Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF -Mutant Melanoma von Delord, Jean-Pierre, Robert, Caroline, Nyakas, Marta, McArthur, Grant A, Kudchakar, Ragini, Mahipal, Amit, Yamada, Yasuhide, Sullivan, Ryan, Arance, Ana, Kefford, Richard F, Carlino, Matteo S, Hidalgo, Manuel, Gomez-Roca, Carlos, Michel, Daniela, Seroutou, Abdelkader, Aslanis, Vassilios, Caponigro, Giordano, Stuart, Darrin D, Moutouh-de Parseval, Laure, Demuth, Tim, Dummer, Reinhard

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Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma von Wood, Andrew C, Krytska, Kateryna, Ryles, Hannah T, Infarinato, Nicole R, Sano, Renata, Hansel, Theodore D, Hart, Lori S, King, Frederick J, Smith, Timothy R, Ainscow, Edward, Grandinetti, Kathryn B, Tuntland, Tove, Kim, Sunkyu, Caponigro, Giordano, He, You Qun, Krupa, Shiva, Li, Nanxin, Harris, Jennifer L, Mossé, Yaël P

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Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma von Hart, Lori S, Rader, JulieAnn, Raman, Pichai, Batra, Vandana, Russell, Mike R, Tsang, Matthew, Gagliardi, Maria, Chen, Lucy, Martinez, Daniel, Li, Yimei, Wood, Andrew, Kim, Sunkyu, Parasuraman, Sudha, Delach, Scott, Cole, Kristina A, Krupa, Shiva, Boehm, Markus, Peters, Malte, Caponigro, Giordano, Maris, John M

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Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma von RADER, Julieann, RUSSELL, Mike R, SUNKYU KIM, PARASURAMAN, Sudha, CAPONIGRO, Giordano, SCHNEPP, Robert W, WOOD, Andrew C, PAWEL, Bruce, COLE, Kristina A, MARIS, John M, HART, Lori S, NAKAZAWA, Michael S, BELCASTRO, Lili T, MARTINEZ, Daniel, YIMEI LI, CARPENTER, Erica L, ATTIYEH, Edward F, DISKIN, Sharon J

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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF von Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

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Single-vector inducible lentiviral RNAi system for oncology target validation von Wiederschain, Dmitri, Susan, Wee, Chen, Lin, Loo, Alice, Yang, Guizhi, Huang, Alan, Chen, Yan, Caponigro, Giordano, Yao, Yung-mae, Lengauer, Christoph, Sellers, William R., Benson, John D.

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia von Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

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BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity von Emery, Caroline M, Monaco, Kelli-Ann, Wang, Ping, Balak, Marissa, Freeman, Alyson, Meltzer, Jodi, Delach, Scott M, Rakiec, Daniel, Ruddy, David A, Korn, Joshua M, Haling, Jacob, Acker, Michael G, Caponigro, Giordano

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition von Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Dalton, Krista M., Coon, Colin, Greninger, Patricia, Egan, Regina K., Stein, Giovanna T., Murchie, Ellen, McClanaghan, Joseph, Adachi, Yuta, Hirade, Kentaro, Dozmorov, Mikhail, Glod, John, Boikos, Sosipatros A., Ebi, Hiromichi, Hao, Huaixiang, Caponigro, Giordano, Benes, Cyril H., Faber, Anthony C.

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Abstract PS19-10: Preclinical head-to-head comparison of CDK4/6 inhibitor activity toward CDK4 vs CDK6 von Delach, Scott, Caponigro, Giordano

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Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death von Elis, Winfried, Triantafellow, Ellen, Wolters, Natalie M, Sian, Katie R, Caponigro, Giordano, Borawski, Jason, Gaither, L Alex, Murphy, Leon O, Finan, Peter M, Mackeigan, Jeffrey P

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Advances in the preclinical testing of cancer therapeutic hypotheses von Caponigro, Giordano, Sellers, William R.

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Next-generation characterization of the Cancer Cell Line Encyclopedia von Ghandi, Mahmoud, Huang, Franklin W., Jané-Valbuena, Judit, Kryukov, Gregory V., Lo, Christopher C., McDonald, E. Robert, Barretina, Jordi, Gelfand, Ellen T., Bielski, Craig M., Li, Haoxin, Hu, Kevin, Andreev-Drakhlin, Alexander Y., Kim, Jaegil, Hess, Julian M., Haas, Brian J., Aguet, François, Weir, Barbara A., Rothberg, Michael V., Paolella, Brenton R., Lawrence, Michael S., Akbani, Rehan, Lu, Yiling, Tiv, Hong L., Gokhale, Prafulla C., de Weck, Antoine, Mansour, Ali Amin, Oh, Coyin, Shih, Juliann, Hadi, Kevin, Rosen, Yanay, Bistline, Jonathan, Venkatesan, Kavitha, Reddy, Anupama, Sonkin, Dmitriy, Liu, Manway, Lehar, Joseph, Korn, Joshua M., Porter, Dale A., Jones, Michael D., Golji, Javad, Caponigro, Giordano, Taylor, Jordan E., Dunning, Caitlin M., Creech, Amanda L., Warren, Allison C., McFarland, James M., Zamanighomi, Mahdi, Kauffmann, Audrey, Stransky, Nicolas, Imielinski, Marcin, Maruvka, Yosef E., Cherniack, Andrew D., Tsherniak, Aviad, Vazquez, Francisca, Jaffe, Jacob D., Lane, Andrew A., Weinstock, David M., Johannessen, Cory M., Morrissey, Michael P., Stegmeier, Frank, Schlegel, Robert, Hahn, William C., Getz, Gad, Mills, Gordon B., Boehm, Jesse S., Golub, Todd R., Garraway, Levi A., Sellers, William R.

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Pharmacogenomic agreement between two cancer cell line data sets von Stransky, Nicolas, Ghandi, Mahmoud, Kryukov, Gregory V, Garraway, Levi A, Lehár, Joseph, Liu, Manway, Sonkin, Dmitriy, Kauffmann, Audrey, Venkatesan, Kavitha, Edelman, Elena J, Riester, Markus, Barretina, Jordi, Caponigro, Giordano, Schlegel, Robert, Sellers, William R, Stegmeier, Frank, Morrissey, Michael, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Haber, Daniel A, Ramaswamy, Sridhar, Benes, Cyril H, Menden, Michael P, Iorio, Francesco, Stratton, Michael R, McDermott, Ultan, Garnett, Mathew J, Saez-Rodriguez, Julio

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An essential component of the decapping enzyme required for normal rates of mRNA turnover von Beelman, Clare A., Stevens, Audrey, Caponigro, Giordano, LaGrandeur, Thomas E., Hatfield, Lianna, Fortner, David M., Parker, Roy

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Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling von Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D, Wong, Karrie, Gao, Hui, Meyer, Matthew J, Moody, Susan E, LaMarche, Matthew J, Engelman, Jeffrey A, Williams, Juliet A, Hammerman, Peter S, Abrams, Tinya J, Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity von Barretina, Jordi, Caponigro, Giordano, Stransky, Nicolas, Venkatesan, Kavitha, Margolin, Adam A., Kim, Sungjoon, Wilson, Christopher J., Lehár, Joseph, Kryukov, Gregory V., Sonkin, Dmitriy, Reddy, Anupama, Liu, Manway, Murray, Lauren, Berger, Michael F., Monahan, John E., Morais, Paula, Meltzer, Jodi, Korejwa, Adam, Jané-Valbuena, Judit, Mapa, Felipa A., Thibault, Joseph, Bric-Furlong, Eva, Raman, Pichai, Shipway, Aaron, Engels, Ingo H., Cheng, Jill, Yu, Guoying K., Yu, Jianjun, Aspesi, Peter, de Silva, Melanie, Jagtap, Kalpana, Jones, Michael D., Wang, Li, Hatton, Charles, Palescandolo, Emanuele, Gupta, Supriya, Mahan, Scott, Sougnez, Carrie, Onofrio, Robert C., Liefeld, Ted, MacConaill, Laura, Winckler, Wendy, Reich, Michael, Li, Nanxin, Mesirov, Jill P., Gabriel, Stacey B., Getz, Gad, Ardlie, Kristin, Chan, Vivien, Myer, Vic E., Weber, Barbara L., Porter, Jeff, Warmuth, Markus, Finan, Peter, Harris, Jennifer L., Meyerson, Matthew, Golub, Todd R., Morrissey, Michael P., Sellers, William R., Schlegel, Robert, Garraway, Levi A.

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SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors von Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas Manuel, Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M, Moody, Susan E, Engelman, Jeffrey A, Hammerman, Peter S, Caponigro, Giordano, Mohseni, Morvarid, Hao, Huai-Xiang

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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties von Gao, Yijun, Chang, Matthew T, McKay, Daniel, Na, Na, Zhou, Bing, Yaeger, Rona, Torres, Neilawattie M, Muniz, Keven, Drosten, Matthias, Barbacid, Mariano, Caponigro, Giordano, Stuart, Darrin, Moebitz, Henrik, Solit, David B, Abdel-Wahab, Omar, Taylor, Barry S, Yao, Zhan, Rosen, Neal

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LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors von Monaco, Kelli-Ann, Delach, Scott, Yuan, Jing, Mishina, Yuji, Fordjour, Paul, Labrot, Emma, McKay, Daniel, Guo, Ribo, Higgins, Stacy, Wang, Hui Qin, Liang, Jinsheng, Bui, Karen, Green, John, Aspesi, Peter, Ambrose, Jessi, Mapa, Felipa, Griner, Lesley, Jaskelioff, Mariela, Fuller, John, Crawford, Kenneth, Pardee, Gwynn, Widger, Stephania, Hammerman, Peter S, Engelman, Jeffrey A, Stuart, Darrin D, Cooke, Vesselina G, Caponigro, Giordano

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