Screening and rank ordering of reversible mechanism-based inhibitors of Hepatitis C virus NS3 protease using electrospray ionization mass spectrometry von Liu, Yan-Hui, Ramanathan, Lata, Malcolm, Bruce, Njoroge, George, Chan, Tin-Yau, Pramanik, Birendra N.

Volltext

Discovery of hydroxy pyrimidine Factor IXa inhibitors von Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel

Volltext

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases von Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J

Volltext

Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase von Chen, Kevin X, Vibulbhan, Bancha, Yang, Weiying, Sannigrahi, Mousumi, Velazquez, Francisco, Chan, Tin-Yau, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Bennet, Frank, Jiang, Yueheng, Lesburg, Charles A, Duca, Jose, Pinto, Patrick, Gavalas, Stephen, Huang, Yuhua, Wu, Wanli, Selyutin, Oleg, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

Volltext

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles von Anilkumar, Gopinadhan N., Lesburg, Charles A., Selyutin, Oleg, Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Chan, Tin-Yau, Pu, Haiyan, Vaccaro, Henry, Wang, Li, Bennett, Frank, Chen, Kevin X., Duca, Jose, Gavalas, Stephen, Huang, Yuhua, Pinto, Patrick, Sannigrahi, Mousumi, Velazquez, Francisco, Venkatraman, Srikanth, Vibulbhan, Bancha, Agrawal, Sony, Butkiewicz, Nancy, Feld, Boris, Ferrari, Eric, He, Zhiqing, Jiang, Chuan-kui, Palermo, Robert E., Mcmonagle, Patricia, Huang, H.-C., Shih, Neng-Yang, Njoroge, George, Kozlowski, Joseph A.

Volltext

A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors von Chen, Kevin X, Lesburg, Charles A, Vibulbhan, Bancha, Yang, Weiying, Chan, Tin-Yau, Venkatraman, Srikanth, Velazquez, Francisco, Zeng, Qingbei, Bennett, Frank, Anilkumar, Gopinadhan N, Duca, Jose, Jiang, Yueheng, Pinto, Patrick, Wang, Li, Huang, Yuhua, Selyutin, Oleg, Gavalas, Stephen, Pu, Haiyan, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

Volltext

Discovery of an irreversible HCV NS5B polymerase inhibitor von Zeng, Qingbei, Nair, Anilkumar G., Rosenblum, Stuart B., Huang, Hsueh-Cheng, Lesburg, Charles A., Jiang, Yueheng, Selyutin, Oleg, Chan, Tin-Yau, Bennett, Frank, Chen, Kevin X., Venkatraman, Srikanth, Sannigrahi, Mousumi, Velazquez, Francisco, Duca, Jose S., Gavalas, Stephen, Huang, Yuhua, Pu, Haiyan, Wang, Li, Pinto, Patrick, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Li, Cheng, Hesk, David, Gesell, Jennifer, Sorota, Steve, Shih, Neng-Yang, Njoroge, F. George, Kozlowski, Joseph A.

Volltext

Pyrazolo[1,5- a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2 von Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J., Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Nomeir, Amin A., Wang, Yaolin, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Fran, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A., Paradkar, Vidyadhar M., Park, Haengsoon, Rokosz, Laura R., Stauffer, Tara M., Guzi, Timothy J.

Volltext

II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides von Anilkumar, Gopinadhan N., Selyutin, Oleg, Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Chan, Tin-Yau, Pu, Haiyan, Wang, Li, Bennett, Frank, Chen, Kevin X., Lesburg, Charles A., Duca, Jose, Gavalas, Stephen, Huang, Yuhua, Pinto, Patrick, Sannigrahi, Mousumi, Velazquez, Francisco, Venkatraman, Srikanth, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Huang, H.-C., Shih, Neng-Yang, George Njoroge, F., Kozlowski, Joseph A.

Volltext

Discovery of a Potent Thiadiazole Class of Histamine H 3 Receptor Antagonist for the Treatment of Diabetes von Rao, Ashwin U., Shao, Ning, Aslanian, Robert G., Chan, Tin-Yau, Degrado, Sylvia J., Wang, Li, McKittrick, Brian, Senior, Mary, West, Robert E., Williams, Shirley M., Wu, Ren-Long, Hwa, Joyce, Patel, Bhuneshwari, Zheng, Shuqin, Sondey, Christopher, Palani, Anandan

Volltext

The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors von Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

Volltext

Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate von Chen, Kevin X, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Lesburg, Charles A, Vibulbhan, Bancha, Velazquez, Francisco, Chan, Tin-Yau, Bennet, Frank, Jiang, Yueheng, Pinto, Patrick, Huang, Yuhua, Selyutin, Oleg, Agrawal, Sony, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

Volltext

Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists von Scott, Jack D., Miller, Michael W., Li, Sarah W., Lin, Sue-Ing, Vaccaro, Henry A., Hong, Liwu, Mullins, Deborra E., Guzzi, Mario, Weinstein, Jay, Hodgson, Robert A., Varty, Geoffrey B., Stamford, Andrew W., Chan, Tin-Yau, McKittrick, Brian A., Greenlee, William J., Priestley, Tony, Parker, Eric M.

Volltext

Carbohydrate-Based Small-Molecule Scaffolds for the Construction of Universal Pharmacophore Mapping Libraries von Sofia, Michael J, Hunter, Rachael, Chan, Tin Yau, Vaughan, Andrew, Dulina, Richard, Wang, Huiming, Gange, David

Volltext

Design of Compounds that Increase the Absorption of Polar Molecules von Bowe, C L, Mokhtarzadeh, L, Venkatesan, P, Babu, S, Axelrod, H R, Sofia, M J, Kakarla, R, Chan, T Y, Kim, J S, Lee, H J, Amidon, G L, Choe, S Y, Walker, S, Kahne, D

Volltext

The temporary silicon connection in the control of the regiochemistry of 4 + 2 cycloadditions von Stork, Gilbert, Chan, Tin Yau, Breault, Gloria A

Volltext

Identification of 2-aminooxazole amides as acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy von Kim, Hyunjin M., Smith, Michelle D., Kim, Jae-Hun, Caplen, Mary Ann, Chan, Tin Yau, McKittrick, Brian A., Cook, John A., van Heek, Margaret, Lachowicz, Jean

Volltext

Temporary Magnesium and Aluminum Connections in [4 + 2] Cycloadditions von Stork, Gilbert, Chan, Tin Yau

Volltext

Biomimetic synthesis of yeuhchukene von Cheng, Kin-Fai, Kong, Yun-Cheung, Chan, Tin-Yau

Volltext

Discovery of a Potent Thiadiazole Class of Histamine H3 Receptor Antagonist for the Treatment of Diabetes von Rao, Ashwin U, Shao, Ning, Aslanian, Robert G, Chan, Tin-Yau, Degrado, Sylvia J, Wang, Li, McKittrick, Brian, Senior, Mary, West, Robert E, Williams, Shirley M, Wu, Ren-Long, Hwa, Joyce, Patel, Bhuneshwari, Zheng, Shuqin, Sondey, Christopher, Palani, Anandan

Volltext