Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor von Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei

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The deubiquitylase USP9X controls ribosomal stalling von Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J, Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P, O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A, Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M, Urbé, Sylvie, Clague, Michael J

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Therapeutic Proteins von Dimitrov, Dimiter S.

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Molecular basis of USP7 inhibition by selective small-molecule inhibitors von Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors von Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan

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Correction: The deubiquitylase USP9X controls ribosomal stalling von Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J, Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P, O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A, Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M, Urbé, Sylvie, Clague, Michael J

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Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists von Smalley, Jr, Terrence L, Boggs, Sharon, Caravella, Justin A, Chen, Lihong, Creech, Katrina L, Deaton, David N, Kaldor, Istvan, Parks, Derek J

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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway von Baker, Keith D., Shewchuk, Lisa M., Kozlova, Tatiana, Makishima, Makoto, Hassell, Annie, Wisely, Bruce, Caravella, Justin A., Lambert, Millard H., Reinking, Jeffrey L., Krause, Henry, Thummel, Carl S., Willson, Timothy M., Mangelsdorf, David J.

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Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene von Bass, Jonathan Y., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Mills, Wendy Y., Navas, Frank, Parks, Derek J., Smalley, Terrence L., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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FXR agonist activity of conformationally constrained analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.

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Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064 von Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene von Akwabi-Ameyaw, Adwoa, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Computational Methods to Predict Therapeutic Protein Aggregation von Buck, Patrick M., Kumar, Sandeep, Wang, Xiaoling, Agrawal, Neeraj J., Trout, Bernhardt L., Singh, Satish K.

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Highly covarying residues have a functional role in antibody constant domains von Proctor, Elizabeth A., Kota, Pradeep, Demarest, Stephen J., Caravella, Justin A., Dokholyan, Nikolay V.

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Engineering of Affibody Molecules for Therapy and Diagnostics von Feldwisch, Joachim, Tolmachev, Vladimir

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Design of next-generation protein therapeutics von Caravella, Justin, Lugovskoy, Alexey

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The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily von Maglich, Jodi M., Caravella, Justin A., Lambert, Millard H., Willson, Timothy M., Moore, John T., Ramamurthy, Lakshman

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Therapeutic Proteins: Methods and Protocols von Voynov, Vladimir, Caravella, Justin A

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Metric to Distinguish Closely Related Domain Families Using Sequence Information von Proctor, Elizabeth A., Kota, Pradeep, Demarest, Stephen J., Caravella, Justin A., Dokholyan, Nikolay V.

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