Notch signalling in solid tumours: a little bit of everything but not all the time von Ranganathan, Prathibha, Weaver, Kelly L., Capobianco, Anthony J.

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Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis von Li, Bin, Flaveny, Colin A, Giambelli, Camilla, Fei, Dennis Liang, Han, Lu, Hang, Brian I, Bai, Feng, Pei, Xin-Hai, Nose, Vania, Burlingame, Oname, Capobianco, Anthony J, Orton, Darren, Lee, Ethan, Robbins, David J

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Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma von Lohse, Ines, Al-Ali, Hassan, Volmar, Claude-Henry, D Alvarez Trotta, Annamil, Brothers, Shaun P, Capobianco, Anthony J, Wahlestedt, Claes

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Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells von Alvarez-Trotta, Annamil, Guerrant, William, Astudillo, Luisana, Lahiry, Mohini, Diluvio, Giulia, Shersher, Elena, Kaneku, Hugo, Robbins, David J, Orton, Darren, Capobianco, Anthony J

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Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53 von LICCIULLI, Silvia, AVILA, Jacqueline L, CAPOBIANCO, Anthony J, KISSIL, Joseph L, HANLON, Linda, TROUTMAN, Scott, CESARONI, Matteo, KOTA, Smitha, KEITH, Brian, SIMON, M. Celeste, PURE, Ellen, RADTKE, Fred

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Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1 von Bhat, Ajaz A., Lu, Heng, Soutto, Mohammed, Capobianco, Anthony, Rai, Priyamvada, Zaika, Alexander, El-Rifai, Wael

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The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling von Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Adams, Amber A., Silver-Isenstadt, Maya, Sawyer, Leah M., Benchabane, Hassina, Wang, Huilan, Bunnag, Nawat, Li, Bin, Wynn, Daniel T., Yang, Fan, Garcia-Contreras, Marta, Williams, Charles H., Dakshanamurthy, Sivanesan, Hong, Charles C., Ayad, Nagi G., Capobianco, Anthony J., Ahmed, Yashi, Lee, Ethan, Robbins, David J.

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The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis von Astudillo, Luisana, Da Silva, Thiago G, Wang, Zhiqiang, Han, Xiaoqing, Jin, Ke, VanWye, Jeffrey, Zhu, Xiaoxia, Weaver, Kelly, Oashi, Taiji, Lopes, Pedro E M, Orton, Darren, Neitzel, Leif R, Lee, Ethan, Landgraf, Ralf, Robbins, David J, MacKerell, Jr, Alexander D, Capobianco, Anthony J

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Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened von BIN LI, LIANG FEI, Dennis, ORTON, Darren, LU HAN, BAOLIN WANG, CAPOBIANCO, Anthony J, ETHAN LEE, ROBBINS, David J, FLAVENY, Colin A, DAHMANE, Nadia, BAUBET, Valérie, ZHIQIANG WANG, FENG BAI, PEI, Xin-Hai, RODRIGUEZ-BIANCO, Jezabel, BRIAN HANG

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Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma von Wang, Zhiqiang, Da Silva, Thiago G, Jin, Ke, Han, Xiaoqing, Ranganathan, Prathibha, Zhu, Xiaoxia, Sanchez-Mejias, Avencia, Bai, Feng, Li, Bin, Fei, Dennis Liang, Weaver, Kelly, Carpio, Rodrigo Vasquez-Del, Moscowitz, Anna E, Koshenkov, Vadim P, Sanchez, Lilly, Sparling, Lynne, Pei, Xin-Hai, Franceschi, Dido, Ribeiro, Afonso, Robbins, David J, Livingstone, Alan S, Capobianco, Anthony J

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NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis von Shersher, Elena, Lahiry, Mohini, Alvarez-Trotta, Annamil, Diluvio, Giulia, Robbins, David J, Shiekhattar, Ramin, Capobianco, Anthony J

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Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study von Winterbottom, Emily F, Ban, Yuguang, Sun, Xiaodian, Capobianco, Anthony J, Marsit, Carmen J, Chen, Xi, Wang, Lily, Karagas, Margaret R, Robbins, David J

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc von Sharma, Vishva Mitra, Calvo, Jennifer A., Draheim, Kyle M., Cunningham, Leslie A., Hermance, Nicole, Beverly, Levi, Krishnamoorthy, Veena, Bhasin, Manoj, Capobianco, Anthony J., Kelliher, Michelle A.

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Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma von HANLON, Linda, AVILA, Jacqueline L, LONG, Fenella, CAPOBIANCO, Anthony J, KISSIL, Joseph L, DEMAREST, Renée M, TROUTMAN, Scott, ALLEN, Megan, RATTI, Francesca, RUSTGI, Anil K, STANGER, Ben Z, RADTKE, Fred, ADSAY, Volkan

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Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion von Shao, Hongwei, Kong, Ranran, Ferrari, Massimiliano L, Radtke, Freddy, Capobianco, Anthony J, Liu, Zhao-Jun

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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth von Yang, Fan, Rodriguez-Blanco, Jezabel, Long, Jun, Swiderska-Syn, Marzena, Wynn, Daniel T, Li, Bin, Shen, Chen, Nayak, Anmada, Ban, Yuguang, Sun, Xiaodian, Suter, Robert K, McCrea, Heather J, Capobianco, Anthony J, Ayad, Nagi G, Robbins, David J

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Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription von Jin, Ke, Zhou, Wen, Han, Xiaoqing, Wang, Zhiqiang, Li, Bin, Jeffries, Shawn, Tao, Wensi, Robbins, David J, Capobianco, Anthony J

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (k cat/K m) of CK1α von Shen, Chen, Li, Bin, Astudillo, Luisana, Deutscher, Murray P, Cobb, Melanie H, Capobianco, Anthony J, Lee, Ethan, Robbins, David J

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Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner von Winterbottom, Emily F, Moroishi, Yuka, Halchenko, Yuliya, Armstrong, David A, Beach, Paul J, Nguyen, Quang P, Capobianco, Anthony J, Ayad, Nagi G, Marsit, Carmen J, Li, Zhigang, Karagas, Margaret R, Robbins, David J

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Identification of a Family of Fatty-Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties von Long, Jun, Tokhunts, Robert, Old, William M., Houel, Stephane, Rodgriguez-Blanco, Jezabel, Singh, Samer, Schilling, Neal, Capobianco, Anthony J., Ahn, Natalie G., Robbins, David J.

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