Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects von Corbet, Cyril, Bastien, Estelle, Draoui, Nihed, Doix, Bastien, Mignion, Lionel, Jordan, Bénédicte F., Marchand, Arnaud, Vanherck, Jean-Christophe, Chaltin, Patrick, Schakman, Olivier, Becker, Holger M., Riant, Olivier, Feron, Olivier

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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir von Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K, De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M, Beigelman, Leonid, Symons, Julian A, Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication von Debyser, Zeger, Christ, Frauke, Voet, Arnout, Marchand, Arnaud, Nicolet, Stefan, Desimmie, Belete A, Marchand, Damien, Bardiot, Dorothée, Van der Veken, Nam Joo, Van Remoortel, Barbara, Strelkov, Sergei V, De Maeyer, Marc, Chaltin, Patrick

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Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release von Held, Katharina, Kichko, Tatjana, De Clercq, Katrien, Klaassen, Hugo, Van Bree, Rieta, Vanherck, Jean-Christophe, Marchand, Arnaud, Reeh, Peter W., Chaltin, Patrick, Voets, Thomas, Vriens, Joris

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Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization von CHRIST, Frauke, SHAW, Stephen, PICKFORD, Chris, DEMEULEMEESTER, Jonas, DESIMMIE, Belete A, MARCHAND, Arnaud, BUTLER, Scott, SMETS, Wim, CHALTIN, Patrick, WESTBY, Mike, DEBYSER, Zeger

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A Robust Phenotypic High-Throughput Antiviral Assay for the Discovery of Rabies Virus Inhibitors von Wang, Xinyu, Chiu, Winston, Klaassen, Hugo, Marchand, Arnaud, Chaltin, Patrick, Neyts, Johan, Jochmans, Dirk

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Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication von Bardiot, Dorothée, Vangeel, Laura, Koukni, Mohamed, Arzel, Philippe, Zwaagstra, Marleen, Lyoo, Heyrhyoung, Wanningen, Patrick, Ahmad, Shamshad, Zhang, Linlin, Sun, Xinyuanyuan, Delpal, Adrien, Eydoux, Cecilia, Guillemot, Jean-Claude, Lescrinier, Eveline, Klaassen, Hugo, Leyssen, Pieter, Jochmans, Dirk, Castermans, Karolien, Hilgenfeld, Rolf, Robinson, Colin, Decroly, Etienne, Canard, Bruno, Snijder, Eric J, van Hemert, Martijn J, van Kuppeveld, Frank, Chaltin, Patrick, Neyts, Johan, De Jonghe, Steven, Marchand, Arnaud

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Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa von Gerits, Evelien, Blommaert, Eline, Lippell, Anna, O'Neill, Alex J, Weytjens, Bram, De Maeyer, Dries, Fierro, Ana Carolina, Marchal, Kathleen, Marchand, Arnaud, Chaltin, Patrick, Spincemaille, Pieter, De Brucker, Katrijn, Thevissen, Karin, Cammue, Bruno P A, Swings, Toon, Liebens, Veerle, Fauvart, Maarten, Verstraeten, Natalie, Michiels, Jan

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Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells von Draoui, Nihed, Schicke, Olivier, Fernandes, Antony, Drozak, Xavier, Nahra, Fady, Dumont, Amélie, Douxfils, Jonathan, Hermans, Emmanuel, Dogné, Jean-Michel, Corbau, Romu, Marchand, Arnaud, Chaltin, Patrick, Sonveaux, Pierre, Feron, Olivier, Riant, Olivier

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Ibetazol, a novel inhibitor of importin β1-mediated nuclear import von Vercruysse, Thomas, Vanstreels, Els, Jacquemyn, Maarten, Boland, Sandro, Kilonda, Amuri, Allasia, Sara, Vandecaetsbeek, Ilse, Klaassen, Hugo, Versele, Matthias, Chaltin, Patrick, Marchand, Arnaud, Daelemans, Dirk

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Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import von Demeulemeester, Jonas, Blokken, Jolien, De Houwer, Stéphanie, Dirix, Lieve, Klaassen, Hugo, Marchand, Arnaud, Chaltin, Patrick, Christ, Frauke, Debyser, Zeger

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Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical In... von Defraine, Valerie, Verstraete, Laure, Van Bambeke, Françoise, Anantharajah, Ahalieyah, Townsend, Eleanor M, Ramage, Gordon, Corbau, Romu, Marchand, Arnaud, Chaltin, Patrick, Fauvart, Maarten, Michiels, Jan

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1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage von Defraine, Valerie, Liebens, Veerle, Loos, Evelien, Swings, Toon, Weytjens, Bram, Fierro, Carolina, Marchal, Kathleen, Sharkey, Liam, O'Neill, Alex J, Corbau, Romu, Marchand, Arnaud, Chaltin, Patrick, Fauvart, Maarten, Michiels, Jan

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Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease von Dumbacher, Michael, Van Dooren, Tom, Princen, Katrien, De Witte, Koen, Farinelli, Mélissa, Lievens, Sam, Tavernier, Jan, Dehaen, Wim, Wera, Stefaan, Winderickx, Joris, Allasia, Sara, Kilonda, Amuri, Spieser, Stéphane, Marchand, Arnaud, Chaltin, Patrick, Hoogenraad, Casper C, Griffioen, Gerard

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The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut von Paulussen, Frederik, Kulkarni, Chetan P, Stolz, Frank, Lescrinier, Eveline, De Graeve, Stijn, Lambin, Suzan, Marchand, Arnaud, Chaltin, Patrick, In't Veld, Peter, Mebis, Joseph, Tavernier, Jan, Van Dijck, Patrick, Luyten, Walter, Thevelein, Johan M

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Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen von Hamed, Mohamed Belal, Burchacka, Ewa, Angus, Liselotte, Marchand, Arnaud, De Geyter, Jozefien, Loos, Maria S., Anne, Jozef, Klaassen, Hugo, Chaltin, Patrick, Karamanou, Spyridoula, Economou, Anastassios

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Identification of fungicidal 2,6-disubstituted quinolines with activity against Candida biofilms von Delattin, Nicolas, Bardiot, Dorothée, Marchand, Arnaud, Chaltin, Patrick, De Brucker, Katrijn, Cammue, Bruno P A, Thevissen, Karin

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Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors von Bardiot, Dorothée, Koukni, Mohamed, Smets, Wim, Carlens, Gunter, Kaptein, Suzanne, Dallmeier, Kai, Chaltin, Patrick, Neyts, Johan, Marchand, Arnaud

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Functional expression and pharmacological modulation of TRPM3 in human sensory neurons von Vangeel, Laura, Benoit, Melissa, Miron, Yannick, Miller, Paul E., De Clercq, Katrien, Chaltin, Patrick, Verfaillie, Catherine, Vriens, Joris, Voets, Thomas

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A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction von Kaptein, Suzanne J. F., Goethals, Olivia, Kiemel, Dominik, Marchand, Arnaud, Kesteleyn, Bart, Bonfanti, Jean-François, Bardiot, Dorothée, Stoops, Bart, Jonckers, Tim H. M., Dallmeier, Kai, Geluykens, Peggy, Thys, Kim, Crabbe, Marjolein, Chatel-Chaix, Laurent, Münster, Max, Querat, Gilles, Touret, Franck, de Lamballerie, Xavier, Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Van Loock, Marnix, Neyts, Johan

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