The Epigenetic Regulator SMCHD1 in Development and Disease von Jansz, Natasha, Chen, Kelan, Murphy, James M, Blewitt, Marnie E

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FSHD2- and BAMS-associated mutations confer opposing effects on SMCHD1 function von Gurzau, Alexandra D., Chen, Kelan, Xue, Shifeng, Dai, Weiwen, Lucet, Isabelle S., Ly, Thanh Thao Nguyen, Reversade, Bruno, Blewitt, Marnie E., Murphy, James M.

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SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease von Tapia del Fierro, Andres, den Hamer, Bianca, Benetti, Natalia, Jansz, Natasha, Chen, Kelan, Beck, Tamara, Vanyai, Hannah, Gurzau, Alexandra D., Daxinger, Lucia, Xue, Shifeng, Ly, Thanh Thao Nguyen, Wanigasuriya, Iromi, Iminitoff, Megan, Breslin, Kelsey, Oey, Harald, Krom, Yvonne D., van der Hoorn, Dinja, Bouwman, Linde F., Johanson, Timothy M., Ritchie, Matthew E., Gouil, Quentin A., Reversade, Bruno, Prin, Fabrice, Mohun, Timothy, van der Maarel, Silvère M., McGlinn, Edwina, Murphy, James M., Keniry, Andrew, de Greef, Jessica C., Blewitt, Marnie E.

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Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation von Chen, Kelan, Jiang Hu, Darcy L. Moore, Ruijie Liu, Sarah A. Kessans, Kelsey Breslin, Isabelle S. Lucet, Andrew Keniry, Huei San Leong, Clare L. Parish, Douglas J. Hilton, Richard J. L. F. Lemmers, Silvère M. van der Maarel, Peter E. Czabotar, Renwick C. J. Dobson, Matthew E. Ritchie, Graham F. Kay, James M. Murphy, Marnie E. Blewitt

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Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues von Chen, Kelan, Birkinshaw, Richard W, Gurzau, Alexandra D, Wanigasuriya, Iromi, Wang, Ruoyun, Iminitoff, Megan, Sandow, Jarrod J, Young, Samuel N, Hennessy, Patrick J, Willson, Tracy A, Heckmann, Denise A, Webb, Andrew I, Blewitt, Marnie E, Czabotar, Peter E, Murphy, James M

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The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain von Chen, Kelan, Dobson, Renwick C J, Lucet, Isabelle S, Young, Samuel N, Pearce, F Grant, Blewitt, Marnie E, Murphy, James M

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Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor von HUEI SAN LEONG, KELAN CHEN, HILTON, Douglas J, BLEWITT, Marnie E, YIFANG HU, LEE, Stanley, CORBIN, Jason, PAKUSCH, Miha, MURPHY, James M, MAJEWSKI, Ian J, SMYTH, Gordon K, ALEXANDER, Warren S

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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing von Keniry, Andrew, Gearing, Linden J, Jansz, Natasha, Liu, Joy, Holik, Aliaksei Z, Hickey, Peter F, Kinkel, Sarah A, Moore, Darcy L, Breslin, Kelsey, Chen, Kelan, Liu, Ruijie, Phillips, Catherine, Pakusch, Miha, Biben, Christine, Sheridan, Julie M, Kile, Benjamin T, Carmichael, Catherine, Ritchie, Matthew E, Hilton, Douglas J, Blewitt, Marnie E

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Transcriptional profiling of the epigenetic regulator Smchd1 von Liu, Ruijie, Chen, Kelan, Jansz, Natasha, Blewitt, Marnie E., Ritchie, Matthew E.

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Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses von Liu, Ruijie, Holik, Aliaksei Z, Su, Shian, Jansz, Natasha, Chen, Kelan, Leong, Huei San, Blewitt, Marnie E, Asselin-Labat, Marie-Liesse, Smyth, Gordon K, Ritchie, Matthew E

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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties von Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S

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An optimized SEC‐SAXS system enabling high X‐ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis von Ryan, Timothy M., Trewhella, Jill, Murphy, James M., Keown, Jeremy R., Casey, Lachlan, Pearce, F. Grant, Goldstone, David C., Chen, Kelan, Luo, Zhenyao, Kobe, Bostjan, McDevitt, Christopher A., Watkin, Serena A., Hawley, Adrian M., Mudie, Stephen T., Samardzic Boban, Vesna, Kirby, Nigel

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Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2 von Kinkel, Sarah A., Galeev, Roman, Flensburg, Christoffer, Keniry, Andrew, Breslin, Kelsey, Gilan, Omer, Lee, Stanley, Liu, Joy, Chen, Kelan, Gearing, Linden J., Moore, Darcy L., Alexander, Warren S., Dawson, Mark, Majewski, Ian J., Oshlack, Alicia, Larsson, Jonas, Blewitt, Marnie E.

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The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration von Chen, Kelan, Czabotar, Peter E, Blewitt, Marnie E, Murphy, James M

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Abstract 4260: PT886, an anti-claudin18.2/anti-CD47 bispecific antibody constructed with the PACbody࣪ and SPECpair࣪ technology platforms, exhibits robust anti-tumor activity in a p... von Li, Jack, Jia, Haiqun, Ramsey, Erin, Wu, Huiwen, Long, Yang, Chen, Kelan, Lam, Albert, Wang, Ming, Zou, Hui

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Abstract 4259: PT199, a next generation anti-CD73 mAb that inhibits both membrane-bound and soluble CD73 activity to completion without “hook effect” von Jia, Haiqun (John), Li, Jack, Pei, Fen, Greenwood, Lorraine, Pejza, Lauren, Long, Yan, Chen, Kelan, Perer, Jessica, Wang, Ming, Zou, Hui

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Abstract 2908: PT217, an anti-DLL3/anti-CD47 bispecific antibody, exhibits anti-tumor activity through novel mechanisms of action von Jia, Haiqun(John), Fang, Dorthy, Lobsinger, Molly, Long, Yan, Chen, Kelan, Lam, Albert, Guo, Yangyang, Selesniemi, Kaisa, Wang, Ming, Zou, Hui

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Ihstone H3 lysine 9 methylation is involved not only in maintaining epigenetic silencing, but is essential for setting up gene silencing von Keniry, Andrew, Gearing, Linden, Jansz, Natasha, Liu, Joy, Kinkel, Sarah, Breslin, Kelsey, Moore, Darcy, Chen, Kelan, Pakusch, Miha, Willson, Tracy, Kile, Benjamin, Carmichael, Catherine, Ritchie, Matthew, Hilton, Douglas, Blewitt, Marnie E

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Ultrasonic examination auxiliary device von CHEN KELAN, BIAN WENBING

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Mixer for preparing energy-saving environment-friendly organic anti-corrosion modified wood production medicament von LIAN YUHE, LIN JIANHANG, CHEN KELAN, LIU PINGPING

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