Structure-Based Drug Discovery of N‑((R)‑3-(7-Methyl‑1H‑indazol-5-yl)-1-oxo-1-(((S)‑1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo... von Bucknell, Sarah J, Ator, Mark A, Brown, Alastair J. H, Brown, Jason, Cansfield, Andrew D, Cansfield, Julie E, Christopher, John A, Congreve, Miles, Cseke, Gabriella, Deflorian, Francesca, Jones, Christopher R, Mason, Jonathan S, O’Brien, M. Alistair, Ott, Gregory R, Pickworth, Mark, Southall, Stacey M

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Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode von Southall, Stacey M., Banerjee, Joydeep, Brown, Jason, Butkovic, Kristina, Cansfield, Andrew D., Cansfield, Julie E., Congreve, Miles S., Cseke, Gabriella, Deflorian, Francesca, Hunjadi, Martina Petrovic, Hutinec, Antun, Inturi, Trinadh Kumar, Rupcic, Renata, Saxty, Gordon, Watson, Stephen P.

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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein–Ligand Complexes von Cansfield, Andrew D, Ator, Mark A, Banerjee, Joydeep, Bestwick, Michael, Bortolato, Andrea, Brown, Giles A, Brown, Jason, Butkovic, Kristina, Cansfield, Julie E, Christopher, John A, Congreve, Miles, Cseke, Gabriella, Deflorian, Francesca, Dugan, Benjamin, Hunjadi, Martina Petrovic, Hutinec, Antun, Inturi, Trinadh Kumar, Landek, Goran, Mason, Jonathan, O’Brien, Alistair, Ott, Gregory R, Rupcic, Renata, Saxty, Gordon, Southall, Stacey M, Zadravec, Rahela, Watson, Stephen P

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CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model von Cansfield, Andrew D, Ladduwahetty, Tammy, Sunose, Mihiro, Ellard, Katie, Lynch, Rosemary, Newton, Anthea L, Lewis, Ann, Bennett, Gavin, Zinn, Nico, Thomson, Douglas W, Rüger, Anne J, Feutrill, John T, Rausch, Oliver, Watt, Alan P, Bergamini, Giovanna

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Triazolo[1,5- a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR von Richardson, Christine M., Williamson, Douglas S., Parratt, Martin J., Borgognoni, Jenifer, Cansfield, Andrew D., Dokurno, Pawel, Francis, Geraint L., Howes, Rob, Moore, Jonathan D., Murray, James B., Robertson, Alan, Surgenor, Allan E., Torrance, Christopher J.

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Structure-guided design of pyrazolo[1,5- a]pyrimidines as inhibitors of human cyclin-dependent kinase 2 von Williamson, Douglas S., Parratt, Martin J., Bower, Justin F., Moore, Jonathan D., Richardson, Christine M., Dokurno, Pawel, Cansfield, Andrew D., Francis, Geraint L., Hebdon, Richard J., Howes, Rob, Jackson, Philip S., Lockie, Andrea M., Murray, James B., Nunns, Claire L., Powles, Jenifer, Robertson, Alan, Surgenor, Allan E., Torrance, Christopher J.

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Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked von Scrace, Simon F., Kierstan, Peter, Borgognoni, Jenifer, Wang, Lan-Zhen, Denny, Sarah, Wayne, Joanne, Bentley, Carol, Cansfield, Andrew D., Jackson, Philip S., Lockie, Andrea M., Curtin, Nicola J., Newell, David R., Williamson, Douglas S., Moore, Jonathan D.

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A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors von Bell, Kathryn, Sunose, Mihiro, Ellard, Katie, Cansfield, Andrew, Taylor, Jess, Miller, Warren, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte

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Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain von Hobbs, Christopher J, Bit, Rino A, Cansfield, Andrew D, Harris, Bill, Hill, Christopher H, Hilyard, Katherine L, Kilford, Ian R, Kitas, Eric, Kroehn, Antonin, Lovell, Peter, Pole, David, Rugman, Paul, Sherborne, Brad S, Smith, Ian E D, Vesey, David R, Walmsley, D Lee, Whittaker, David, Williams, Glyn, Wilson, Fiona, Banner, David, Surgenor, Allan, Borkakoti, Neera

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SAR studies around a series of triazolopyridines as potent and selective PI3K[gamma] inhibitors von Bell, Kathryn, Sunose, Mihiro, Ellard, Katie, Cansfield, Andrew, Taylor, Jess, Miller, Warren, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte

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Structure-based design of peptidomimetic antagonists of p56lck SH2 domain von HOBBS, Christopher J, BIT, Rino A, POLE, David, RUGMAN, Paul, SHERBORNE, Brad S, SMITH, Ian E. D, VESEY, David R, WALMSLEY, D. Lee, WHITTAKER, David, WILLIAMS, Glyn, WILSON, Fiona, BANNER, David, CANSFIELD, Andrew D, SURGENOR, Allan, BORKAKOTI, Neera, HARRIS, Bill, HILL, Christopher H, HILYARD, Katherine L, KILFORD, Ian R, KITAS, Eric, KROEHN, Antonin, LOVELL, Peter

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A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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Erratum: Corrigendum: A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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Correction: Corrigendum: A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

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CGRP ANTAGONIST COMPOUNDS von Ott, Gregory R, O'Brien, Michael Alistair, Deflorian, Francesca, Cansfield, Julie, Brown, Giles Albert, Cansfield, Andrew David, Watson, Stephen Paul, Congreve, Miles Stuart, Swain, Nigel Alan

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CGRP ANTAGONIST COMPOUNDS von OTT, Gregory R, BROWN, Giles Albert, DEFLORIAN, Francesca, CONGREVE, Miles Stuart, CANSFIELD, Julie, O'BRIEN, Michael Alistair, WATSON, Stephen Paul, SWAIN, Nigel Alan, CANSFIELD, Andrew David

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CGRP ANTAGONIST COMPOUNDS von Ott, Gregory R, O'Brien, Michael Alistair, Bortolato, Andrea, Deflorian, Francesca, Cansfield, Julie, Brown, Giles Albert, Cansfield, Andrew David, Watson, Stephen Paul, Congreve, Miles Stuart, Swain, Nigel Alan, Christopher, John Andrew

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