Germline BAP1 mutations predispose to malignant mesothelioma von Testa, Joseph R, Carbone, Michele, Cheung, Mitchell, Pei, Jianming, Below, Jennifer E, Tan, Yinfei, Sementino, Eleonora, Cox, Nancy J, Dogan, A Umran, Pass, Harvey I, Trusa, Sandra, Hesdorffer, Mary, Nasu, Masaki, Powers, Amy, Rivera, Zeyana, Comertpay, Sabahattin, Tanji, Mika, Gaudino, Giovanni, Yang, Haining

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Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations von Kadariya, Yuwaraj, Cheung, Mitchell, Xu, Jinfei, Pei, Jianming, Sementino, Eleonora, Menges, Craig W, Cai, Kathy Q, Rauscher, Frank J, Klein-Szanto, Andres J, Testa, Joseph R

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Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma von JINFEI XU, KADARIYA, Yuwaraj, HONGZHUANG PENG, KARAR, Jayashree, RAUSCHER, Frank J, TESTA, Joseph R, CHEUNG, Mitchell, JIANMING PEI, TALARCHEK, Jacqueline, SEMENTINO, Eleonora, YINFEI TAN, MENGES, Craig W, CAI, Kathy Q, LITWIN, Samuel

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Deregulated Akt3 activity promotes development of malignant melanoma von STAHL, Jill M, SHARMA, Arati, CHEUNG, Mitchell, ZIMMERMAN, Melissa, CHENG, Jin Q, BOSENBERG, Marcus W, KESTER, Mark, SANDIRASEGARANE, Lakshman, ROBERTSON, Gavin P

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RAD001 Inhibits Human Ovarian Cancer Cell Proliferation, Enhances Cisplatin-Induced Apoptosis, and Prolongs Survival in an Ovarian Cancer Model von Mabuchi, Seiji, Altomare, Deborah A, Cheung, Mitchell, Zhang, Lili, Poulikakos, Poulikos I, Hensley, Harvey H, Schilder, Russell J, Ozols, Robert F, Testa, Joseph R

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Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling von YINFEI TAN, CHEUNG, Mitchell, JIANMING PEI, MENGES, Craig W, GODWIN, Andrew K, TESTA, Joseph R

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Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent von Altomare, Deborah A, Rybak, Susanna M, Pei, Jianming, Maizel, Jacob V, Cheung, Mitchell, Testa, Joseph R, Shogen, Kuslima

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Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent von Karbowniczek, Magdalena, Cash, Timothy, Cheung, Mitchell, Robertson, Gavin P, Astrinidis, Aristotelis, Henske, Elizabeth Petri

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BAP1, a tumor suppressor gene driving malignant mesothelioma von Cheung, Mitchell, Testa, Joseph R.

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Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer von Ohar, Jill A, Cheung, Mitchell, Talarchek, Jacqueline, Howard, Suzanne E, Howard, Timothy D, Hesdorffer, Mary, Peng, Hongzhuang, Rauscher, Frank J, Testa, Joseph R

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Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors von Cheung, Mitchell, Kadariya, Yuwaraj, Sementino, Eleonora, Hall, Michael J, Cozzi, Ilaria, Ascoli, Valeria, Ohar, Jill A, Testa, Joseph R

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Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development von Cheung, Mitchell, Sharma, Arati, Madhunapantula, SubbaRao V., Robertson, Gavin P.

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Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma von Tan, Yinfei, Sementino, Eleonora, Cheung, Mitchell, Peri, Suraj, Menges, Craig W., Kukuyan, Anna-Mariya, Zhang, Ting, Khazak, Vladimir, Fox, Lauren A., Ross, Eric A., Ramanathan, Suresh, Jhanwar, Suresh C., Flores, Raja M., Balachandran, Siddharth, Testa, Joseph R.

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Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models von Kukuyan, Anna-Mariya, Sementino, Eleonora, Kadariya, Yuwaraj, Menges, Craig W, Cheung, Mitchell, Tan, Yinfei, Cai, Kathy Q, Slifker, Michael J, Peri, Suraj, Klein-Szanto, Andres J, Rauscher, 3rd, Frank J, Testa, Joseph R

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Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene–environment interaction von Cheung, Mitchell, Kadariya, Yuwaraj, Talarchek, Jacqueline, Pei, Jianming, Ohar, Jill A, Kayaleh, Omar R, Testa, Joseph R

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Abstract 1232: Familial mesothelioma: Beyond BAP1 von Cheung, Mitchell, Ohar, Jill A., Howard, Suzanne E., Howard, Timothy D., Hesdorffer, Mary, Testa, Joseph R.

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Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling von Sementino, Eleonora, Kadariya, Yuwaraj, Cheung, Mitchell, Menges, Craig W, Tan, Yinfei, Kukuyan, Anna-Mariya, Shrestha, Ujjawal, Karchugina, Sofiia, Cai, Kathy Q, Peri, Suraj, Duncan, James S, Chernoff, Jonathan, Testa, Joseph R

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Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains von Peng, Hongzhuang, Prokop, Jeremy, Karar, Jayashree, Park, Kyewon, Cao, Li, Harbour, J William, Bowcock, Anne M, Malkowicz, S Bruce, Cheung, Mitchell, Testa, Joseph R, Rauscher, 3rd, Frank J

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Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma von Kadariya, Yuwaraj, Menges, Craig W, Talarchek, Jacqueline, Cai, Kathy Q, Klein-Szanto, Andres J, Pietrofesa, Ralph A, Christofidou-Solomidou, Melpo, Cheung, Mitchell, Mossman, Brooke T, Shukla, Arti, Testa, Joseph R

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Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase von Peng, Hongzhuang, Cassel, Joel, McCracken, Daniel S., Prokop, Jeremy W., Sementino, Eleonora, Cheung, Mitchell, Collop, Paul R., Polo, Alexander, Joshi, Surbhi, Mandell, Jacob P., Ayyanathan, Kasirajan, Hinds, David, Malkowicz, S. Bruce, Harbour, J. William, Bowcock, Anne M., Salvino, Joseph, Kennedy, Eileen J., Testa, Joseph R., Rauscher, Frank J.

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