Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs von Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E

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p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates von Van Nguyen, Thang, Li, Jing, Lu, Chin-Chun (Jean), Mamrosh, Jennifer L., Lu, Gang, Cathers, Brian E., Deshaies, Raymond J.

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Cereblon modulators: Low molecular weight inducers of protein degradation von Chamberlain, Philip P., Cathers, Brian E.

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Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity von Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh

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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos von Matyskiela, Mary E, Zhang, Weihong, Man, Hon-Wah, Muller, George, Khambatta, Godrej, Baculi, Frans, Hickman, Matthew, LeBrun, Laurie, Pagarigan, Barbra, Carmel, Gilles, Lu, Chin-Chun, Lu, Gang, Riley, Mariko, Satoh, Yoshitaka, Schafer, Peter, Daniel, Thomas O, Carmichael, James, Cathers, Brian E, Chamberlain, Philip P

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A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase von Matyskiela, Mary E, Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn'Al, Lander, Gabriel C, Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L, Handa, Hiroshi, Carmichael, James, Daniel, Thomas O, Cathers, Brian E, Lopez-Girona, Antonia, Chamberlain, Philip P

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS von Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D. R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound von Sun, Daekyu, Thompson, Brian, Cathers, Brian E, Salazar, Miguel, Kerwin, Sean M, Trent, John O, Jenkins, Terence C, Neidle, Stephen, Hurley, Laurence H

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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia von Hansen, Joshua D, Correa, Matthew, Alexander, Matt, Nagy, Mark, Huang, Dehua, Sapienza, John, Lu, Gang, LeBrun, Laurie A, Cathers, Brian E, Zhang, Weihong, Tang, Yang, Ammirante, Massimo, Narla, Rama K, Piccotti, Joseph R, Pourdehnad, Michael, Lopez-Girona, Antonia

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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase von Matyskiela, Mary E., Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn’Al, Lander, Gabriel C., Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L., Handa, Hiroshi, Carmichael, James, Daniel, Thomas O., Cathers, Brian E., Lopez-Girona, Antonia, Chamberlain, Philip P.

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Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice von Dufu, Kobina, Williams, Alexander T., Muller, Cynthia R., Walser, Cynthia M., Lucas, Alfredo, Eaker, Allyn M., Alt, Carsten, Cathers, Brian E., Oksenberg, Donna, Cabrales, Pedro

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GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model von Dufu, Kobina, Alt, Carsten, Strutt, Steven, Partridge, James, Tang, Tzechiang, Siu, Vincent, Liao‐Zou, Hilary, Rademacher, Peter, Williams, Alexander T., Muller, Cynthia R., Geng, Xin, Pochron, Mira Patel, Dang, Annie Nguyen, Cabrales, Pedro, Li, Zhe, Oksenberg, Donna, Cathers, Brian E.

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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma von Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia

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Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005 von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization von Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K

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Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase von Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R., Cathers, Brian E., Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor von Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223 von Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita

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Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury von Krenitsky, Véronique Plantevin, Delgado, Mercedes, Nadolny, Lisa, Sahasrabudhe, Kiran, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Kois, Adam, Hughes, Kevin, Wright, Jonathan, Nowakowski, Jacek, Sudbeck, Elise, Ghosh, Sutapa, Bahmanyar, Sogole, Chamberlain, Philip, Muir, Jeff, Cathers, Brian E., Giegel, David, Xu, Li, Celeridad, Maria, Moghaddam, Mehran, Khatsenko, Oleg, Omholt, Paul, Katz, Jason, Pai, Sema, Fan, Rachel, Tang, Yang, Shirley, Michael A., Benish, Brent, Blease, Kate, Raymon, Heather, Bhagwat, Shripad, Henderson, Ian, Cole, Andrew G., Bennett, Brydon, Satoh, Yoshitaka

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Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease von Dufu, Kobina, Oksenberg, Donna, Cathers, Brian E, Munoz, Carlos J, Muller, Cynthia R, Pedro Cabrales, Pedro

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