Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders von Cisar, Justin S, Weber, Olivia D, Clapper, Jason R, Blankman, Jacqueline L, Henry, Cassandra L, Simon, Gabriel M, Alexander, Jessica P, Jones, Todd K, Ezekowitz, R. Alan B, O’Neill, Gary P, Grice, Cheryl A

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Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase von Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillán, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.

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Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators von Clapper, Jason R., Henry, Cassandra L., Niphakis, Micah J., Knize, Anna M., Coppola, Aundrea R., Simon, Gabriel M., Ngo, Nhi, Herbst, Rachel A., Herbst, Dylan M., Reed, Alex W., Cisar, Justin S., Weber, Olivia D., Viader, Andreu, Alexander, Jessica P., Cunningham, Mark L., Jones, Todd K., Fraser, Iain P., Grice, Cheryl A., Ezekowitz, R. Alan B., O’Neill, Gary P., Blankman, Jacqueline L.

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Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis von Gomez, Laurent, Hack, Michael D., Wu, Jiejun, Wiener, John J.M., Venkatesan, Hari, Santillán, Alejandro, Pippel, Daniel J., Mani, Neelakandha, Morrow, Brian J., Motley, S. Timothy, Shaw, Karen Joy, Wolin, Ronald, Grice, Cheryl A., Jones, Todd K.

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The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists von Jablonowski, Jill A, Grice, Cheryl A, Chai, Wenying, Dvorak, Curt A, Venable, Jennifer D, Kwok, Annette K, Ly, Kiev S, Wei, Jianmei, Baker, Sherry M, Desai, Pragnya J, Jiang, Wen, Wilson, Sandy J, Thurmond, Robin L, Karlsson, Lars, Edwards, James P, Lovenberg, Timothy W, Carruthers, Nicholas I

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Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides:  Potent Human Histamine H4 Antagonists von Venable, Jennifer D, Cai, Hui, Chai, Wenying, Dvorak, Curt A, Grice, Cheryl A, Jablonowski, Jill A, Shah, Chandra R, Kwok, Annette K, Ly, Kiev S, Pio, Barbara, Wei, Jianmei, Desai, Pragnya J, Jiang, Wen, Nguyen, Steven, Ling, Ping, Wilson, Sandy J, Dunford, Paul J, Thurmond, Robin L, Lovenberg, Timothy W, Karlsson, Lars, Carruthers, Nicholas I, Edwards, James P

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Discovery of a novel series of selective HCN1 blockers von McClure, Kelly J., Maher, Michael, Wu, Nancy, Chaplan, Sandra R., Eckert, William A., Lee, Dong H., Wickenden, Alan D., Hermann, Michelle, Allison, Brett, Hawryluk, Natalie, Breitenbucher, J. Guy, Grice, Cheryl A.

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains von Wiener, John J.M., Gomez, Laurent, Venkatesan, Hariharan, Santillán, Alejandro, Allison, Brett D., Schwarz, Kimberly L., Shinde, Shirin, Tang, Liu, Hack, Michael D., Morrow, Brian J., Motley, S. Timothy, Goldschmidt, Raul M., Shaw, Karen Joy, Jones, Todd K., Grice, Cheryl A.

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Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region von Wiener, John J.M., Wickboldt, Alvah Tyson, Nguyen, Steven, Sun, Siquan, Rynberg, Raymond, Rizzolio, Michele, Karlsson, Lars, Edwards, James P., Grice, Cheryl A.

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Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase von Eccles, Wendy, Blevitt, Jonathan M, Booker, Jamila N, Chrovian, Christa C, Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M, Grice, Cheryl A, Herman, Krystal, Karlsson, Lars, Kearney, Aaron M, Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P, Santillán, Alejandro, Savall, Brad, Tanis, Virginia M, Xue, Xiaohua, Young, Arlene L

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Azabenzthiazole inhibitors of leukotriene A4 hydrolase von Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillán, Alejandro, Wiener, John J.M., Xue, Xiaohua, Young, Arlene L.

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Indole- and benzothiophene-based histamine H3 antagonists von SANTILLAN, Alejandro, MCCLURE, Kelly J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, GRICE, Cheryl A, ALLISON, Brett D, LORD, Brian, BOGGS, Jamin D, MORTON, Kirsten L, EVERSON, Anita M, NEPOMUCENO, Diane, LETAVIC, Michael A, LEE-DUTRA, Alice

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Current status of leukotriene A4 hydrolase inhibitors von Grice, Cheryl A, Gomez, Laurent

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Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors von Wiener, Danielle K., Lee-Dutra, Alice, Bembenek, Scott, Nguyen, Steven, Thurmond, Robin L., Sun, Siquan, Karlsson, Lars, Grice, Cheryl A., Jones, Todd K., Edwards, James P.

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions von Wiener, John J.M., Wickboldt, Alvah T., Wiener, Danielle K., Lee-Dutra, Alice, Edwards, James P., Karlsson, Lars, Nguyen, Steven, Sun, Siquan, Jones, Todd K., Grice, Cheryl A.

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1 von Lee-Dutra, Alice, Wiener, Danielle K., Arienti, Kristen L., Liu, Jing, Mani, Neelakandha, Ameriks, Michael K., Axe, Frank U., Gebauer, Damara, Desai, Pragnya J., Nguyen, Steven, Randal, Mike, Thurmond, Robin L., Sun, Siquan, Karlsson, Lars, Edwards, James P., Jones, Todd K., Grice, Cheryl A.

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Identification of a Potent, Selective, and Orally Active Leukotriene A4 Hydrolase Inhibitor with Anti-Inflammatory Activity von Grice, Cheryl A, Tays, Kevin L, Savall, Brad M, Wei, Jianmei, Butler, Christopher R, Axe, Frank U, Bembenek, Scott D, Fourie, Anne M, Dunford, Paul J, Lundeen, Katherine, Coles, Fawn, Xue, Xiaohua, Riley, Jason P, Williams, Kacy N, Karlsson, Lars, Edwards, James P

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The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors von Grice, Cheryl A., Tays, Kevin, Khatuya, Haripada, Gustin, Darin J., Butler, Christopher R., Wei, Jianmei, Sehon, Clark A., Sun, Siquan, Gu, Yin, Jiang, Wen, Thurmond, Robin L., Karlsson, Lars, Edwards, James P.

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Preparation of oxime dual NK1/NK2 antagonists with reduced NK3 affinity von REICHARD, Gregory A, GRICE, Cheryl A, SHIH, Neng-Yang, SPITLER, James, MAJMUNDAR, Sapna, WANG, Steven D, PALIWAL, Sunil, ANTHES, John C, PIWINSKI, John J

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Synthesis and structure–activity relationships of oxime neurokinin antagonists: discovery of potent arylamides von Shih, Neng-Yang, Albanese, Margaret, Anthes, John C, Carruthers, Nicholas I, Grice, Cheryl A, Lin, Ling, Mangiaracina, Pietro, Reichard, Gregory A, Schwerdt, John, Seidl, Vera, Wong, Shing-Chung, Piwinski, John J

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