National Institutes of Health Blueprint Neurotherapeutics Network: Results to Date and Path Forward von Cywin, Charles L., Tamiz, Amir P.

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Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Diseas... von Cioffi, Christopher L, Dobri, Nicoleta, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Golden, Kathy C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin

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Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease von Cioffi, Christopher L, Racz, Boglarka, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin

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Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode von Qian, Kevin, Wang, Lian, Cywin, Charles L, Farmer, Bennett T, Hickey, Eugene, Homon, Carol, Jakes, Scott, Kashem, Mohammed A, Lee, George, Leonard, Scott, Li, Jun, Magboo, Ronald, Mao, Wang, Pack, Edward, Peng, Charlene, Prokopowicz, Anthony, Welzel, Morgan, Wolak, John, Morwick, Tina

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Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β:  Part I:  Hit-to-Lead Strategies von Morwick, Tina, Berry, Angela, Brickwood, Janice, Cardozo, Mario, Catron, Katrina, DeTuri, Molly, Emeigh, Jonathan, Homon, Carol, Hrapchak, Matt, Jacober, Stephen, Jakes, Scott, Kaplita, Paul, Kelly, Terence A, Ksiazek, John, Liuzzi, Michel, Magolda, Ronald, Mao, Can, Marshall, Daniel, McNeil, Daniel, Prokopowicz, Anthony, Sarko, Christopher, Scouten, Erika, Sledziona, Cynthia, Sun, Sanxing, Watrous, Jane, Wu, Jiang Ping, Cywin, Charles L

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Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors von Snow, Roger J., Abeywardane, Asitha, Campbell, Scot, Lord, John, Kashem, Mohammed A., Khine, Hnin Hnin, King, Josephine, Kowalski, Jennifer A., Pullen, Steven S., Roma, Teresa, Roth, Gregory P., Sarko, Christopher R., Wilson, Noel S., Winters, Michael P., Wolak, John P., Cywin, Charles L.

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Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method von Kowalski, Jennifer A., Swinamer, Alan D., Muegge, Ingo, Eldrup, Anne B., Kukulka, Alison, Cywin, Charles L., De Lombaert, Stéphane

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Discovery of potent and selective PKC-θ inhibitors von Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

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Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account von Wu, Frank, Büttner, Frank H., Chen, Rhonda, Hickey, Eugene, Jakes, Scott, Kaplita, Paul, Kashem, Mohammed A., Kerr, Steven, Kugler, Stanley, Paw, Zofia, Prokopowicz, Anthony, Shih, Cheng-Kon, Snow, Roger, Young, Erick, Cywin, Charles L.

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Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats von GINN, John D, BOSANAC, Todd, SCHLYER, Sabine, SMITH, James D, TURNER, Michael R, WU, Frank, YOUNG, Erick R. R, CHEN, Rhonda, CYWIN, Charles, HICKEY, Eugene, KASHEM, Mohammed, KERR, Steven, KUGLER, Stanley, XIANG LI, PROKOPOWICZ, Anthony

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Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase von Morwick, Tina, Büttner, Frank H, Cywin, Charles L, Dahmann, Georg, Hickey, Eugene, Jakes, Scott, Kaplita, Paul, Kashem, Mohammed A, Kerr, Steven, Kugler, Stanley, Mao, Wang, Marshall, Daniel, Paw, Zofia, Shih, Cheng-Kon, Wu, Frank, Young, Erick

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors von Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk) von Winters, Michael P, Robinson, Darius J, Khine, Hnin Hnin, Pullen, Steven S, Woska, Jr, Joseph R, Raymond, Ernest L, Sellati, Rosemarie, Cywin, Charles L, Snow, Roger J, Kashem, Mohammed A, Wolak, John P, King, Josephine, Kaplita, Paul V, Liu, Lisa H, Farrell, Thomas M, DesJarlais, Renee, Roth, Gregory P, Takahashi, Hidenori, Moriarty, Kevin J

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NINDS funding opportunities for Alzheimer’s Disease‐Related Dementia therapy development von Roof, Rebecca, Mcgavern, Linda, Boshoff, Chris, Lavaute, Timothy, Cywin, Charles, Thomas, Shruthi, McCartney, Amber J, Corriveau, Roderick A

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Developing Topics von Roof, Rebecca, Mcgavern, Linda, Boshoff, Chris, Lavaute, Timothy, Cywin, Charles, Thomas, Shruthi, McCartney, Amber J, Corriveau, Roderick A

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket von Tong, Liang, Pav, Susan, White, Della M, Rogers, Sheri, Crane, Kathy M, Cywin, Charles L, Brown, Maryanne L, Pargellis, Christopher A

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Effect of Structural Modification of Enol−Carboxamide-Type Nonsteroidal Antiinflammatory Drugs on COX-2/COX-1 Selectivity von Lazer, Edward S, Miao, Clara K, Cywin, Charles L, Sorcek, Ronald, Wong, Hin-Chor, Meng, Zhaoxing, Potocki, Ian, Hoermann, MaryAnn, Snow, Roger J, Tschantz, Matt A, Kelly, Terence A, McNeil, Daniel W, Coutts, Simon J, Churchill, Laurie, Graham, Anne G, David, Eva, Grob, Peter M, Engel, Wolfhard, Meier, Hans, Trummlitz, Günter

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Discovery and SAR of novel [1,6]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK) von Cywin, Charles L, Zhao, Bao-Ping, McNeil, Daniel W, Hrapchak, Matt, Prokopowicz, Anthony S, Goldberg, Daniel R, Morwick, Tina M, Gao, Amy, Jakes, Scott, Kashem, Mohammed, Magolda, Ronald L, Soll, Richard M, Player, Mark R, Bobko, Mark A, Rinker, James, DesJarlais, Renee L, Winters, Michael P

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An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity von Desai, Sudha N., White, Della M., O'Shea, Kathryn M., Brown, Maryanne L., Cywin, Charles L., Spero, Denice M., Panzenbeck, Maret J.

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The design of potent hydrazones and disulfides as cathepsin S inhibitors von Cywin, Charles L, Firestone, Raymond A, McNeil, Daniel W, Grygon, Christine A, Crane, Kathryn M, White, Della M, Kinkade, Peter R, Hopkins, Jerry L, Davidson, Walter, Labadia, Mark E, Wildeson, Jessi, Morelock, Maurice M, Peterson, Jeffrey D, Raymond, Ernest L, Brown, Maryanne L, Spero, Denice M

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