Exploring IDP-Ligand Interactions: tau K18 as A Test Case von Vagrys, Darius, Davidson, James, Chen, Ijen, Hubbard, Roderick E, Davis, Ben

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Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl‑2 and Mcl‑1 von Murray, James B, Davidson, James, Chen, Ijen, Davis, Ben, Dokurno, Pawel, Graham, Christopher J, Harris, Richard, Jordan, Allan, Matassova, Natalia, Pedder, Christopher, Ray, Stuart, Roughley, Stephen D, Smith, Julia, Walmsley, Claire, Wang, Yikang, Whitehead, Neil, Williamson, Douglas S, Casara, Patrick, Le Diguarher, Thierry, Hickman, John, Stark, Jerome, Kotschy, András, Geneste, Olivier, Hubbard, Roderick E

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The Effect of Core Replacement on S64315, a Selective MCL‑1 Inhibitor, and Its Analogues von Sipos, Szabolcs, Bálint, Balázs, Szabó, Zoltán B, Ondi, Levente, Csékei, Márton, Szlávik, Zoltán, Proszenyák, Ágnes, Murray, James B, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Pedder, Christopher, Hubbard, Roderick E, Maragno, Ana-Leticia, Chanrion, Maia, Colland, Frederic, Geneste, Olivier, Kotschy, András

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Identification and Characterization of Small Molecule Inhibitors of the Calcium-Dependent S100B−p53 Tumor Suppressor Interaction von Markowitz, Joseph, Chen, Ijen, Gitti, Rossi, Baldisseri, Donna M, Pan, Yongping, Udan, Ryan, Carrier, France, MacKerell, Alexander D, Weber, David J

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models von Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier

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Discovery of S64315, a Potent and Selective Mcl‑1 Inhibitor von Szlavik, Zoltan, Csekei, Marton, Paczal, Attila, Szabo, Zoltan B, Sipos, Szabolcs, Radics, Gabor, Proszenyak, Agnes, Balint, Balazs, Murray, James, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Daniels, Zoe Marie, Hubbard, Roderick E, Le Toumelin-Braizat, Gaëtane, Claperon, Audrey, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Bruno, Alain, Chanrion, Maia, Colland, Frédéric, Maragno, Ana-Leticia, Demarles, Didier, Geneste, Olivier, Kotschy, Andras

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Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential von Peter, Sonja, Siragusa, Lydia, Thomas, Morgan, Palomba, Tommaso, Cross, Simon, O’Boyle, Noel M., Bajusz, Dávid, Ferenczy, György G., Keserű, György M., Bottegoni, Giovanni, Bender, Brian, Chen, Ijen, De Graaf, Chris

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Structure-Guided Discovery of a Selective Mcl‑1 Inhibitor with Cellular Activity von Szlávik, Zoltan, Ondi, Levente, Csékei, Márton, Paczal, Attila, Szabó, Zoltán B, Radics, Gábor, Murray, James, Davidson, James, Chen, Ijen, Davis, Ben, Hubbard, Roderick E, Pedder, Christopher, Dokurno, Pawel, Surgenor, Allan, Smith, Julia, Robertson, Alan, LeToumelin-Braizat, Gaetane, Cauquil, Nicolas, Zarka, Marion, Demarles, Didier, Perron-Sierra, Francoise, Claperon, Audrey, Colland, Frederic, Geneste, Olivier, Kotschy, András

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S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth von Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J S, Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A, Morris, Erick, Murray, James, Geneste, Olivier

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Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax von Tiran, Arnaud Le, Claperon, Audrey, Davidson, James, Starck, Jérôme-Benoit, Diguarher, Thierry Le, Chanrion, Maïa, Mistry, Prakash, Wang, Youzhen, Monceau, Elodie, Bernhardt, Fabienne, Rocchetti, Francesca, Lysiak-Auvity, Gaelle, Chen, Ijen, Daniels, Zoe, Pedder, Chris, Fallowfield, Mandy, Henlin, Jean-Michel, Fejes, Imre, Tatai, Janos, Nyerges, Miklos, Durand, Didier, Zarka, Marion, Sanghavi, Sneha, Girard, Anne-Marie, Schoumacher, Marie, Kraus-Berthier, Laurence, Newcombe, Rick, Halilovic, Ensar, Banquet, Sébastien, Rupin, Alain, Maacke, Heiko, Murray, James, Morris, Erick, Hofmann, Francesco, Colland, Frédéric, Geneste, Olivier

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Abstract 4482: S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models von Maragno, Ana Leticia, Mistry, Prakash, Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Toumelin-Braizat, Gaëtane Le, Chanrion, Maïa, Bruno, Alain, Claperon, Audrey, Maacke, Heiko, Morris, Erick, Wang, Youzhen, Derreal, Alix, Csekei, Márton, Paczal, Attila, Szabo, Zoltán, Sipos, Szabolcs, Proszenyak, Agnes, Balint, Balázs, Surgenor, Allan, Dokurno, Pawel, Matassova, Natalia, Chen, Ijen, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Grave, Fabienne, Colland, Frédéric, Halilovic, Ensar, Geneste, Olivier

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Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity von Geneste, Olivier, Murray, James, Diguarher, Thierry Le, Starck, Jérome, Casara, Patrick, Nanteuil, Guillaume De, Davidson, James, Nunns, Claire, Graham, Chris, Matassova, Natalia, Chen, Ijen, Whitehead, Neil, Dokurno, Pawel, Bruno, Alain, Pierré, Alain, Hickman, John. A., Wood, Mike, Cruzalegui, Francisco, Depil, Stéphane

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Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor von BEDFORD, Simon T, BENWELL, Karen R, KLENKE, Burkhard, LESTRAT, Loic, MERRETT, Angela, MISRA, Anil, LIGHTOWLER, Sean, PADFIELD, Anthony, POULLENNEC, Karine, REECE, Mark, SIMMONITE, Heather, WONG, Melanie, BROOKS, Teresa, YULE, Ian A, CHEN, Ijen, COMER, Mike, DUGDALE, Sarah, HAYMES, Tim, JORDAN, Allan M, KENNETT, Guy A, KNIGHT, Anthony R

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Discovery and optimization of potent and selective functional antagonists of the human adenosine A sub(2B) receptor von Bedford, Simon T, Benwell, Karen R, Brooks, Teresa, Chen, Ijen, Comer, Mike, Dugdale, Sarah, Haymes, Tim, Jordan, Allan M, Kennett, Guy A, Knight, Anthony R, Klenke, Burkhard, LeStrat, Loic, Merrett, Angela, Misra, Anil, Lightowler, Sean, Padfield, Anthony, Poullennec, Karine, Reece, Mark, Simmonite, Heather, Wong, Melanie, Yule, Ian A

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Discovery and optimization of potent and selective functional antagonists of the human adenosine A 2B receptor von Bedford, Simon T., Benwell, Karen R., Brooks, Teresa, Chen, Ijen, Comer, Mike, Dugdale, Sarah, Haymes, Tim, Jordan, Allan M., Kennett, Guy A., Knight, Anthony R., Klenke, Burkhard, LeStrat, Loic, Merrett, Angela, Misra, Anil, Lightowler, Sean, Padfield, Anthony, Poullennec, Karine, Reece, Mark, Simmonite, Heather, Wong, Melanie, Yule, Ian A.

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Exploring idp–ligand interactions:Tau k18 as a test case von Vagrys, Darius, Davidson, James, Chen, Ijen, Hubbard, Roderick E, Davis, Ben

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Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1 von Murray, James B, Davidson, James, Chen, Ijen, Davis, Ben, Dokurno, Pawel, Graham, Christopher J, Harris, Richard, Jordan, Allan, Matassova, Natalia, Pedder, Christopher, Ray, Stuart, Roughley, Stephen D, Smith, Julia, Walmsley, Claire, Wang, Yikang, Whitehead, Neil, Williamson, Douglas S, Casara, Patrick, Le Diguarher, Thierry, Hickman, John, Stark, Jerome, Kotschy, András, Geneste, Olivier, Hubbard, Roderick E

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S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth von Casara, Patrick, Davidson, James, Claperon, Audrey, Toumelin-Braizat, Gaëtane Le, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Diguarher, Thierry Le, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Franscesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Gouill, Steven Le, Dyer, Martin JS, Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A, Morris, Erick, Murray, James, Geneste, Olivier

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PYRAZINE DERIVATIVES AND THEIR USE IN THERAPY von DRYSDALE, MARTIN JAMES, WALMSLEY, LEE DAVID, CHEN, IJEN

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Investigation of Geometric Effect Impact on SONOS Memory in a NAND Array Structure von KU, Shaw-Hung, CHEN, Kuan-Fu, LU, Wen-Pin, CHEN, Kuang-Chao, LU, Chih-Yuan, CHONG, Lit-Ho, CHEN, Yin-Jen, YEH, Teng-Hao, LIN, Shang-Wei, HAN, Tzung-Ting, ZOUS, Nian-Kai, HUANG, Ijen, CHEN, Ming-Shiang

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