Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) von Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K

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Enantioselective Organocatalytic Amine Conjugate Addition von Chen, Young K, Yoshida, Masanori, MacMillan, David W. C

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Catalytic Asymmetric Synthesis of Hydroxy Enol Ethers:  Approach to a Two-Carbon Homologation of Aldehydes von Jeon, Sang-Jin, Chen, Young K, Walsh, Patrick J

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition von Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.

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TACH101, a first-in-class pan-inhibitor of KDM4 for treatment of gastrointestinal cancers von Perabo, Frank, Chandhasin, Chandtip, Yoo, Sanghee, Dang, Van, Del Rosario, Joselyn, Chen, Young K, Stafford, Jeffrey, Quake, Stephen, Clarke, Michael F.

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors von Nie, Zhe, Shi, Lihong, Lai, Chon, Severin, Christophe, Xu, Jiangchun, Del Rosario, Joselyn R., Stansfield, Ryan K., Cho, Robert W., Kanouni, Toufike, Veal, James M., Stafford, Jeffrey A., Chen, Young K.

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models von Chen, Young K, Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R, Hosfield, David J, Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A, Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M, Shi, Lihong, Stafford, Jeffrey A, Stansfield, Ryan K, Veal, James M, Weiss, Michael S, Yuen, Natalie Y, Wallace, Michael B

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A General, Highly Enantioselective Method for the Synthesis of d and l α-Amino Acids and Allylic Amines von Chen, Young K, Lurain, Alice E, Walsh, Patrick J

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One-Pot Multicomponent Coupling Methods for the Synthesis of Diastereo- and Enantioenriched (Z)-Trisubstituted Allylic Alcohols von Kerrigan, Michael H, Jeon, Sang-Jin, Chen, Young K, Salvi, Luca, Carroll, Patrick J, Walsh, Patrick J

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A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols von Chen, Young K, Walsh, Patrick J

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Substrate Dependence of Nonlinear Effects:  Mechanistic Probe and Practical Applications von Chen, Young K, Costa, Anna M, Walsh, Patrick J

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Abstract 2128: TACH101, a first-in-class pan inhibitor of KDM4 histone lysine demethylases von Yoo, Sanghee, Chandhasin, Chandtip, Rosario, Joselyn R. Del, Chen, Young K., Stafford, Jeff, Quake, Stephen, Perabo, Frank, Clarke, Michael F.

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Pharmacologic characterization of TACH101, a first-in-class KDM4 inhibitor for development as a cancer therapeutic von Yoo, Sanghee, Chandhasin, Chandtip, Del Rosario, Joselyn, Chen, Young K, Stafford, Jeffrey, Perabo, Frank, Clarke, Michael F.

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Inhibition of histone lysine demethylases with TACH101, a first-in-class pan-inhibitor of KDM4 von Chandhasin, Chandtip, Yoo, Sanghee, Del Rosario, Joselyn, Chen, Young K, Stafford, Jeffrey, Perabo, Frank, Clarke, Michael F.

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Inhibition of cancer stem cells with TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase von Perabo, Frank, Chandhasin, Chandtip, Dang, Van, Del Rosario, Joselyn, Chen, Young K, Filvaroff, Ellen, Stafford, Jeffrey, Quake, Stephen, Clarke, Michael F.

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Abstract P086: Identification of pharmacodynamic and sensitivity biomarkers for TACH101, a pan-inhibitor of KDM4 histone lysine demethylase von Perabo, Frank, Yoo, Sanghee, Chandhasin, Chandtip, Rosario, Joselyn Del, Chen, Young K., Filvaroff, Ellen, Stafford, Jeffrey A., Quake, Stephen, Clarke, Michael F.

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Abstract 3720: TACH101, a first-in-class inhibitor of KDM4 histone lysine demethylase for the treatment of diffuse large B-cell lymphoma von Perabo, Frank, Chandhasin, Chandtip, Yoo, Sanghee, Rosario, Joselyn Del, Chen, Young K., Filvaroff, Ellen, Stafford, Jeffrey A., Quake, Stephen, Clarke, Michael F.

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Histone demethylase inhibitors von Wallace, Michael Brennan, Chen, Young K

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TREATMENT OF CANCER WITH KDM4 INHIBITORS von CLARKE, Michael, STAFFORD, Jeffrey A, PERABO, Frank, CHEN, Young K

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TREATMENT OF CANCER WITH KDM4 INHIBITORS von CLARKE, Michael, STAFFORD, Jeffrey A, PERABO, Frank, CHEN, Young K

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