Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists von Toy, Weiyi, Weir, Hazel, Razavi, Pedram, Lawson, Mandy, Goeppert, Anne U, Mazzola, Anne Marie, Smith, Aaron, Wilson, Joanne, Morrow, Christopher, Wong, Wai Lin, De Stanchina, Elisa, Carlson, Kathryn E, Martin, Teresa S, Uddin, Sharmeen, Li, Zhiqiang, Fanning, Sean, Katzenellenbogen, John A, Greene, Geoffrey, Baselga, José, Chandarlapaty, Sarat

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation von Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

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Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells von Stender, Joshua D., Nwachukwu, Jerome C., Kastrati, Irida, Kim, Yohan, Strid, Tobias, Yakir, Maayan, Srinivasan, Sathish, Nowak, Jason, Izard, Tina, Rangarajan, Erumbi S., Carlson, Kathryn E., Katzenellenbogen, John A., Yao, Xin-Qiu, Grant, Barry J., Leong, Hon S., Lin, Chin-Yo, Frasor, Jonna, Nettles, Kendall W., Glass, Christopher K.

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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells von Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L

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Predictive features of ligand‐specific signaling through the estrogen receptor von Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W

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Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity von Min, Jian, Wang, Pengcheng, Srinivasan, Sathish, Nwachukwu, Jerome C, Guo, Pu, Huang, Minjian, Carlson, Kathryn E, Katzenellenbogen, John A, Nettles, Kendall W, Zhou, Hai-Bing

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Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands von Sharma, Naina, Carlson, Kathryn E, Nwachukwu, Jerome C, Srinivasan, Sathish, Sharma, Abhishek, Nettles, Kendall W, Katzenellenbogen, John A

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Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor von Liao, Zong-Quan, Dong, Chune, Carlson, Kathryn E, Srinivasan, Sathish, Nwachukwu, Jerome C, Chesnut, Robert W, Sharma, Abhishek, Nettles, Kendall W, Katzenellenbogen, John A, Zhou, Hai-Bing

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Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor von LaFrate, Andrew L., Gunther, Jillian R., Carlson, Kathryn E., Katzenellenbogen, John A.

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Characterization of the Pharmacophore Properties of Novel Selective Estrogen Receptor Downregulators (SERDs) von Kieser, Karen J, Kim, Dong Wook, Carlson, Kathryn E, Katzenellenbogen, Benita S, Katzenellenbogen, John A

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Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes von Bertini, Simone, De Cupertinis, Andrea, Granchi, Carlotta, Bargagli, Barbara, Tuccinardi, Tiziano, Martinelli, Adriano, Macchia, Marco, Gunther, Jillian R., Carlson, Kathryn E., Katzenellenbogen, John A., Minutolo, Filippo

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Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation von Irani, Seema, Tan, Wuwei, Li, Qing, Toy, Weiyi, Jones, Catherine, Gadiya, Mayur, Marra, Antonio, Katzenellenbogen, John A, Carlson, Kathryn E, Katzenellenbogen, Benita S, Karimi, Mostafa, Segu Rajappachetty, Ramya, Del Priore, Isabella S, Reis-Filho, Jorge S, Shen, Yang, Chandarlapaty, Sarat

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Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enable the Selective Synthesis of Benzestrol Isomers von Angle, Samantha R., Sharma, Hayden A., Choi, Christie K., Carlson, Kathryn E., Hou, Yingwei, Nwachukwu, Jerome C., Kim, Sung Hoon, Katzenellenbogen, Benita S., Nettles, Kendall W., Katzenellenbogen, John A., Jacobsen, Eric N.

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Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues von Madak-Erdogan, Zeynep, Kim, Sung Hoon, Gong, Ping, Zhao, Yiru C, Zhang, Hui, Chambliss, Ken L, Carlson, Kathryn E, Mayne, Christopher G, Shaul, Philip W, Korach, Kenneth S, Katzenellenbogen, John A, Katzenellenbogen, Benita S

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Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor von Muthyala, Rajeev S, Sheng, Shubin, Carlson, Kathryn E, Katzenellenbogen, Benita S, Katzenellenbogen, John. A

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Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community von Chen, Karen Lee Ann, Liu, Xiaoji, Zhao, Yiru Chen, Hieronymi, Kadriye, Rossi, Gianluigi, Auvil, Loretta Sue, Welge, Michael, Bushell, Colleen, Smith, Rebecca Lee, Carlson, Kathryn E., Kim, Sung Hoon, Katzenellenbogen, John A., Miller, Michael Joseph, Madak-Erdogan, Zeynep

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New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons von Wang, Lucia, Guillen, Valeria S, Sharma, Naina, Flessa, Kevin, Min, Jian, Carlson, Kathryn E, Toy, Weiyi, Braqi, Sara, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Chandarlapaty, Sarat, Sharma, Abhishek

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Fluorine-Substituted Cyclofenil Derivatives as Estrogen Receptor Ligands:  Synthesis and Structure−Affinity Relationship Study of Potential Positron Emission Tomography Agents for... von Seo, Jai Woong, Comninos, John S., Chi, Dae Yoon, Kim, Dong Wook, Carlson, Kathryn E., Katzenellenbogen, John A.

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Dual-mechanism estrogen receptor inhibitors von Min, Jian, Nwachukwu, Jerome C., Min, Charles K., Njeri, Jacqline W., Srinivasan, Sathish, Rangarajan, Erumbi S., Nettles, Charles C., Guillen, Valeria Sanabria, Ziegler, Yvonne, Yan, Shunchao, Carlson, Kathryn E., Hou, Yingwei, Kim, Sung Hoon, Novick, Scott, Pascal, Bruce D., Houtman, Rene, Griffin, Patrick R., Izard, Tina, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Nettles, Kendall W.

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Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer von Mayne, Christopher G., Toy, Weiyi, Carlson, Kathryn E., Bhatt, Trusha, Fanning, Sean W., Greene, Geoffrey L., Katzenellenbogen, Benita S., Chandarlapaty, Sarat, Katzenellenbogen, John A., Tajkhorshid, Emad

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