MLL fusions: Pathways to leukemia von Liu, Han, Cheng, Emily H.Y., Hsieh, James J.D.

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Biphasic MLL takes helm at cell cycle control: Implications in human mixed lineage leukemia von Liu, Han, Takeda, Shugaku, Cheng, Emily H.Y., Hsieh, James J.D.

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Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis von Kim, Hyungjin, Tu, Ho-Chou, Ren, Decheng, Takeuchi, Osamu, Jeffers, John R., Zambetti, Gerard P., Hsieh, James J.-D., Cheng, Emily H.-Y.

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BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program von Ren, Decheng, Tu, Ho-Chou, Kim, Hyungjin, Wang, Gary X, Bean, Gregory R, Takeuchi, Osamu, Jeffers, John R, Zambetti, Gerard P, Hsieh, James J.-D, Cheng, Emily H.-Y

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BAX activation is initiated at a novel interaction site von Tjandra, Nico, Walensky, Loren D, Gavathiotis, Evripidis, Suzuki, Motoshi, Davis, Marguerite L, Pitter, Kenneth, Bird, Gregory H, Katz, Samuel G, Tu, Ho-Chou, Kim, Hyungjin, Cheng, Emily H.-Y

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies von Cheng, Emily H.-Y, Kim, Hyungjin, Rafiuddin-Shah, Mubina, Tu, Ho-Chou, Jeffers, John R, Zambetti, Gerard P, Hsieh, James J.-D

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Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint von Hsieh, James J.-D, Liu, Han, Takeda, Shugaku, Kumar, Rakesh, Westergard, Todd D, Brown, Eric J, Pandita, Tej K, Cheng, Emily H.-Y

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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis von Emily H. -Y. Cheng, Sheiko, Tatiana V., Fisher, Jill K., Craigen, William J., Korsmeyer, Stanley J.

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Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy von Chen, Yun, Lewis, William, Diwan, Abhinav, Cheng, Emily H.-Y., Matkovich, Scot J., Dorn, Gerald W., Olson, Eric N.

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Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis von Shankar, Thirupura S., Ramadurai, Dinesh K. A., Steinhorst, Kira, Sommakia, Salah, Badolia, Rachit, Thodou Krokidi, Aspasia, Calder, Dallen, Navankasattusas, Sutip, Sander, Paulina, Kwon, Oh Sung, Aravamudhan, Aishwarya, Ling, Jing, Dendorfer, Andreas, Xie, Changmin, Kwon, Ohyun, Cheng, Emily H. Y., Whitehead, Kevin J., Gudermann, Thomas, Richardson, Russel S., Sachse, Frank B., Schredelseker, Johann, Spitzer, Kenneth W., Chaudhuri, Dipayan, Drakos, Stavros G.

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PUMA and BIM are required for oncogene inactivation-induced apoptosis von Bean, Gregory R, Ganesan, Yogesh Tengarai, Dong, Yiyu, Takeda, Shugaku, Liu, Han, Chan, Po M, Huang, Yafen, Chodosh, Lewis A, Zambetti, Gerard P, Hsieh, James J-D, Cheng, Emily H-Y

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis von Cheng, Emily H.-Y.A, Wei, Michael C, Weiler, Solly, Flavell, Richard A, Mak, Tak W, Lindsten, Tullia, Korsmeyer, Stanley J

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A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair von Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana

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Taspase1: A Threonine Aspartase Required for Cleavage of MLL and Proper HOX Gene Expression von Hsieh, James J.-D., Cheng, Emily H.-Y., Korsmeyer, Stanley J.

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p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage von Tu, Ho-Chou, Ren, Decheng, Wang, Gary X, Chen, David Y, Westergard, Todd D, Kim, Hyungjin, Sasagawa, Satoru, Hsieh, James J.-D, Cheng, Emily H.-Y

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Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression von Takeda, Shugaku, Chen, David Y, Westergard, Todd D, Fisher, Jill K, Rubens, Jeffrey A, Sasagawa, Satoru, Kan, Jason T, Korsmeyer, Stanley J, Cheng, Emily H-Y, Hsieh, James J-D

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A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth von CHEN, David Y, LEE, Yishan, OH, Kyoung J, KORSMEYER, Stanley J, HERMONE, Ann, GUSSIO, Richard, SHOEMAKER, Robert H, CHENG, Emily H.-Y, HSIEH, James J.-D, VAN TINE, Brian A, SEARLEMAN, Adam C, WESTERGARD, Todd D, HAN LIU, TU, Ho-Chou, TAKEDA, Shugaku, YIYU DONG, PIWNICA-WORMS, David R

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Conversion of Bcl-2 to a bax-like death effector by caspases von CHENG, E. H.-Y, KIRSCH, D. G, CLEM, R. J, RAVI, R, KASTAN, M. B, BEDI, A, UENO, K, HARDWICK, J. M

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A Novel, High Conductance Channel of Mitochondria Linked to Apoptosis in Mammalian Cells and Bax Expression in Yeast von Pavlov, Evgeny V., Priault, Muriel, Pietkiewicz, Dawn, Emily H.-Y. Cheng, Antonsson, Bruno, Manon, Stephen, Korsmeyer, Stanley J., Mannella, Carmen A., Kinnally, Kathleen W.

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Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis von Chen, David Y, Liu, Han, Takeda, Shugaku, Tu, Ho-Chou, Sasagawa, Satoru, Van Tine, Brian A, Lu, Dongsi, Cheng, Emily H-Y, Hsieh, James J-D

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