Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies von Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Capotosti, Francesca, Mueller, Andre, Berndt, Mathias, Schmitt-Willich, Heribert, Darmency, Vincent, Gabellieri, Emanuele, Boudou, Cédric, Juergens, Tanja, Varisco, Yvan, Vokali, Efthymia, Hickman, David T., Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew

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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases von Smith, Ruben, Capotosti, Francesca, Schain, Martin, Ohlsson, Tomas, Vokali, Efthymia, Molette, Jerome, Touilloux, Tanja, Hliva, Valerie, Dimitrakopoulos, Ioannis K., Puschmann, Andreas, Jögi, Jonas, Svenningsson, Per, Andréasson, Mattias, Sandiego, Christine, Russell, David S., Miranda-Azpiazu, Patricia, Halldin, Christer, Stomrud, Erik, Hall, Sara, Bratteby, Klas, Tampio L’Estrade, Elina, Luthi-Carter, Ruth, Pfeifer, Andrea, Kosco-Vilbois, Marie, Streffer, Johannes, Hansson, Oskar

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Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways von Capotosti, Francesca, Hsieh, James J.-D., Herr, Winship

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PRECLINICAL CHARACTERIZATION OF PI-2620, A NOVEL TAU PET TRACER FOR DETECTION OF TAU IN AD AND OTHER TAUOPATHIES von Mueller, Andre, Kroth, Heiko, Schieferstein, Hanno, Berndt, Mathias, Oden, Felix, Capotosti, Francesca, Molette, Jerome, Juergens, Tanja, Darmency, Vincent, Schmitt-Willich, Heribert, Hickman, David, Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew

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Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance von Dubrot, Juan, Duraes, Fernanda V, Potin, Lambert, Capotosti, Francesca, Brighouse, Dale, Suter, Tobias, LeibundGut-Landmann, Salomé, Garbi, Natalio, Reith, Walter, Swartz, Melody A, Hugues, Stéphanie

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O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1 von Capotosti, Francesca, Guernier, Sophie, Lammers, Fabienne, Waridel, Patrice, Cai, Yong, Jin, Jingji, Conaway, Joan W., Conaway, Ronald C., Herr, Winship

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Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells von Hirosue, Sachiko, Vokali, Efthymia, Raghavan, Vidya R, Rincon-Restrepo, Marcela, Lund, Amanda W, Corthésy-Henrioud, Patricia, Capotosti, Francesca, Halin Winter, Cornelia, Hugues, Stéphanie, Swartz, Melody A

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Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core von Kroth, Heiko, Oden, Felix, Serra, Andreia Monica, Molette, Jerome, Mueller, Andre, Berndt, Mathias, Capotosti, Francesca, Gabellieri, Emanuele, Schmitt-Willich, Heribert, Hickman, David, Pfeifer, Andrea, Dinkelborg, Ludger, Stephens, Andrew

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PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer’s Disease and Other T... von Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Gabellieri, Emanuele, Mueller, Andre, Berndt, Mathias, Sreenivasachary, Nampally, Serra, Andreia Monica, Capotosti, Francesca, Schmitt-Willich, Heribert, Hickman, David, Pfeifer, Andrea, Dinkelborg, Ludger, Stephens, Andrew

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Update on [18F]ACI‐12589: a novel and promising PET tracer for a‐synuclein von Capotosti, Francesca, Smith, Ruben, Vokali, Efthymia, Molette, Jerome, Ohlsson, Tomas, Schain, Martin, Ravache, Myriam, Dimitrakopoulos, Ioannis K, Delgado, Christophe, Kocher, Jacqueline, Pittet, Laure, Vallet, Coralie, Luthi‐Carter, Ruth, Hliva, Valerie, Pfeifer, Andrea, Kosco‐Vilbois, Marie, Streffer, Johannes, Hansson, Oskar

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Optimizing the reaction conditions for the GMP production of [18F]ACI-12589, a promising candidate in the development as a PET tracer targeting α-synuclein von Bratteby, Klas, L’Estrade, Elina Tampio, Dimitrakopoulos, Ioannis, Molette, Jerome, Gabos, Bálint, Henriksson, Annéa, Capotosti, Francesca, Hansson, Oskar, Smith, Ruben, Ohlsson, Tomas

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P-070 - Optimizing the reaction conditions for the GMP production of [18F]ACI-12589, a promising candidate in the development as a PET tracer targeting α-synuclein von Bratteby, Klas, L’Estrade, Elina Tampio, Dimitrakopoulos, Ioannis, Molette, Jerome, Gabos, Bálint, Henriksson, Annéa, Capotosti, Francesca, Hansson, Oskar, Smith, Ruben, Ohlsson, Tomas

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Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzhe... von Gabellieri, Emanuele, Capotosti, Francesca, Molette, Jerome, Sreenivasachary, Nampally, Mueller, Andre, Berndt, Mathias, Schieferstein, Hanno, Juergens, Tanja, Varisco, Yvan, Oden, Felix, Schmitt-Willich, Heribert, Hickman, David, Dinkelborg, Ludger, Stephens, Andrew, Pfeifer, Andrea, Kroth, Heiko

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Initial clinical scans using [18F]ACI‐12589, a novel α‐synuclein PET‐tracer von Smith, Ruben, Capotosti, Francesca, Schain, Martin, Ohlsson, Tomas, Touilloux, Tanja, Hliva, Valerie, Vokali, Efthymia, Luthi‐Carter, Ruth, Molette, Jerome, Dimitrakopoulos, Ioannis K, Jögi, Jonas, Stomrud, Erik, Hall, Sara, Bratteby, Klas, Tampio, Elina, Pfeifer, Andrea, Kosco‐Vilbois, Marie, Streffer, Johannes, Hansson, Oskar

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The development of [18F]ACI‐12589, a high affinity and selective alpha‐synuclein radiotracer, as a biomarker for Parkinson’s disease and other synucleinopathies von Capotosti, Francesca, Vokali, Efthymia, Molette, Jerome, Ravache, Myriam, Delgado, Christophe, Kocher, Jacqueline, Pittet, Laure, Dimitrakopoulos, Ioannis K., Di‐Bonaventura, Ivan, Touilloux, Tanja, Piorkowska, Kasia, Chauhan, Mayank, Kroth, Heiko, Hliva, Valerie, Sol, Olivier, Pfeifer, Andrea, Kosco‐Vilbois, Marie

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Discovery of [18F]ACI‐12589, a Novel and Promising PET‐Tracer for Alpha‐Synuclein von Capotosti, Francesca, Vokali, Efthymia, Molette, Jerome, Ravache, Myriam, Delgado, Christophe, Kocher, Jacqueline, Pittet, Laure, Vallet, Coralie, Serra, Andreia, Piorkowska, Kasia, Dimitrakopoulos, Ioannis K, Luthi‐Carter, Ruth, Tsika, Elpida, Touilloux, Tanja, Hliva, Valerie, Smith, Ruben, Hansson, Oskar, Streffer, Johannes, Pfeifer, Andrea, Kosco‐Vilbois, Marie

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Developing a novel alpha‐synuclein positron emission tomography (PET) tracer for the diagnosis of synucleinopathies von Capotosti, Francesca, Vokali, Efthymia, Molette, Jerome, Tsika, Elpida, Ravache, Myriam, Juergens, Tanja, Melo dos Santos, Antonio, Darmency, Vincent, Piorkowska, Kasia, Chauhan, Mayank, Kroth, Heiko, Hliva, Valerie, Sol, Olivier, Pfeifer, Andrea, Kosco‐Vilbois, Marie

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Developing a novel alpha‐synuclein positron emission tomography (PET) tracer for the diagnosis of synucleinopathies: Neuroimaging: Other neurodegenerative disorders von Capotosti, Francesca, Vokali, Efthymia, Molette, Jerome, Tsika, Elpida, Ravache, Myriam, Juergens, Tanja, Melo dos Santos, Antonio, Darmency, Vincent, Piorkowska, Kasia, Chauhan, Mayank, Kroth, Heiko, Hliva, Valerie, Sol, Olivier, Pfeifer, Andrea, Kosco‐Vilbois, Marie

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SMALL MOLECULES TARGETING TAU AGGREGATION DECREASE TAU PATHOLOGY AND NEUROINFLAMMATION IN VIVO von Capotosti, Francesca, Nampally, Sreenivasachary, Lamontanara, Allan, Rodriguez, Patrick, Varisco, Yvan, Gabellieri, Emanuele, Piorkowska, Kasia, Kroth, Heiko, Hickman, David, Lowe, David, Pfeifer, Andrea, Poli, Sonia M.

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O5‐06‐03: SMALL MOLECULES TARGETING TAU AGGREGATION DECREASE TAU PATHOLOGY AND NEUROINFLAMMATION IN VIVO von Capotosti, Francesca, Nampally, Sreenivasachary, Lamontanara, Allan, Rodriguez, Patrick, Varisco, Yvan, Gabellieri, Emanuele, Piorkowska, Kasia, Kroth, Heiko, Hickman, David, Lowe, David, Pfeifer, Andrea, Poli, Sonia M.

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