The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia von Zhao, Lan, Oliver, Eduardo, Maratou, Klio, Atanur, Santosh S., Dubois, Olivier D., Cotroneo, Emanuele, Chen, Chien-Nien, Wang, Lei, Arce, Cristina, Chabosseau, Pauline L., Ponsa-Cobas, Joan, Frid, Maria G., Moyon, Benjamin, Webster, Zoe, Aldashev, Almaz, Ferrer, Jorge, Rutter, Guy A., Stenmark, Kurt R., Aitman, Timothy J., Wilkins, Martin R.

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ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition von Sui, Lina, Du, Qian, Romer, Anthony, Su, Qi, Chabosseau, Pauline L, Xin, Yurong, Kim, Jinrang, Kleiner, Sandra, Rutter, Guy A, Egli, Dieter

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124-OR: Repetitive Ca2+ Waves Emanate from a Stable Leader Cell in Mouse Islets von CHABOSSEAU, PAULINE L., MARTINEZ-SANCHEZ, AIDA, LECLERC, ISABELLE, SALEM, VICTORIA, RUTTER, GUY A.

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1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells von CHABOSSEAU, PAULINE L., YONG, SU WERN FIONA, LOPEZ, LIVIA, LECLERC, ISABELLE, ALI, YUSUF, MARTINEZ-SANCHEZ, AIDA, RUTTER, GUY A.

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1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo von DELGADILLO SILVA, LUIS F., RUTTER, GUY A., CHABOSSEAU, PAULINE L., PROVENCHER-GIRARD, AUDREY, PRAT, ALEXANDRE, LOPEZ NORIEGA, LIVIA

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1750-P: Differential Impacts of Two Novel HNF1A Variants Associated with Familial Young-Onset Diabetes on Protein Function and Insulin Secretion In Vitro von CHERKAOUI, INES, DU, QIAN, DION, CAMILLE, LEITCH, HARRY, CHABOSSEAU, PAULINE L., EGLI, DIETRICH M., SACHEDINA, DILSHAD, WASTIN, JULES, MISRA, SHIVANI, RUTTER, GUY A.

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2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulate... von GEORGIADOU, ELENI, CHABOSSEAU, PAULINE L., TOMAS, ALEJANDRA, LECLERC, ISABELLE, RUTTER, GUY A.

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320-OR: Bariatric Surgery Improves Ca2+ Dynamics across Pancreatic Islets In Vivo von AKALESTOU, ELINA, SUBA, KINGA, NORIEGA, LIVIA LOPEZ, CHABOSSEAU, PAULINE L., LECLERC, ISABELLE, SALEM, VICTORIA, RUTTER, GUY A.

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Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance von Mitchell, Ryan K, Hu, Ming, Chabosseau, Pauline L, Cane, Matthew C, Meur, Gargi, Bellomo, Elisa A, Carzaniga, Raffaella, Collinson, Lucy M, Li, Wen-Hong, Hodson, David J, Rutter, Guy A

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The Ca 2+ -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6 von Parks, Steven Z, Gao, Tian, Jimenez Awuapura, Natalia, Ayathamattam, Joseph, Chabosseau, Pauline L, Kalvakolanu, Dhananjaya V, Valdivia, Héctor H, Rutter, Guy A, Leclerc, Isabelle

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161-LB: Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice von AKALESTOU, ELINA, LOPEZ NORIEGA, LIVIA, CHABOSSEAU, PAULINE L., LECLERC, ISABELLE, RUTTER, GUY A.

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The Ca2+‐binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6 von Parks, Steven Z., Gao, Tian, Jimenez Awuapura, Natalia, Ayathamattam, Joseph, Chabosseau, Pauline L., Kalvakolanu, Dhananjaya V., Valdivia, Héctor H., Rutter, Guy A., Leclerc, Isabelle, Nakatogawa, Hitoshi

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38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin... von GEORGIADOU, ELENI, MURALIDHARAN, CHARANYA, CHABOSSEAU, PAULINE L., TOMAS, ALEJANDRA, STYLIANIDES, THEODOROS, LEGIDO-QUIGLEY, CRISTINA, ALSABEEH, NOUR, CRUCIANI-GUGLIELMACCI, CÉLINE, MAGNAN, CHRISTOPHE, IBBERSON, MARK, LECLERC, ISABELLE, LINNEMANN, AMELIA K., ALI, YUSUF, RODRIGUEZ, TRISTAN, RUTTER, GUY A.

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2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs β-Cell Function von Cheung, Rebecca, Pizza, Grazia, Rolando, Delphine M, Chabosseau, Pauline L, Nguyen-Tu, Marie-Sophie, Leclerc, Isabelle, Rutter, Guy A, Martinez-Sanchez, Aida

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2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs ß-Cell Function von CHEUNG, REBECCA, PIZZA, GRAZIA, ROLANDO, DELPHINE M., CHABOSSEAU, PAULINE L., NGUYEN-TU, MARIE-SOPHIE, LECLERC, ISABELLE, RUTTER, GUY A., MARTINEZ-SANCHEZ, AIDA

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Real-Time In Vivo Imaging of Whole Islet Ca2+ Dynamics Reveals Glucose-Induced Changes in Beta-Cell Connectivity in Mouse and Human Islets von SALEM, VICTORIA, SUBA, KINGA, ALONSO, ALDARA MARTIN, CHABOSSEAU, PAULINE L., GEORGIADOU, ELENI, STYLIANIDES, THEODOROS, BRIANT, LINFORD, HODSON, DAVID, CARRAT, GAELLE, LECLERC, ISABELLE, GABORIAU, DAVID C., ROTHERY, STEPHEN M., RUTTER, GUY A.

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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis von Mousavy Gharavy, S. Neda, Owen, Bryn M., Millership, Steven J., Chabosseau, Pauline, Pizza, Grazia, Martinez-Sanchez, Aida, Tasoez, Emirhan, Georgiadou, Eleni, Hu, Ming, Fine, Nicholas H. F., Jacobson, David A., Dickerson, Matthew T., Idevall-Hagren, Olof, Montoya, Alex, Kramer, Holger, Mehta, Zenobia, Withers, Dominic J., Ninov, Nikolay, Gadue, Paul J., Cardenas-Diaz, Fabian L., Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Voz, Marianne, Rutter, Guy A.

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Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice von Carrat, Gaelle R., Hu, Ming, Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Gaulton, Kyle J., van de Bunt, Martijn, Siddiq, Afshan, Falchi, Mario, Thurner, Matthias, Canouil, Mickaël, Pattou, Francois, Leclerc, Isabelle, Pullen, Timothy J., Cane, Matthew C., Prabhala, Priyanka, Greenwald, William, Schulte, Anke, Marchetti, Piero, Ibberson, Mark, MacDonald, Patrick E., Manning Fox, Jocelyn E., Gloyn, Anna L., Froguel, Philippe, Solimena, Michele, McCarthy, Mark I., Rutter, Guy A.

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An essential role for the Zn 2+ transporter ZIP7 in B cell development von Anzilotti, Consuelo, Swan, David J, Boisson, Bertrand, Deobagkar-Lele, Mukta, Oliveira, Catarina, Chabosseau, Pauline, Engelhardt, Karin R, Xu, Xijin, Chen, Rui, Alvarez, Luis, Berlinguer-Palmini, Rolando, Bull, Katherine R, Cawthorne, Eleanor, Cribbs, Adam P, Crockford, Tanya L, Dang, Tarana Singh, Fearn, Amy, Fenech, Emma J, de Jong, Sarah J, Lagerholm, B Christoffer, Ma, Cindy S, Sims, David, van den Berg, Bert, Xu, Yaobo, Cant, Andrew J, Kleiner, Gary, Leahy, T Ronan, de la Morena, M Teresa, Puck, Jennifer M, Shapiro, Ralph S, van der Burg, Mirjam, Chapman, J Ross, Christianson, John C, Davies, Benjamin, McGrath, John A, Przyborski, Stefan, Santibanez Koref, Mauro, Tangye, Stuart G, Werner, Andreas, Rutter, Guy A, Padilla-Parra, Sergi, Casanova, Jean-Laurent, Cornall, Richard J, Conley, Mary Ellen, Hambleton, Sophie

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CO-38 - Réduction de l’expression de STARD10 associée à une altération de la sécrétion d’insuline chez l’homme et la souris von Carrat, Gaelle, Hu, Ming, NGuyen-Tu, Marie-Sophie, Chabosseau, Pauline, Gaulton, Kyle, van de Bunt, Martijn, Siddiq, Afshan, Falchi, Mario, Thurner, Matthias, Pullen, Timothy J., Cane, Matthew, Prabhala, Priyanka, Schulte, Anke, Marchetti, Piero, Patrick MacDonald, Mark Ibberson, Manning Fox, Jocelyn E., Gloyn, Anna L., Froguel, Philippe, Solimena, Michele, McCarthy, Mark I., Rutter, Guy A.

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