New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation von Lam, Patrick Y.S, Clark, Charles G, Saubern, Simon, Adams, Jessica, Winters, Michael P, Chan, Dominic M.T, Combs, Andrew

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a... von Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R

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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase von Shaw, Scott A., Vokits, Benjamin P., Dilger, Andrew K., Viet, Andrew, Clark, Charles G., Abell, Lynn M., Locke, Gregory A., Duke, Gerald, Kopcho, Lisa M., Dongre, Ashok, Gao, Ji, Krishnakumar, Arathi, Jusuf, Sutjano, Khan, Javed, Spronk, Steven A., Basso, Michael D., Zhao, Lei, Cantor, Glenn H., Onorato, Joelle M., Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.

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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species von Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Corte, James R, Fang, Tianan, Gilligan, Paul J, Jeon, Yoon, Pabbisetty, Kumar B, Rampulla, Richard A, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Arumugam, Arunachalam, Raju, Sivashankaran, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Chacko, Silvi A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl J, Wong, Pancras C, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R

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Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups von Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R

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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability von Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.

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Copper-promoted/catalyzed CN and CO bond cross-coupling with vinylboronic acid and its utilities von Lam, Patrick Y.S, Vincent, Guillaume, Bonne, Damien, Clark, Charles G

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Copper-catalyzed general CN and CO bond cross-coupling with arylboronic acid von Lam, Patrick Y.S, Vincent, Guillaume, Clark, Charles G, Deudon, Sophie, Jadhav, Prabhakar K

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Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library von Lam, Patrick Y.S., Adams, Jessica J., Clark, Charles G., Calhoun, W.Jason, Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R.

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N-Arylation of α-aminoesters with p-tolylboronic acid promoted by copper(II) acetate von Lam, Patrick Y.S, Bonne, Damien, Vincent, Guillaume, Clark, Charles G, Combs, Andrew P

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Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent... von Jeon, Yoon T, Yang, Wu, Qiao, Jennifer X, Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C, Wang, Yufeng, Liu, Yajun, Clark, Charles G, Wong, Henry S, Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A, Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S, Schumacher, William A, Bostwick, Jeffrey S, Stewart, Anne B, Price, Laura A, Hua, Ji, Li, Danshi, Levesque, Paul C, Seiffert, Dietmar A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y S

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Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility von Wang, Tammy C, Qiao, Jennifer X, Clark, Charles G, Jua, Ji, Price, Laura A, Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S, Everlof, Gerry, Schumacher, William A, Wong, Pancras C, Seiffert, Dietmar A, Stewart, Anne B, Bostwick, Jeffrey S, Crain, Earl J, Watson, Carol A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y S

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Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility von Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

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4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution von Qiao, Jennifer X., Wang, Tammy C., Hiebert, Sheldon, Hu, Carol H., Schumacher, William A., Spronk, Steven A., Clark, Charles G., Han, Ying, Hua, Ji, Price, Laura A., Shen, Hong, Chacko, Silvi A., Everlof, Gerry, Bostwick, Jeffrey S., Steinbacher, Thomas E., Li, Yi-Xin, Huang, Christine S., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants von Lam, Patrick Y. S, Clark, Charles G, Li, Renhua, Pinto, Donald J. P, Orwat, Michael J, Galemmo, Robert A, Fevig, John M, Teleha, Christopher A, Alexander, Richard S, Smallwood, Angela M, Rossi, Karen A, Wright, Matthew R, Bai, Stephen A, He, Kan, Luettgen, Joseph M, Wong, Pancras C, Knabb, Robert M, Wexler, Ruth R

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α-Nitrogen activating effect in the room temperature copper-promoted N-arylation of heteroarylcarboxamides with phenyl siloxane or p-toluylboronic acid von Lam, Patrick Y.S, Deudon, Sophie, Hauptman, Elisabeth, Clark, Charles G

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Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids von Jayaraj, A Paul, Tovey, Frank I, Lewin, Michael R, Clark, Charles G

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Copper promoted CN and CO bond cross-coupling with phenyl and pyridylboronates von Chan, Dominic M.T., Monaco, Kevin L., Li, Renhua, Bonne, Damien, Clark, Charles G., Lam, Patrick Y.S.

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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent... von Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

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Copper-Promoted C−N Bond Cross-Coupling with Hypervalent Aryl Siloxanes and Room-Temperature N-Arylation with Aryl Iodide von Lam, Patrick Y. S., Deudon, Sophie, Averill, Kristin M., Li, Renhua, He, Ming Y., DeShong, Philip, Clark, Charles G.

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