Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy par... von Timmers, Maarten, Ravenstijn, Paulien, Xi, Liwen, Triana-Baltzer, Gallen, Furey, Maura, Van Hemelryck, Sandy, Biewenga, Jeike, Ceusters, Marc, Bhattacharya, Anindya, van den Boer, Maarten, van Nueten, Luc, de Boer, Peter

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Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder von Recourt, Kasper, de Boer, Peter, van der Ark, Peter, Benes, Heike, van Gerven, Joop M. A., Ceusters, Marc, van Nueten, Luc, Drevets, Wayne C., Bhatacharya, Anindya, Browning, Michael, Jacobs, Gabriel E.

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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432 von Lord, Brian, Aluisio, Leah, Shoblock, James R, Neff, Robert A, Varlinskaya, Elena I, Ceusters, Marc, Lovenberg, Timothy W, Carruthers, Nicholas, Bonaventure, Pascal, Letavic, Michael A, Deak, Terrence, Drinkenburg, Wilhelmus, Bhattacharya, Anindya

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Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice von Ruiz-Ruiz, Cristina, García-Magro, Nuria, Negredo, Pilar, Avendaño, Carlos, Bhattacharya, Anindya, Ceusters, Marc, García, Antonio G.

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Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders von Bhattacharya, Anindya, Ceusters, Marc

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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice von Mamad, Omar, Heiland, Mona, Lindner, Andreas U, Hill, Thomas D M, Ronroy, Ronan M, Rentrup, Kilian, Sanz-Rodriguez, Amaya, Langa, Elena, Heller, Janosch P, Moreno, Oscar, Llop, Jordi, Bhattacharya, Anindya, Palmer, James A, Ceusters, Marc, Engel, Tobias, Henshall, David C

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Discovery of 8‑Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)­methyl]-1,2,4-triazolo[4,3‑a]pyridine (JNJ-46356479), a Selective and Orally Bioavailab... von Cid, Jose María, Tresadern, Gary, Vega, Juan Antonio, de Lucas, Ana Isabel, del Cerro, Alcira, Matesanz, Encarnación, Linares, María Lourdes, García, Aránzazu, Iturrino, Laura, Pérez-Benito, Laura, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Peeters, Luc, Ceusters, Marc, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Mackie, Claire, Somers, Marijke, Trabanco, Andrés A

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Profiling classical neuropsychiatric biomarkers across biological fluids and following continuous lumbar puncture: A guide to sample type and time von Triana-Baltzer, Gallen, Timmers, Maarten, De Boer, Peter, Schoene, Manja, Furey, Maura, Bleys, Cathy, Vrancken, Isabeau, Slemmon, Randy, Ceusters, Marc, van Nueten, Luc, Kolb, Hartmuth

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P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy von Amhaoul, Halima, Ali, Idrish, Mola, Marco, Van Eetveldt, Annemie, Szewczyk, Krystyna, Missault, Stephan, Bielen, Kenny, Kumar-Singh, Samir, Rech, Jason, Lord, Brian, Ceusters, Marc, Bhattacharya, Anindya, Dedeurwaerdere, Stefanie

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Are extreme returns priced in the stock market? European evidence von Annaert, Jan, De Ceuster, Marc, Verstegen, Kurt

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What determines Euro area bank CDS spreads? von Annaert, Jan, De Ceuster, Marc, Van Roy, Patrick, Vespro, Cristina

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Efficient Spread Betting Markets: A Literature Review von Vandenbruaene, Jonas, Ceuster, Marc De, Annaert, Jan

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4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidat... von Letavic, Michael A., Savall, Brad M., Allison, Brett D., Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A., Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I., Ceusters, Marc, Coe, Kevin J., Dvorak, Curt A., Fraser, Ian C., Gelin, Christine F., Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W., Otieno, Monicah A., Schoetens, Freddy, Swanson, Devin M., Wang, Qi, Wickenden, Alan D., Bhattacharya, Anindya

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The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice von Smith, Jonathon, Menéndez Méndez, Aida, Alves, Mariana, Parras, Alberto, Conte, Giorgia, Bhattacharya, Anindya, Ceusters, Marc, Nicke, Annette, Henshall, David C., Jimenez‐Mateos, Eva M., Engel, Tobias

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Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice von Morgan, James, Moreno, Oscar, Alves, Mariana, Baz, Zuriñe, Menéndez Méndez, Aida, Leister, Hanna, Melia, Ciara, Smith, Jonathon, Visekruna, Alexander, Nicke, Annette, Bhattacharya, Anindya, Ceusters, Marc, Henshall, David C., Gómez‐Vallejo, Vanessa, Llop, Jordi, Engel, Tobias

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Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice von Morgan, James, Moreno, Oscar, Alves, Mariana, Baz, Zuriñe, Menéndez Méndez, Aida, Leister, Hanna, Melia, Ciara, Smith, Jonathon, Visekruna, Alexander, Nicke, Annette, Bhattacharya, Anindya, Ceusters, Marc, Henshall, David C, Gómez-Vallejo, Vanessa, Llop, Jordi, Engel, Tobias

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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]­pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate... von Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya

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Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2–positive allosteric modulator JNJ‐46356479 and levetiracetam in the mouse 6‐Hz (4... von Metcalf, Cameron S., Klein, Brian D., Smith, Misty D., Ceusters, Marc, Lavreysen, Hilde, Pype, Stefan, Van Osselaer, Nancy, Twyman, Roy, White, H. Steve

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74. Mechanisms of Agoraphobia: Contribution of Orexin and mGluR2 Signaling in the Amygdala von Molosh, Andrei, Dustrude, Erik, Lukkes, Jodi, Truitt, William, Bhatnagar, Seema, Donck, Luc ver, Kent, Justine, Ceusters, Marc, Bonaventure, Pascal, Johnson, Philip, Shekhar, Anantha

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Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression von Kent, Justine M., Daly, Ella, Kezic, Iva, Lane, Rosanne, Lim, Pilar, De Smedt, Heidi, De Boer, Peter, Van Nueten, Luc, Drevets, Wayne C., Ceusters, Marc

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