A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer von CHANRION, Maïa, NEGRE, Vincent, DARBON, Jean-Marie, FONTAINE, Hélène, SALVETAT, Nicolas, BIBEAU, Frederic, GROGAN, Gaëtan Mac, MAURIAC, Louis, KATSAROS, Dionyssios, MOLINA, Franck, THEILLET, Charles

Volltext

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models von Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier

Volltext

CIP2A Is Associated with Human Breast Cancer Aggressivity von COME, Christophe, LAINE, Anni, KALLIONIEMI, Olli, THEZENAS, Simon, WESTERMARCK, Jukka, CHANRION, Maïa, EDGREN, Henrik, MATTILA, Elina, XIAOLING LIU, JONKERS, Jos, IVASKA, Johanna, ISOLA, Jorma, DARBON, Jean-Marie

Volltext

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia von Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.

Volltext

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening von Sawey, Eric T., Chanrion, Maia, Cai, Chunlin, Wu, Guanming, Zhang, Jianping, Zender, Lars, Zhao, Alice, Busuttil, Ronald W., Yee, Herman, Stein, Lincoln, French, Dorothy M., Finn, Richard S., Lowe, Scott W., Powers, Scott

Volltext

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut von Chanrion, Maia, Kuperstein, Inna, Barrière, Cédric, El Marjou, Fatima, Cohen, David, Vignjevic, Danijela, Stimmer, Lev, Paul-Gilloteaux, Perrine, Bièche, Ivan, Tavares, Silvina Dos Reis, Boccia, Giuseppe-Fulvio, Cacheux, Wulfran, Meseure, Didier, Fre, Silvia, Martignetti, Loredana, Legoix-Né, Patricia, Girard, Elodie, Fetler, Luc, Barillot, Emmanuel, Louvard, Daniel, Zinovyev, Andreï, Robine, Sylvie

Volltext

The Transcriptional Coregulator RIP140 Represses E2F1 Activity and Discriminates Breast Cancer Subtypes von DOCQUIER, Aurélie, HARMAND, Pierre-Olivier, FRITSCH, Samuel, CHANRION, Maïa, DARBON, Jean-Marie, CAVAILLES, Vincent

Volltext

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL von Moujalled, Donia M., Hanna, Diane T., Hediyeh-zadeh, Soroor, Pomilio, Giovanna, Brown, Lauren, Litalien, Veronique, Bartolo, Ray, Fleming, Shaun, Chanrion, Maïa, Banquet, Sébastien, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Schoumacher, Marie, Mullighan, Charles G., Georgiou, Angela, White, Christine A., Lessene, Guillaume, Huang, David C.S., Roberts, Andrew W., Geneste, Olivier, Rasmussen, Lorna, Davis, Melissa J., Ekert, Paul G., Wei, Andrew, Ng, Ashley P., Khaw, Seong L.

Volltext

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth von Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J S, Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A, Morris, Erick, Murray, James, Geneste, Olivier

Volltext

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma von Li, Jinyu, Chanrion, Maia, Sawey, Eric, Wang, Tim, Chow, Edward, Tward, Aaron, Su, Yi, Xue, Wen, Lucito, Robert, Zender, Lars, Lowe, Scott W, Bishop, J Michael, Powers, Scott

Volltext

Abstract 257: Targeting AML through apoptosis activation using Bcl-2/Mcl-1 or Bcl-2/Hdm2 inhibitor combination therapies von Wang, Youzhen, Qui, Shumei, Sanghavi, Sneha, Mulford, Iain, Lysiak, Gaëlle, Chanrion, Maïa, Mistry, Prakash, Pfaar, Ulrike, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fabre, Claire, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Halilovic, Ensar

Volltext

Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax von Tiran, Arnaud Le, Claperon, Audrey, Davidson, James, Starck, Jérôme-Benoit, Diguarher, Thierry Le, Chanrion, Maïa, Mistry, Prakash, Wang, Youzhen, Monceau, Elodie, Bernhardt, Fabienne, Rocchetti, Francesca, Lysiak-Auvity, Gaelle, Chen, Ijen, Daniels, Zoe, Pedder, Chris, Fallowfield, Mandy, Henlin, Jean-Michel, Fejes, Imre, Tatai, Janos, Nyerges, Miklos, Durand, Didier, Zarka, Marion, Sanghavi, Sneha, Girard, Anne-Marie, Schoumacher, Marie, Kraus-Berthier, Laurence, Newcombe, Rick, Halilovic, Ensar, Banquet, Sébastien, Rupin, Alain, Maacke, Heiko, Murray, James, Morris, Erick, Hofmann, Francesco, Colland, Frédéric, Geneste, Olivier

Volltext

A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study von Chanrion, Maïa, Fontaine, Hélène, Rodriguez, Carmen, Negre, Vincent, Bibeau, Frédéric, Theillet, Charles, Hénaut, Alain, Darbon, Jean-Marie

Volltext

Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies von Halilovic, Ensar, Chanrion, Maïa, Mistry, Prakash, Wartmann, Markus, Qiu, Shumei, Sanghavi, Sneha, Chen, Yan, Lysiak, Gaëlle, Maragno, Ana Leticia, Pfaar, Ulrike, Huth, Felix, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Wang, Youzhen

Volltext

Abstract 4482: S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models von Maragno, Ana Leticia, Mistry, Prakash, Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Toumelin-Braizat, Gaëtane Le, Chanrion, Maïa, Bruno, Alain, Claperon, Audrey, Maacke, Heiko, Morris, Erick, Wang, Youzhen, Derreal, Alix, Csekei, Márton, Paczal, Attila, Szabo, Zoltán, Sipos, Szabolcs, Proszenyak, Agnes, Balint, Balázs, Surgenor, Allan, Dokurno, Pawel, Matassova, Natalia, Chen, Ijen, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Grave, Fabienne, Colland, Frédéric, Halilovic, Ensar, Geneste, Olivier

Volltext

The Effect of Core Replacement on S64315, a Selective MCL‑1 Inhibitor, and Its Analogues von Sipos, Szabolcs, Bálint, Balázs, Szabó, Zoltán B, Ondi, Levente, Csékei, Márton, Szlávik, Zoltán, Proszenyák, Ágnes, Murray, James B, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Pedder, Christopher, Hubbard, Roderick E, Maragno, Ana-Leticia, Chanrion, Maia, Colland, Frederic, Geneste, Olivier, Kotschy, András

Volltext

Discovery of S64315, a Potent and Selective Mcl‑1 Inhibitor von Szlavik, Zoltan, Csekei, Marton, Paczal, Attila, Szabo, Zoltan B, Sipos, Szabolcs, Radics, Gabor, Proszenyak, Agnes, Balint, Balazs, Murray, James, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Daniels, Zoe Marie, Hubbard, Roderick E, Le Toumelin-Braizat, Gaëtane, Claperon, Audrey, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Bruno, Alain, Chanrion, Maia, Colland, Frédéric, Maragno, Ana-Leticia, Demarles, Didier, Geneste, Olivier, Kotschy, Andras

Volltext

Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity von Vasas, Attila, Ivanschitz, Lisa, Molnár, Balázs, Kiss, Árpád, Baker, Lisa, Fiumana, Andrea, Macias, Alba, Murray, James B., Sanders, Emma, Whitehead, Neil, Hubbard, Roderick E., Saunier, Carine, Monceau, Elodie, Girard, Anne Marie, Rousseau, Marion, Chanrion, Maia, Demarles, Didier, Geneste, Olivier, Weber, Csaba, Lewkowicz, Elodie, Kotschy, Andras

Volltext

Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia von Moujalled, Donia M, Brown, Fiona C, Pomilio, Giovanna, Anstee, Natasha S, Litalien, Veronique, Thompson, Ella R, Morley, Thomas, MacRaild, Sarah, Chua, Chong C, Banquet, SéBastien, Chanrion, Maia, Maragno, Ana-Leticia, Schoumacher, Marie, Herold, Marco J, Lessene, Guillaume, Geneste, Olivier, Huang, David C.S., Roberts, Andrew W, Blombery, Piers, Wei, Andrew

Volltext

Abstract 5015: Innovative and predictive models against breast cancer von Duchamp, Olivier, Tabone-Eglinger, Severine, Mignard, Caroline, Goddard, Isabelle, Bruno, Alain, Chanrion, Maia, Calvet, Loreley, Degoul, Olivier, Dhondt, Kevin, Goetsch, Liliane, Miralves, Julie, Lautrette, Christophe, Pensec, Cindy, Vacon, Françoise Le, Treilleux, Isabelle, Arnould, Laurent, Vaglio, Philippe, Prevost, Grégoire, Tredan, Olivier

Volltext