gillespie, Shawn M., Patel, Anoop P., Wakimoto, Hiroaki, Rabkin, Samuel D., Riggi, Nicolo, Chi, Andrew S., Cahill, Daniel P., Nahed, Brian V., Curry, William T., Martuza, Robert L., Rivera, Miguel N., Rossetti, Nikki, Kasif, Simon, Beik, Samantha, Kadri, Sabah, Tirosh, Itay, Wortman, Ivo, Shalek, Alex K., Rozenblatt-Rosen, Orit, Regev, Aviv, Louis, David N., Bernstein, Bradley E.

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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion von Tateishi, Kensuke, Wakimoto, Hiroaki, Iafrate, A. John, Tanaka, Shota, Loebel, Franziska, Lelic, Nina, Wiederschain, Dmitri, Bedel, Olivier, Deng, Gejing, Zhang, Bailin, He, Timothy, Shi, Xu, Gerszten, Robert E., Zhang, Yiyun, Yeh, Jing-Ruey J., Curry, William T., Zhao, Dan, Sundaram, Sudhandra, Nigim, Fares, Koerner, Mara V.A., Ho, Quan, Fisher, David E., Roider, Elisabeth M., Kemeny, Lajos V., Samuels, Yardena, Flaherty, Keith T., Batchelor, Tracy T., Chi, Andrew S., Cahill, Daniel P.

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Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy von Cui, Xin, Ma, Chao, Vasudevaraja, Varshini, Serrano, Jonathan, Tong, Jie, Peng, Yansong, Delorenzo, Michael, Shen, Guomiao, Frenster, Joshua, Morales, Renee-Tyler Tan, Qian, Weiyi, Tsirigos, Aristotelis, Chi, Andrew S, Jain, Rajan, Kurz, Sylvia C, Sulman, Erik P, Placantonakis, Dimitris G, Snuderl, Matija, Chen, Weiqiang

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Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate von Andronesi, Ovidiu C., Arrillaga-Romany, Isabel C., Ly, K. Ina, Bogner, Wolfgang, Ratai, Eva M., Reitz, Kara, Iafrate, A. John, Dietrich, Jorg, Gerstner, Elizabeth R., Chi, Andrew S., Rosen, Bruce R., Wen, Patrick Y., Cahill, Daniel P., Batchelor, Tracy T.

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A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma von Arrillaga-Romany, Isabel, Chi, Andrew S, Allen, Joshua E, Oster, Wolfgang, Wen, Patrick Y, Batchelor, Tracy T

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An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma von Rheinbay, Esther, Suvà, Mario L., Gillespie, Shawn M., Wakimoto, Hiroaki, Patel, Anoop P., Shahid, Mohammad, Oksuz, Ozgur, Rabkin, Samuel D., Martuza, Robert L., Rivera, Miguel N., Louis, David N., Kasif, Simon, Chi, Andrew S., Bernstein, Bradley E.

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Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate von Andronesi, Ovidiu C, Loebel, Franziska, Bogner, Wolfgang, Marjańska, Małgorzata, Vander Heiden, Matthew G, Iafrate, A John, Dietrich, Jorg, Batchelor, Tracy T, Gerstner, Elizabeth R, Kaelin, William G, Chi, Andrew S, Rosen, Bruce R, Cahill, Daniel P

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A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma von Tateishi, Kensuke, Miyake, Yohei, Kawazu, Masahito, Sasaki, Nobuyoshi, Nakamura, Taishi, Sasame, Jo, Yoshii, Yukie, Ueno, Toshihide, Miyake, Akio, Watanabe, Jun, Matsushita, Yuko, Shiba, Norio, Udaka, Naoko, Ohki, Kentaro, Fink, Alexandria L, Tummala, Shilpa S, Natsumeda, Manabu, Ikegaya, Naoki, Nishi, Mayuko, Ohtake, Makoto, Miyazaki, Ryohei, Suenaga, Jun, Murata, Hidetoshi, Aoki, Ichio, Miller, Julie J, Fujii, Yukihiko, Ryo, Akihide, Yamanaka, Shoji, Mano, Hiroyuki, Cahill, Daniel P, Wakimoto, Hiroaki, Chi, Andrew S, Batchelor, Tracy T, Nagane, Motoo, Ichimura, Koichi, Yamamoto, Tetsuya

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Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma von Tateishi, Kensuke, Iafrate, A John, Ho, Quan, Curry, William T, Batchelor, Tracy T, Flaherty, Keith T, Onozato, Maristela L, Lelic, Nina, Sundaram, Sudhandra, Cahill, Daniel P, Chi, Andrew S, Wakimoto, Hiroaki

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Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation von Batchelor, Tracy T., Gerstner, Elizabeth R., Emblem, Kyrre E., Duda, Dan G., Kalpathy-Cramer, Jayashree, Snuderl, Matija, Ancukiewicz, Marek, Polaskova, Pavlina, Pinho, Marco C., Jennings, Dominique, Plotkin, Scott R., Chi, Andrew S., Eichler, April F., Dietrich, Jorg, Hochberg, Fred H., Lu-Emerson, Christine, lafrate, A. John, Ivy, Percy, Rosen, Bruce R., Loeffler, Jay S., Wen, Patrick Y., Sorensen, Greg, Jain, Rakesh K.

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The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1 -Mutant Cancers and Potentiates NAD + Depletion-Mediated Cytotoxicity von Tateishi, Kensuke, Higuchi, Fumi, Miller, Julie J, Koerner, Mara V A, Lelic, Nina, Shankar, Ganesh M, Tanaka, Shota, Fisher, David E, Batchelor, Tracy T, Iafrate, A John, Wakimoto, Hiroaki, Chi, Andrew S, Cahill, Daniel P

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Brain tumor cells in circulation are enriched for mesenchymal gene expression von Sullivan, James P, Nahed, Brian V, Madden, Marissa W, Oliveira, Samantha M, Springer, Simeon, Bhere, Deepak, Chi, Andrew S, Wakimoto, Hiroaki, Rothenberg, S Michael, Sequist, Lecia V, Kapur, Ravi, Shah, Khalid, Iafrate, A John, Curry, William T, Loeffler, Jay S, Batchelor, Tracy T, Louis, David N, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A

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Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma von Spino, Marissa, Kurz, Sylvia C, Chiriboga, Luis, Serrano, Jonathan, Zeck, Briana, Sen, Namita, Patel, Seema, Shen, Guomiao, Vasudevaraja, Varshini, Tsirigos, Aristotelis, Suryadevara, Carter M, Frenster, Joshua D, Tateishi, Kensuke, Wakimoto, Hiroaki, Jain, Rajan, Riina, Howard A, Nicolaides, Theodore P, Sulman, Erik P, Cahill, Daniel P, Golfinos, John G, Isse, Kumiko, Saunders, Laura R, Zagzag, David, Placantonakis, Dimitris G, Snuderl, Matija, Chi, Andrew S

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Prevalence and pattern of gluteus medius and minimus tendon pathology and muscle atrophy in older individuals using MRI von Chi, Andrew S., Long, Suzanne S., Zoga, Adam C., Read, Paul J., Deely, Diane M., Parker, Laurence, Morrison, William B.

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Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2 von Modrek, Aram S., Golub, Danielle, Khan, Themasap, Bready, Devin, Prado, Jod, Bowman, Christopher, Deng, Jingjing, Zhang, Guoan, Rocha, Pedro P., Raviram, Ramya, Lazaris, Charalampos, Stafford, James M., LeRoy, Gary, Kader, Michael, Dhaliwal, Joravar, Bayin, N. Sumru, Frenster, Joshua D., Serrano, Jonathan, Chiriboga, Luis, Baitalmal, Rabaa, Nanjangud, Gouri, Chi, Andrew S., Golfinos, John G., Wang, Jing, Karajannis, Matthias A., Bonneau, Richard A., Reinberg, Danny, Tsirigos, Aristotelis, Zagzag, David, Snuderl, Matija, Skok, Jane A., Neubert, Thomas A., Placantonakis, Dimitris G.

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Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants von Hayes, Tikvah K., Aquilanti, Elisa, Persky, Nicole S., Yang, Xiaoping, Kim, Erica E., Brenan, Lisa, Goodale, Amy B., Alan, Douglas, Sharpe, Ted, Shue, Robert E., Westlake, Lindsay, Golomb, Lior, Silverman, Brianna R., Morris, Myshal D., Fisher, Ty Running, Beyene, Eden, Li, Yvonne Y., Cherniack, Andrew D., Piccioni, Federica, Hicks, J. Kevin, Chi, Andrew S., Cahill, Daniel P., Dietrich, Jorg, Batchelor, Tracy T., Root, David E., Johannessen, Cory M., Meyerson, Matthew

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