The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models von Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier

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CIP2A Is Associated with Human Breast Cancer Aggressivity von COME, Christophe, LAINE, Anni, KALLIONIEMI, Olli, THEZENAS, Simon, WESTERMARCK, Jukka, CHANRION, Maïa, EDGREN, Henrik, MATTILA, Elina, XIAOLING LIU, JONKERS, Jos, IVASKA, Johanna, ISOLA, Jorma, DARBON, Jean-Marie

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Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia von Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.

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Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening von Sawey, Eric T., Chanrion, Maia, Cai, Chunlin, Wu, Guanming, Zhang, Jianping, Zender, Lars, Zhao, Alice, Busuttil, Ronald W., Yee, Herman, Stein, Lincoln, French, Dorothy M., Finn, Richard S., Lowe, Scott W., Powers, Scott

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A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer von CHANRION, Maïa, NEGRE, Vincent, DARBON, Jean-Marie, FONTAINE, Hélène, SALVETAT, Nicolas, BIBEAU, Frederic, GROGAN, Gaëtan Mac, MAURIAC, Louis, KATSAROS, Dionyssios, MOLINA, Franck, THEILLET, Charles

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Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut von Chanrion, Maia, Kuperstein, Inna, Barrière, Cédric, El Marjou, Fatima, Cohen, David, Vignjevic, Danijela, Stimmer, Lev, Paul-Gilloteaux, Perrine, Bièche, Ivan, Tavares, Silvina Dos Reis, Boccia, Giuseppe-Fulvio, Cacheux, Wulfran, Meseure, Didier, Fre, Silvia, Martignetti, Loredana, Legoix-Né, Patricia, Girard, Elodie, Fetler, Luc, Barillot, Emmanuel, Louvard, Daniel, Zinovyev, Andreï, Robine, Sylvie

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The Transcriptional Coregulator RIP140 Represses E2F1 Activity and Discriminates Breast Cancer Subtypes von DOCQUIER, Aurélie, HARMAND, Pierre-Olivier, FRITSCH, Samuel, CHANRION, Maïa, DARBON, Jean-Marie, CAVAILLES, Vincent

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Cotargeting BCL-2 and MCL-1 in high-risk B-ALL von Moujalled, Donia M., Hanna, Diane T., Hediyeh-zadeh, Soroor, Pomilio, Giovanna, Brown, Lauren, Litalien, Veronique, Bartolo, Ray, Fleming, Shaun, Chanrion, Maïa, Banquet, Sébastien, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Schoumacher, Marie, Mullighan, Charles G., Georgiou, Angela, White, Christine A., Lessene, Guillaume, Huang, David C.S., Roberts, Andrew W., Geneste, Olivier, Rasmussen, Lorna, Davis, Melissa J., Ekert, Paul G., Wei, Andrew, Ng, Ashley P., Khaw, Seong L.

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Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma von Li, Jinyu, Chanrion, Maia, Sawey, Eric, Wang, Tim, Chow, Edward, Tward, Aaron, Su, Yi, Xue, Wen, Lucito, Robert, Zender, Lars, Lowe, Scott W, Bishop, J Michael, Powers, Scott

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The Effect of Core Replacement on S64315, a Selective MCL‑1 Inhibitor, and Its Analogues von Sipos, Szabolcs, Bálint, Balázs, Szabó, Zoltán B, Ondi, Levente, Csékei, Márton, Szlávik, Zoltán, Proszenyák, Ágnes, Murray, James B, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Pedder, Christopher, Hubbard, Roderick E, Maragno, Ana-Leticia, Chanrion, Maia, Colland, Frederic, Geneste, Olivier, Kotschy, András

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A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study von Chanrion, Maïa, Fontaine, Hélène, Rodriguez, Carmen, Negre, Vincent, Bibeau, Frédéric, Theillet, Charles, Hénaut, Alain, Darbon, Jean-Marie

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Discovery of S64315, a Potent and Selective Mcl‑1 Inhibitor von Szlavik, Zoltan, Csekei, Marton, Paczal, Attila, Szabo, Zoltan B, Sipos, Szabolcs, Radics, Gabor, Proszenyak, Agnes, Balint, Balazs, Murray, James, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Daniels, Zoe Marie, Hubbard, Roderick E, Le Toumelin-Braizat, Gaëtane, Claperon, Audrey, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Bruno, Alain, Chanrion, Maia, Colland, Frédéric, Maragno, Ana-Leticia, Demarles, Didier, Geneste, Olivier, Kotschy, Andras

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Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity von Vasas, Attila, Ivanschitz, Lisa, Molnár, Balázs, Kiss, Árpád, Baker, Lisa, Fiumana, Andrea, Macias, Alba, Murray, James B., Sanders, Emma, Whitehead, Neil, Hubbard, Roderick E., Saunier, Carine, Monceau, Elodie, Girard, Anne Marie, Rousseau, Marion, Chanrion, Maia, Demarles, Didier, Geneste, Olivier, Weber, Csaba, Lewkowicz, Elodie, Kotschy, Andras

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S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth von Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J S, Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A, Morris, Erick, Murray, James, Geneste, Olivier

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Abstract 257: Targeting AML through apoptosis activation using Bcl-2/Mcl-1 or Bcl-2/Hdm2 inhibitor combination therapies von Wang, Youzhen, Qui, Shumei, Sanghavi, Sneha, Mulford, Iain, Lysiak, Gaëlle, Chanrion, Maïa, Mistry, Prakash, Pfaar, Ulrike, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fabre, Claire, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Halilovic, Ensar

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Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia von Moujalled, Donia M, Brown, Fiona C, Pomilio, Giovanna, Anstee, Natasha S, Litalien, Veronique, Thompson, Ella R, Morley, Thomas, MacRaild, Sarah, Chua, Chong C, Banquet, SéBastien, Chanrion, Maia, Maragno, Ana-Leticia, Schoumacher, Marie, Herold, Marco J, Lessene, Guillaume, Geneste, Olivier, Huang, David C.S., Roberts, Andrew W, Blombery, Piers, Wei, Andrew

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Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax von Tiran, Arnaud Le, Claperon, Audrey, Davidson, James, Starck, Jérôme-Benoit, Diguarher, Thierry Le, Chanrion, Maïa, Mistry, Prakash, Wang, Youzhen, Monceau, Elodie, Bernhardt, Fabienne, Rocchetti, Francesca, Lysiak-Auvity, Gaelle, Chen, Ijen, Daniels, Zoe, Pedder, Chris, Fallowfield, Mandy, Henlin, Jean-Michel, Fejes, Imre, Tatai, Janos, Nyerges, Miklos, Durand, Didier, Zarka, Marion, Sanghavi, Sneha, Girard, Anne-Marie, Schoumacher, Marie, Kraus-Berthier, Laurence, Newcombe, Rick, Halilovic, Ensar, Banquet, Sébastien, Rupin, Alain, Maacke, Heiko, Murray, James, Morris, Erick, Hofmann, Francesco, Colland, Frédéric, Geneste, Olivier

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Abstract 4482: S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models von Maragno, Ana Leticia, Mistry, Prakash, Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Toumelin-Braizat, Gaëtane Le, Chanrion, Maïa, Bruno, Alain, Claperon, Audrey, Maacke, Heiko, Morris, Erick, Wang, Youzhen, Derreal, Alix, Csekei, Márton, Paczal, Attila, Szabo, Zoltán, Sipos, Szabolcs, Proszenyak, Agnes, Balint, Balázs, Surgenor, Allan, Dokurno, Pawel, Matassova, Natalia, Chen, Ijen, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Grave, Fabienne, Colland, Frédéric, Halilovic, Ensar, Geneste, Olivier

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Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies von Halilovic, Ensar, Chanrion, Maïa, Mistry, Prakash, Wartmann, Markus, Qiu, Shumei, Sanghavi, Sneha, Chen, Yan, Lysiak, Gaëlle, Maragno, Ana Leticia, Pfaar, Ulrike, Huth, Felix, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Wang, Youzhen

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Abstract 5015: Innovative and predictive models against breast cancer von Duchamp, Olivier, Tabone-Eglinger, Severine, Mignard, Caroline, Goddard, Isabelle, Bruno, Alain, Chanrion, Maia, Calvet, Loreley, Degoul, Olivier, Dhondt, Kevin, Goetsch, Liliane, Miralves, Julie, Lautrette, Christophe, Pensec, Cindy, Vacon, Françoise Le, Treilleux, Isabelle, Arnould, Laurent, Vaglio, Philippe, Prevost, Grégoire, Tredan, Olivier

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